THROMBOTIC DISORDERS

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Updated Clinical Practice Guidelines for Venous Thromboembolism: Pregnant and Pediatric Patients

In this 3-part series, Hematology Advisor spoke with experts about the revisions to the ASH clinical practice guidelines for venous thromboembolism.

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Upper Extremity Deep Vein Thrombosis May Be Linked to Post-Thrombotic Syndrome

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Researchers conducted a systematic literature review to characterize the complications experienced by patients with upper extremity deep vein thrombosis.

Eltrombopag May Improve Quality of Life for Patients With Immune Thrombocytopenia

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Changes in health-related quality of life in patients with persistent/chronic immune thrombocytopenia were evaluated using 4 different tools.

Anticoagulant Therapies in Patients With Iliofemoral Deep Vein Thrombosis

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No differences were observed in patency rates or incidence of post-thrombotic syndrome in patients treated with rivaroxaban or a vitamin K antagonist.

Rivaroxaban May Decrease Risk of Major Bleeding in Patients With Venous Thromboembolism

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Compared with warfarin, rivaroxaban was found to reduce the risk of overall, gastrointestinal, and intracranial bleeding.

Patients With Splanchnic Vein Thrombosis May Have Increased Risk of Bleeding and Arterial Cardiovascular Events

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Researchers analyzed 1915 patients with splanchnic vein thrombosis for risk of bleeding and arterial cardiovascular events.

Eliminating H Pylori Infection May Benefit Adults With Immune Thrombocytopenic Purpura

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The role of H Pylori in the development of immune thrombocytopenic purpura is still unclear.

Low Occurrence of Venous Thromboembolism With Weight-Adjusted Prophylaxis After Bariatric Surgery

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Researchers performed a retrospective review of 1279 patients treated with a standardized, weight-adjusted tinzaparin regimen.

Cryopreserved Platelets May Safely Reduce Bleeding in Patients With Thrombocytopenia

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Bleeding scores improved in over half of the patients receiving cryopreserved platelets.

Direct-Acting Oral Anticoagulants May Be Efficacious in Treating Cancer-Associated Venous Thrombosis

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Researchers evaluated 12 studies including 4720 patients for recurrent VTE risk and major bleeding.

Prophylactic Rituximab May Decrease Relapse in Immune Thrombotic Thrombocytopenic Purpura

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Prophylactic rituximab may decrease relapse in immune thrombotic thrombocytopenic purpura by maintaining detectable levels of ADAMTS13 activity.

Pregnancy-Onset Immune Thrombocytopenic Purpura May Be Prognostic of Neonatal Thrombocytopenia

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Patients with pregnancy-onset ITP were more likely to deliver babies with neonatal thrombocytopenia compared with patients diagnosed before pregnancy.

Baseline Thrombocytopenia Associated With Mortality Risk in VTE

Patients with VTE with moderate to severe thrombocytopenia at baseline were associated with increased risk for major bleeding events and all-cause mortality.

Baseline Thrombopoietin Levels May Help Predict Response to ITP Treatment

By Leah Lawrence

Results of the retrospective study require further confirmation.

Fostamatinib Appears Effective for Immune Thrombocytopenia

Researchers found that stable responses occurred in 18 percent of patients on fostamatinib, versus 2 percent on placebo.

Fostamatinib Seems Effective for Immune Thrombocytopenia

Forty-three percent of patients on fostamatinib and 14% on placebo achieved overall responses (defined as ≥1 platelet count ≥50,000/μL within the first 12 weeks on treatment).

VTE Increases Risk for Chronic Thromboembolic Pulmonary Hypertension

By Laurel Ranger

A number of risk factors were associated with chronic thromboembolic pulmonary hypertension, including, age >70 years, female gender, and pulmonary embolism at first venous thromboembolism.

Adding Rituximab to Prednisolone May Improve Long-Term Response in Immune Thrombocytopenia

By James Nam, PharmD

The efficacy of rituximab plus prednisolone had not been evaluated prior to the current study.

VTE Linked to Acute Decline in Physical Function in Women

Greater difference in physical decline for women specifically reporting pulmonary embolism.

Perioperative Red Blood Cell Transfusions Linked to Postoperative VTE

Perioperative red blood cell transfusion linked to increased adjusted odds of venous thromboembolism, deep vein thrombosis, and pulmonary embolism.

Oral Anticoagulant Effective in Recurrent VTE Prevention in Cancer Patients

By Da Hee Han, PharmD

At the end of 6 months, the rate of VTE recurrence was 4% among rivaroxaban patients vs 11% in the dalteparin arm (hazard ratio [HR] 0.43, 95% CI: 0.19 to 0.99).

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