A Novel and Rapid Assay for Sickle Cell Disease Screening
Children born with sickle cell disease in low-resource regions of the world often remain undiagnosed and therefore do not receive appropriate treatment.
Children born with sickle cell disease in low-resource regions of the world often remain undiagnosed and therefore do not receive appropriate treatment.
Complications in older patients with sickle cell disease are sometimes misattributed to their disease, possibly delaying appropriate diagnosis and treatment.
Approximately 1 in 500 African Americans in the United States has sickle cell disease.
Hydroxyurea, an antimetabolite, is thought to cause an immediate inhibition of DNA synthesis by acting as a ribonucleotide reductase inhibitor, without interfering with the synthesis of ribonucleic acid or of protein.
Using the infarct heat map, the investigators determined that infarct density was higher in the deep white matter and co-localized with the elevated OEF region in the independent prospective cohort.
Patients with sickle cell disease may have a unique cardiomyopathy with restrictive physiology.