GC027 Shows Promise as Therapy for Adult Relapsed, Refractory T-Cell ALL
All 5 patients had a complete response or complete response with incomplete hematologic recovery, and 4 of the 5 patients were minimal residual disease–negative.
Leukemia
Risk of Secondary AML May Be Increasing Among Patients With Refractory Anemia
Despite survival improvements in refractory anemia compared with other subtypes of MDS, patients may still have an increased risk for secondary AML.
Durable Long-Term Responses in B-cell Lymphoma and Chronic Lymphocytic Leukemia After Anti-CD19 CAR T-Cell Therapy
Researchers reported long-term follow up from the first clinical trial of anti-CD19 CAR T cells that revealed responses against lymphoma.
Novel Pediatric Disease Risk Index in Patients With ALL, AML for Allogeneic Hematopoietic Cell Transplantation
Researchers outlined a validated p-DRI for AML and ALL that successfully stratifies children undergoing allogeneic hematopoietic cell transplantation for prognostication.
Anti-CD117 CAR T Cells Promising Immunotherapeutic Modality for AML
Generating CAR T cells against human cognate receptor CD117 may be a successful treatment for patients with AML.
Phase 2 Study of CPX-351 Results Promising in Relapsed Pediatric AML
Encouraging response rates in children with first relapse AML treated with CPX-351 followed by FLAG provide rationale for de novo AML study.
ETV6 Sequencing Important Among Patients With Inherited Thrombocytopenia, Malignancy
It may be important to sequence ETV6in patients with inherited thrombocytopenia or malignancy and to schedule regular follow-ups to check for secondary cancers.
Preliminary Evidence Supports Benefit of Urinary-Derived hCG in Acute GVHD
In this phase I clinical trial, 2 different cohorts of patients with acute GVHD received subcutaneous injections of uhCG along with standard-of-care treatment.
Study Links DLBCL and CLL Incidence to Race and Ethnicity, Urban Status
The incidence of DLBCL among Hispanic individuals and CLL among non-Hispanic black individuals was associated with urban status.
Gene Expression Approach Using Residual Cells Feasible for Future CLL Studies
Two extraction and amplification methods for gene expression analyses on residual leukemic cells may improve future studies when working with fewer cells.
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