Sorafenib Maintenance Therapy After Allo-HSCT Improves Outcomes in FLT3-ITD–Positive AML
Among patients with FLT3-internal tandem repeats, sorafenib maintenance therapy reduces the risk of relapse and death after allo-HSCT.
Hematopoietic Stem Cell Transplantation
Allogeneic-HSCT Outcomes With Varied Donor Sources in Adult T-Cell Leukemia/Lymphoma
Researchers studied the pros and cons of transplantation from different donor sources to enhance overall outcomes of allo-HSCT in adults with T-cell malignancies.
Antithymocyte Globulin to Prevent Graft-vs-Host Disease Following Matched-Sibling Donor Transplantation
For patients receiving HLA-matched sibling donor transplantation, antithymocyte globulin can reduce the incidence of acute graft-vs-host-disease.
Comparison of Early and Late Transplant-Associated Thrombotic Microangiopathy
Although etiologies and traits of early and late thrombotic microangiopathy may vary, outcomes for both patient populations are similarly unfavorable.
Cognitive Impairment Affects Survival Outcomes in Geriatric Patients Undergoing Allogeneic HCT
An analysis of more than 300 patients with hematologic cancer found that cognitive impairment had a negative effect on outcomes, whereas age and IADLs did not.
Study Finds Vancomycin Increased Risk for Cytomegalovirus Reactivation After Hematopoietic Cell Transplant
A retrospective study of CMV-seropositive adults receiving allogeneic HCT and CMV-seronegative HLA-matched sibling donors found that vancomycin exposure before HCT increased the risk for CMV reactivation.
Benefit From CD19 CAR T-Cell Therapy in Relapsed/Refractory B-Cell ALL
Patients with B-cell ALL who are treated with CAR T-cell therapy and allo-HSCT may have better outcomes than those treated only with CAR T-cell therapy.
Ruxolitinib in Glucocorticoid-Refractory Acute Graft-vs-Host Disease After Allogeneic Stem Cell Transplantation
For patients with GVHD, ruxolitinib improves efficacy outcomes compared with 9 other commonly used options.
HLA-DPB1 Expression Level, Number of Mismatches Are Associated With Risk of GVHD After HCT
The HLA-DPB1 mismatch expression level and number of mismatches was associated with GVHD after unrelated donor HCT.
C difficile Infection May Increase Graft vs Host Disease Risk
Patients undergoing allogeneic stem cell transplantation who experience C difficile infections may have an increased risk for graft vs host disease.
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