Trial Evaluating Lisocabtagene Maraleucel for Relapsed/Refractory CLL Meets Endpoint
Lisocabtagene maraleucel is a CD19-directed genetically modified autologous T cell immunotherapy.
Diagnosis & Disease Information
Brukinsa Gains Approval for Chronic Lymphocytic Leukemia
The approval was based on data from the phase 3 SEQUOIA and ALPINE studies in patients with CLL/SLL.
Zanubrutinib Outperforms Ibrutinib in Relapsed/Refractory CLL/SLL
Zanubrutinib prolongs progression-free survival, when compared with ibrutinib, in patients with relapsed/refractory CLL/SLL, a phase 3 trial suggests.
Chronic Lymphocytic Leukemia Updates Presented at the 2022 ASH Annual Meeting
Research in patients with CLL showed that zanubrutinib can outperform ibrutinib, a triplet is effective for high-risk CLL, cell death may predict the depth of response, and a CAR T-cell therapy is likely not an option for CLL patients.
MRD-Guided Treatment Intensification Feasible in R/R Chronic Lymphocytic Leukemia
Researchers sought to determine whether uMRD could determine discontinuation of venetoclax or the addition of ibrutinib in patients with R/R CLL.
Addition of Anti-CD19 CAR-T to Ibrutinib Yields Deep, Durable Remissions in Chronic Lymphocytic Leukemia
Researchers sought to determine whether adding anti-CD19 CAR-T cells to ibrutinib would improve remission rates in CLL.
Zanubrutinib May Produce Better Outcomes Than Ibrutinib in Rel/Ref CLL, SLL
Zanubrutinib may produce superior outcomes to ibrutinib in patients with relapsed/refractory chronic lymphocytic leukemia or small lymphocytic lymphoma.
Current and Emerging BTK Inhibitors for Chronic Lymphocytic Leukemia
Researchers sought to determine the landscape of BTK inhibitors for treating patients with CLL.
Surface IgM Signaling Capacity Associated With Ibrutinib Resistance in Chronic Lymphocytic Leukemia
Researchers sought to determine whether IgM levels would impact treatment responsiveness to ibrutinib in patients with CLL.
Novel Therapies Present Opportunity to Improve Outcomes for Patients With Richter Transformation
Researchers sought to identify novel therapeutic approaches to patients who develop Richter transformation.
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