Zanubrutinib Appears Superior to Ibrutinib in Patients With Relapsed/Refractory CLL/SLL
Researchers sought to determine whether zanubrutinib would have superior clinical outcomes to ibrutinib in patients with CLL/SLL.
Chronic Lymphocytic Leukemia
Triplet Falls Short in Relapsed/Refractory Chronic Lymphocytic Leukemia
Combination acalabrutinib, obinutuzumab, and venetoclax did not meet the prespecified activity threshold in the CLL2-BAAG trial.
Long-Term Follow-Up Shows Continued Survival Benefit With Ibrutinib/Rituximab in Chronic Lymphocytic Leukemia
Researchers sought to determine whether there was a sustained benefit for patients with CLL receiving treatment with ibrutinib plus rituximab.
New Tablet Formulation of Calquence Approved for CLL, SLL, MCL
The approval was based on data from the phase 1 ELEVATE-PLUS trials, which showed the acalabrutinib 100mg tablets were bioequivalent to the acalabrutinib 100mg capsules.
PFS Not Associated With 1-Year Depth of Response to Ibrutinib in Chronic Lymphocytic Leukemia
Researchers sought to determine whether there was a difference in PFS based on depth of response with ibrutinib at 1 year in patients with CLL.
Zanubrutinib Bests Bendamustine-Rituximab in Previously Untreated CLL/SLL
Zanubrutinib can improve progression-free survival, when compared with bendamustine-rituximab, in previously untreated CLL/SLL, a phase 3 trial suggests.
Ferroptosis-Related Gene Expression May Predict Outcomes in Chronic Lymphocytic Leukemia
Researchers sought to determine whether there was an association between ferroptosis-related genes and prognosis for patients with CLL.
FDA Warns of Increased Side Effects, Death Risk With Duvelisib
Copiktra is an oral inhibitor of phosphoinositide 3-kinase.
Venetoclax Plus Obinutuzumab May Improve PFS, Not OS in Chronic Lymphocytic Leukemia
Patients with previously untreated CLL had superior PFS with fixed duration venetoclax plus obinutuzumab, with or without ibrutinib.
Bacterial Coinfection Associated With Poor COVID-19 Outcomes in Chronic Lymphocytic Leukemia
Researchers sought to determine the case fatality rate in patients with CLL who were infected with SARS-CoV-2.
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