CAR-T Cell Therapy Promising in Multiple Myeloma
Researchers sought to determine whether idecabtagene vicleucel, a CAR-T cell therapy, would be a viable treatment option in heavily pretreated patients with relapsed or refractory multiple myeloma.
CAR-T Therapy
CAR T Cell Therapy Shows Benefits in Patients With R/R Indolent Non-Hodgkin Lymphoma
The ZUMA-5 trial studied whether CAR T cell therapy with axi-cel had any clinical benefits in patients with indolent NHL.
Risk Factors for Early Relapse of DLBCL After CAR-T Therapy
Nearly half of all relapses occurred within the first month of CAR-T infusion.
Anti-CD19 CAR T-Cell Therapy Effective in Relapsed/Refractory B-Cell Acute Lymphocytic Leukemia
Investigators aimed to determine and compare outcomes in patients with relapsed or refractory ALL who were treated with anti-CD19 CAR T-cell therapy.
BCMA-Directed CAR T-Cell Therapy Gets Priority Review for Multiple Myeloma
The BLA is supported by data from the open-label, single-arm phase 2 KarMMa study.
Opposition to a European Patent for CAR-T Therapy: A Mechanism to Control High Drug Prices?
The nongovernmental organizations argued that patents for this CAR-T should never have been granted in the first place because the underlying technology is not novel.
Phase 1 Trial Featuring First shRNA-Edited CAR-T Therapy to Begin
FDA approves allogenic CAR T cells targeted at BCMA for phase 1 trial in relapsed/refractory multiple myeloma.
Characterization of Neurotoxicity After CAR-T in LBCL
Neurotoxicity is a common AE associated with CAR-T administration, but there are limited data characterizing it among patients with LBCL who received axi-cel.
Can Culturing CAR T Cells With Ibrutinib Improve Their Efficacy in CLL?
Sustained remission of CLL is associated with enrichment of a less-differentiated, early-memory phenotype of T cells in the apheresis product used to make CAR-T therapies.
G-CSF Appears Safe in CAR-T–Treated Patients With Refractory/Relapsed B-Cell Lymphoma
The treatment reduced hospital stay but not neutropenia duration or infection rate.
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