A prospective, single-center study aimed to determine the prevalence of DVT after TKA among patients with hemophilia A and found that contrast-enhanced CT led to better detection compared with ultrasound.
In about 10% of pregnancies in which the mother has a congenital bleeding disorder, recommended fetal precautionary measures may influence the mode of delivery.
Researchers assessed whether hemophilia A disease registry could be used instead of clinical studies to determine orphan drug safety in pediatric patients.
There was a median bleeding score of 21 among patients with Glanzmann thrombasthenia, 9 in Bernard-Soulier syndrome, 10 in dense granule deficiency, 7 in ADP pathway defect, 8 in TxA2 pathway defect, 6 in isolated thrombocytopenia, and 8 in complex abnormalities.
Genetic mutations associated with the heterogeneity of hemophilia B Leyden may also be linked to mechanisms that increase factor IX levels with age.
VTE-BLEED prognostic scores did not accurately identify patients with VTE who were at high risk of bleeding events.
New developments in lab assays have allowed for more specialized assessments of VWD activity, leading to better diagnoses and various treatment options.
The percentage of discordance in onsite and off-site laboratory testing of von Willebrand disease remains high.
Sustained improvement was noted after the administration of tocilizumab, an interleukin-6 antagonist.
The exact number of hemophilia cases are unknown and estimates of the size and characteristics of the US hemophilia population are needed for healthcare planning and resource needs assessment.
