Mantle Cell Lymphoma: Novel Scoring System May Aid in Determining Prognosis
Using data from 108 patients, researchers designed MIPI-P, a novel scoring system for determining MCL prognosis.
Using data from 108 patients, researchers designed MIPI-P, a novel scoring system for determining MCL prognosis.
Physicians noted that patients receiving best supportive care were more likely to be interested in low-intensity treatments if the risk for side effects was lower.
This phase 2 study used a crossover design in which study medication and placebo were administered to all patients in cycles A and B of chemotherapy, respectively.
No systematic investigations have evaluated the publication timing of oncology drug registration trial results relative to the approval of these drugs by the FDA.
Researchers aimed to determine whether the addition of radiotherapy was associated with a risk for adverse events among patients treated with ICIs.
All 5 patients had a complete response or complete response with incomplete hematologic recovery, and 4 of the 5 patients were minimal residual disease–negative.
Despite survival improvements in refractory anemia compared with other subtypes of MDS, patients may still have an increased risk for secondary AML.
Core limitations were defined as lack of randomization, lack of overall survival data, inappropriate use of crossover, and use of suboptimal control arms.
The data reinforce the need for direct comparison of CAR-T and autologous transplantation.
Zanubrutinib demonstrated statistically significant and clinically meaningful advantages in safety and tolerability in patients with WM compared with ibrutinib.