Recommendations for the management of iron deficiency anemia including oral and intravenous iron therapies.
Anemias
Hemoglobin Thresholds for Transfusion in Preterm Infants With Anemia
Study results suggest that a higher hemoglobin threshold may lead to more transfusions for preterm infants with anemia but without improving outcomes.
Durable Erythroid Response With Lenalidomide, Epoetin Alfa in Refractory Myelodysplastic Syndromes
A phase 3 trial suggests higher responses when epoetin alfa is added to lenalidomide in treatment of erythropoietin-refractory myelodysplastic syndromes.
Metabolic Irregularities of Tryptophan and Serotonin Linked to Morbidity in Fanconi Anemia
A new study explores disruption of tryptophan metabolism, manifesting as dysregulation of serotonin metabolism, in patients with Fanconi anemia.
Anti-Inflammatory Drug May Improve ESA Hyporesponsiveness in HD
In a short-term trial involving hemodialysis patients, ziltivekimab significantly improved erythropoietin resistance index.
FDA Requests Clarification of Data to Complete Roxadustat Review
The Agency announced that additional clarification of clinical data was needed prior to completing the review.
BCL11A Inhibition to Induce Fetal Hemoglobin Shows Promise in Sickle Cell Disease
Among patients with sickle cell disease, inhibition of BCL11A via gene knockdown is an effect target to induce fetal hemoglobin.
IV Iron Products: Adverse Events, Associated Costs Compared
The comparative study aimed to analyze AEs as well as estimate the associated medical costs for 4 IV iron preparations.
CRISPR-Cas9 Gene Editing May Be Effective in β-Thalassemia, Sickle Cell Disease
Preliminary results suggest that CRISPR-Cas9 editing of BCL11A may benefit patients with sickle cell disease and β-thalassemia by potentially eliminating vaso-occlusive episodes or the need for transfusion.
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