Graft, Survival Outcomes After Liver Transplant in Patients With Sickle Cell Disease
Investigators analyzed graft and survival outcomes among patients with SCD who received liver transplants.
Anemias
Molidustat Noninferior to Darbepoetin in Nondialysis CKD
In 2 Japanese trials of nondialysis patients, molidustat proved noninferior to darbepoetin alfa, an erythropoiesis-stimulating agent, in correcting and maintaining hemoglobin levels over 36 weeks.
UK Survey of COVID-19 With Hemoglobinopathies, Rare Anemias
According to a UK-based survery, a large number of people with hemoglobinopathies were infected with SARS-CoV-2 but COVID-19-related death was not linked.
How Do Sleep Disturbances in Sickle Cell Disease Affect Executive, Psychological Functioning?
For patients with SCD, anxiety significantly mediates the effect of sleep disturbances on executive functioning more than depression.
When Is Splenectomy Appropriate in Hereditary Hemolytic Anemia?
Investigators discuss surgical approaches and outcomes of total and partial splenectomy for the treatment of hereditary hemolytic anemia in children.
Baseline Patient-Reported Outcomes in Sickle Cell Disease
A report from the Sickle Cell Disease Implementation Consortium assessed patient-reported outcomes and clinical and psychosocial factors in SCD.
Ferriprox Twice-a-Day Tablet Dosing Approved for Transfusional Iron Overload Due to Thalassemia Syndromes
The FDA has approved a twice-a-day formulation of Ferriprox® (deferiprone; Chiesi) for the treatment of transfusional iron overload due to thalassemia syndromes when current chelation therapy is inadequate.
ASH 2020 Clinical Guidelines: Sickle Cell Disease and Cerebrovascular Disease
ASH published new clinical guidelines on the prevention, diagnosis, and treatment of CNS complications for children and adults with sickle cell disease.
Sutimlimab Under Review for Hemolysis in Cold Agglutinin Disease
The FDA has granted Priority Review for the Biologics License Application (BLA) for sutimlimab for the treatment of hemolysis in adult patients with cold agglutinin disease, a rare type of autoimmune hemolytic anemia.
Imatinib as Potential Tyrosine Kinase Inhibitor to Treat Sickle Cell Disease
Although SCD is often linked to microvasculature occlusion, some sequelae are caused by erythrocyte membrane weakening.
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