Survey Finds Variation in Practice Patterns for Neuroimaging in Sickle Cell Anemia
Survey finds variation in practice patterns for obtaining MRI/MRA for stroke prevention and monitoring in patients with sickle cell anemia.
Anemias
Gene-Corrected Hematopoietic Stem Cells Show Potential for Engraftment in Fanconi Anemia
Autologous transplantation with gene-corrected hematopoietic stem cells show engraftment and proliferation in nonconditioned patients with Fanconi anemia.
HIF-PHIs Show Short-Term Efficacy and Safety
A current meta-analysis of HIF-PHIs showed that these drugs improve the response rate of hemoglobin and decrease hepcidin levels.
Patients Undergoing Extracorporeal Photopheresis Should Be Monitored for Iron Deficiency Anemia
Patients receiving chronic extracorporeal photopheresis therapy are at risk of developing iron deficiency anemia.
Factors Contributing to Darbepoetin Responsiveness in CKD
In a Japanese study, approximately 1 in 8 CKD patients with anemia failed to respond to darbepoetin alfa therapy.
Vadadustat Noninferior to Darbepoetin in CKD
Despite favorable efficacy data, the HIF-PHI failed to demonstrate noninferiority to the ESA in patients with CKD with respect to the primary MACE safety endpoint.
Medical Marijuana Tied to Fewer Admissions in Sickle Cell Disease
But no change in opioid use observed for those receiving medical marijuana certification.
Erythroid Differentiation Regulation Via p53 Activation During Ribosome Biogenesis
Investigators characterized ribosome biogenesis dynamics during erythropoiesis to study the role of ribosome biogenesis in normal erythroid development.
Clonal Hematopoiesis in Hematologic Malignancies, Bone Marrow Failure Syndromes, and Stem Cell Clones
Recent studies have better elucidated the link between clonal hematopoiesis and hematologic malignancies.
Pyruvate Kinase Deficiency: Current and Prospective Treatment Options
As PKD directly affects the catalysis of substrates and products involved in the production of ATP, the glycolytic pathway is compromised, thus leading to several cellular defects.
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