GST Polymorphisms Are Associated With Risk of B-Cell Acute Lymphocytic Leukemia
Researchers sought to determine the impact of GST polymorphisms on the risk of B-ALL.
Diagnosis & Disease Information
F2-ISoP Levels in CSF a Potential Biomarker of Therapy-Related Cognitive Outcomes in Children With ALL
Researchers sought to determine if F2-ISoP levels could be a biomarker for cognitive dysfunction in children with ALL.
Registry Data Support Use of Ponatinib in CML, Ph+ ALL Resistant or Intolerant to Tyrosine Kinase Inhibitors
An analysis of a registry of patients with CML and Philadelphia chromosome-positive ALL demonstrated that ponatinib is efficacious in those with relapsed or refractory disease.
CAR T Cell Therapy May Not Improve Survival vs Chemotherapy in B-ALL After Allo-HSCT
Researchers sought to determine whether CAR T therapy would have a better result than pretransplant chemotherapy in patients with B-ALL undergoing allo-HSCT.
Phase 4 Feasibility Trial Is Evaluating At-Home Treatment of MRD-Positive BCP-ALL
Researchers are running a phase 4 feasibility trial to determine the safety and effectiveness of at-home blinatumomab treatment in patients with MRD-positive B cell precursor ALL.
High CMR Rates With Ponatinib Plus Blinatumomab in Adult Ph+ ALL
Although the standard of care for Ph+ ALL results in a 5-year overall survival of up to 50%, relapse is common and are frequently driven by the T3151 mutation in BCR-ABL.
Calorie Restriction May Increase Efficacy of Chemotherapy in Younger Patients With B-ALL
The IDEAL trial found that adolescents and young adults with B-cell acute lymphoblastic leukemia may benefit from restrictive diets and increased exercise.
Chimeric Antigen Receptor T-Cell Therapy Shows Positive Results in Pediatric Patients With B-Cell ALL
Researchers sought to determine the long-term safety and efficacy of KTE-X19 in pediatric and adolescent patients with relapsed or refractory B-cell acute lymphoblastic leukemia.
Blinatumomab Improved Survival for Patients With B-Cell ALL, but Not Significantly
Researchers sought to determine if immunotherapy including blinatumomab could improve disease-free survival for patients with B-cell ALL.
TBI Conditioning Before Stem Cell Transplantation Improves Survival in Pediatric ALL
Researchers sought to determine whether pediatric patients with ALL would have better OS if they received TBI prior to HSCT.
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