Short-Term 6-TG Exposure During Treatment for Pediatric ALL Associated With Hepatic SOS
Investigators analyzed the association between hepatic SOS and short-term application of 6-TG in 3983 pediatric ALL patients.
Acute Lymphoblastic Leukemia
Diet, Exercise Intervention Explored in Children With B-ALL
Reduction in fat gain not seen in overall cohort, but stratified analysis showed benefit among those overweight, obese at baseline.
High Cortactin, HS1 Levels Predict Worse Survival in Patients With B Cell Acute Lymphoblastic Leukemia
Researchers sought to determine whether high cortactin and HS1 expression may be linked with poorer prognosis for patients with B-ALL.
Genetic Mutations May Add to Racial Disparity in Child B-ALL
Increased incidence of IKZF1 deletion and IGH-CRLF2 translocation seen in Hispanic/Latino children with B-ALL.
Pyridoxine Plus Pyridostigmine Beneficial for Neurotoxicity in ALL
A team of investigators prospectively evaluated pediatric patients with ALL to determine the effectiveness of pyridoxine (vitamin B6) plus pyridostigmine therapy for vincristine-induced neurotoxicity.
Measurable Residual Disease Is Prognostic Factor Before Transplantation in First and Second Remission of Ph+ ALL
A team of investigators evaluated the effect of measurable residual disease at time of allogeneic hematopoietic cell transplantation in patients with ALL undergoing transplantation during either first or second complete remission.
Combination Sitagliptin, Tacrolimus, Sirolimus for Prophylaxis of Acute Graft-vs-Host-Disease
Investigators aimed to determine whether DPP-4 inhibition reduces the incidence of acute graft-vs-host disease among patients receiving allogeneic HSCT.
Total Body Irradiation vs Chemotherapy Conditioning for Pediatric Acute Lymphoblastic Leukemia
Investigators compared outcomes of chemotherapy conditioning with total body irradiation prior to hematopoietic stem cell transplantation in patients with acute lymphoblastic leukemia.
Pediatric-Inspired Regimen Promising in Adolescents, Young Adults With Acute Lymphoblastic Leukemia
A pediatric treatment-inspired approach may improve outcomes among adolescent and young adult patients with Philadelphia-negative acute lymphoblastic leukemia.
Survival Improving for Patients With Acute Lymphoblastic Leukemia Who Experience Relapse Following HSCT
Researchers identify factors that influence relapse after HSCT in patients with acute lymphoblastic leukemia.
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