ACCP Updates Guideline for Perioperative Management of Antithrombotic Therapy
New topics in the ACCP guideline include the perioperative management of patients receiving direct oral anticoagulants and P2Y12 inhibitor antiplatelet drugs.
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Lower Risk of Recurrent VTE With Direct Oral Anticoagulants vs Warfarin During Extended Anticoagulation
Researchers sought to determine whether direct oral anticoagulant or warfarin would be better for recurrent VTE in patients taking extended anticoagulation treatment.
Low Uptake of CHEST Guideline Seen on Surveillance Without Anticoagulation in Lower-Risk Acute Subsegmental PE
Researchers sought to determine the utilization of CHEST guidelines for administering anticoagulants for patients with subsegmental PE.
Silent Cerebral Infarction Common in Immune Thrombotic Thrombocytopenic Purpura Survivors
Researchers sought to determine the incidence of silent cerebral infarction in survivors of immune thrombotic thrombocytopenic purpura.
90-Day Home Times Following Endovascular Thrombectomy for Medium-Vessel Occlusion
A study was conducted to assess clinical outcomes via 90-day home time in patients with medium-vessel occlusion treated with endovascular thrombectomy.
Characteristics Identified for VTE in Young Adults, Older Adults, and Adolescents
Researchers sought to determine the different characteristics for acute VTE in young adults and older adults.
Direct Oral Anticoagulant Therapy Noninferior to LMWH in Preventing Recurrent VTE in Patients With Cancer
Researchers sought to determine whether direct oral anticoagulants would do as well in preventing VTE in patients with cancer as LMW heparin
Similar Rates of Bleeding, Thrombosis Seen for Long-Term Lower Dose of Apixaban in Patients With Cancer
Researchers sought to determine whether lowering apixaban from the standard 5.0 mg twice daily dose to 2.5 mg twice daily would impact bleeding and thrombosis rates for patients with cancer.
Recombinant ADAMTS13 Appears to Reduce TTP Events in Congenital Thrombotic Thrombocytopenic Purpura
Researchers sought to determine whether recombinant ADAMTS13 prophylaxis would be a viable therapy for patients with congenital thrombotic thrombocytopenic purpura.
LMWH May Not Reduce VTE Risk in Hospitalized Patients
Researchers sought to determine whether LMWH would lead to a reduction in the likelihood of developing a symptomatic confirmed VTE in hospitalized patients.
Recombinant ADAMTS13 Shows Clinical Promise in iTTP
Researchers sought to determine whether recombinant ADAMTS13 would have clinical benefit for patients with iTTP.
LMW Heparin Does Not Increase Live Births in Women With Inherited Thrombophilia and Recurrent Miscarriage
Researchers sought to determine whether LMW heparin would increase the rate of live births seen in women with inherited thrombophilia and recurrent miscarriage.
Resource Utilization and Outcomes With Acute, Low-Risk Pulmonary Embolism
Researchers sought to determine the resource utilization for patients with acute, low-risk pulmonary embolism.
Caplacizumab May Delay ADAMTS13 Normalization in iTTP
Researchers sought to determine ADAMTS13 activity in a cohort of patients with iTTP receiving caplacizumab.
Risk Factors for Venous Thromboembolism in Kidney Transplant Recipients Identified
Venous thromboembolism occurred in the graft in 15.4% of patients.
Pulmonary Embolism Symptoms Affected by Disease Severity, Sex, Age, BMI
Investigators sought to explore the relationships between clinical presentation of acute PE, patient characteristics, PE severity, and mortality.
Venous Thromboembolism Linked to Hospitalization for an Eating Disorder
Researchers sought to identify any links to venous thromboembolism in patients hospitalized for an eating disorder.
Low Failure Rate Seen With Pulmonary Embolism Rule-Out Criteria (PERC)
Researchers sought to determine the use of a pulmonary embolism rule-out criteria rule and its failure rate.
No Benefit Seen With Early Administration of 4-Factor Prothrombin Complex Concentrate in Patients With Trauma at Risk of Massive Transfusion
Researchers sought to determine whether early administration of 4F-PCC would reduce 24-hour blood product consumption in patients with trauma at risk of massive transfusion.
When Should VTE Prophylaxis Be Initiated in Patients With Thrombocytopenia?
Researchers quantified the risks of bleeding and VTE associated with early VTE prophylaxis in critically ill patients with thrombocytopenia in a range of platelet counts.
Spironolactone Does Not Increase Venous Thromboembolism Risk in Acne
Researchers evaluated whether patients with acne treated with spironolactone are at increased risk for venous thromboembolism.
Post-Traumatic Stress Disorder and Quality of Life Impairments in Adults With Thrombotic Microangiopathies
Researchers sought to determine the impacts iTTP or aHUS have on patients’ quality of life and mental health.
Risks Identified for Venous Thromboembolism in Acute Hematogenous Musculoskeletal Infections in Children
Researchers sought to determine risk factors for VTE in pediatric patients hospitalized with acute hematogenous musculoskeletal infections.
Patients With Immune‑Mediated Thrombocytopenic Thrombotic Purpura Show Microvascular Hyporeactivity
Researchers sought to assess patients with acute iTTP with marked endothelium-mediated microvascular hyporeactivity.
Prediction of Major Bleeding by Machine Learning Shows Promise in Patients Taking Anticoagulation for VTE
Researchers sought to develop a machine learning algorithm to predict the risk of bleeding among patients with venous thromboembolism.
Radical Cystectomy Increases Risks for Thromboembolic Events
Swedish studies reveal significantly elevated risks for myocardial infarction, ischemic stroke, pulmonary embolism, and deep vein thrombosis.
Supernumerary Sex Chromosome Aneuploidy May Impact Venous Thromboembolism Risk
Researchers sought to determine whether there is a link between presence of supernumerary sex chromosome aneuploidy and risk of VTE.
High Risk for Bleeding in Older Patients Anticoagulated for Venous Thromboembolism
Researchers sought to determine bleeding risks for older patients treated with anticoagulation with vitamin K antagonists for the treatment of VTE.
Open ADAMTS13 Appears to Have Diagnostic Value in Immune Thrombotic Thrombocytopenic Purpura
Researchers sought to determine whether ADAMTS13 with an open confirmation would impact diagnosis in patients with iTTP.
Blood Type May Predict Risk of Venous Thromboembolism Among Patients With Cancer
Researchers sought to determine whether ABO blood type may impact the risk of developing VTE in patients with cancer.
Relapse and Mortality Characteristics Identified for Adolescent Acquired Thrombotic Thrombocytopenic Purpura
Researchers sought to identify characteristics of adolescent compared with adult patients with acquired thrombotic thrombocytopenic purpura.
D-Dimer Testing Not Recommended for Determining Length of Required Treatment in Venous Thromboembolism
Researchers sought to determine whether using a D-dimer assay would help determine whether patients require extended treatment for VTE.
Novel Machine-Learning Model May Reduce Misdiagnosis in Heparin-Induced Thrombocytopenia
Researchers sought to develop implemented a machine-learning model for the diagnosis of heparin-induced thrombocytopenia.
Apixaban Compared With Dalteparin in Cancer-Related Venous Thromboembolism
Researchers sought to compare oral apixaban and subcutaneous dalteparin for treating patients with cancer-related venous thromboembolism.
Anticoagulation Therapy With Rivaroxaban Safe, Effective in Children With Cancer-Associated Venous Thromboembolism
Researchers sought to determine whether anticoagulation therapy using rivaroxaban would be effective in children with cancer-associated venous thromboembolism.
Genetics of Complement Dysfunction Identified in Immune Thrombotic Thrombocytopenic Purpura
Researchers sought to identify genes related to complement dysfunction in patients with iTTP.
Study of Mirasol®-Based Pathogen Reduction in Platelets Fails to Meet Primary Endpoint
Researchers sought to determine the efficacy of a Mirasol®-based pathogen-reduction strategy for platelets.
Risks of Intraventricular Hemorrhage and Death May Be Higher in Preterm Infants
Researchers sought to determine the risk of intraventricular hemorrhage and mortality in preterm infants with lower platelet counts.
High Incidence of Anticoagulation-Associated Abnormal Menstrual Bleeding in Women After Venous Thromboembolism
Researchers sought to determine whether there was a link between abnormal menstrual bleeding and treatment with anticoagulants for VTE.
Low-Quality Evidence Underlies Use of Intermittent Pneumatic Compression With Pharmacological Thromboprophylaxis for VTE
Researchers sought to determine whether the addition of IPC to thromboprophylaxis for prevention of VTE is based on sound evidence.
Vaccination Status Not Associated With Acute Thromboembolism Risk in COVID-19
Regardless of vaccination status, adults hospitalized for COVID-19 infection are at increased risk for acute thromboembolism
Pulmonary Embolism and Uterine Fibroid Rates Among Younger, Black Women
Researchers sought to examine characteristics of and outcomes for patients with venothromboembolism and concomitant fibroids or gynecologic cancers.
Most Patients With Cancer Unaware of Risk for Cancer-Associated Venous Thromboembolism
Researchers sought to determine whether patients with cancer were aware of their risk of developing cancer-associated venous thromboembolism.
Gab2 and MALT1 Influence Regulation of Thromboinflammation, Deep Vein Thrombosis
Researchers conducted an analysis of the Gab2-MALT1 pathway to determine whether it impacts the development of thromboinflammation and deep vein thrombosis.
Patterns Identified With Cerebral Venous Thrombosis in a Population-Based Study
Researchers sought to determine patters related to age and sex in outcomes for patients with CVT.
D-Dimer Levels Have Limited Value in Identifying Pulmonary Embolism in COVID-19
Researchers explored the use of D-dimer levels to rule out PTE in patients with COVID-19, as well as clinical associations between D-dimer levels and PTE.
Venous Thromboembolism Increasing in Inflammatory Bowel Disease Hospitalizations
Researchers assessed nationwide trends of venous thromboembolism-related hospitalizations among patients with inflammatory bowel disease.
Vaccination Status May Affect Venous Thromboembolism Risk in Ambulatory COVID-19
Researchers assessed the 30-day risk for VTE among ambulatory patients with COVID-19 and compared, via propensity-score matching, individuals without COVID-19 infection.
OAC in Patients With AF and COVID-19 Lowers Rates of Death, Thrombotic Events
Researchers assessed the relationship between oral anticoagulation for patients with COVID-19 and AF and incidence of in-hospital thrombotic events and death.
Variable Dose Thromboprophylaxis May Increase Survival in Patients With COVID-19
Researched compared standard vs variable thromboprophylaxis strategies on the risk of mortality among patients hospitalized with COVID-19.
Can Pulmonary Embolism Severity Indices Predict COVID-19-Related Adverse Events?
Can the pulmonary embolism severity index assess the risk for adverse events among patients hospitalized for COVID-19 who are not diagnosed with PE or VTE?
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