Thrombotic Disorders

Thromboprophylaxis Is Safe and Effective in Patients With High-Risk Cancer

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Intermediate anticoagulation doses appear to be safe and effective as thromboprophylaxis in patients with high thrombotic risk active cancer.

Effectiveness of Corticosteroids in the Treatment of Chemotherapy-Induced Thrombocytopenia

By

Lauren Dembeck, PhD

Researchers sought to determine whether corticosteroids would be an effective treatment for patients with chemotherapy-induced thrombocytopenia.

Patients With Cancer and COVID-19 Face Increased Risk of Thromboembolic Events

By

Jonathan Goodman, MPhil

Researchers sought to determine whether patients with cancer who had COVID-19 had an increased risk of experiencing thromboembolic events.

Prothrombic Immune Thrombocytopenia in Patients Following ChAdOx1 Vaccine

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Vicki Moore, PhD

Researchers sought to identify the experiences of patients who developed prothrombotic immune thrombocytopenia after receiving the ChAdOx1 vaccine (AZD1222) against SARS-CoV-2.

AHA Presidential Statement: The Link Between Opioid Use, CVD, and Stroke

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Inga Back, MPH

The AHA has issued a Presidential Advisory Statement outlining considerations for addressing the effects of opioids on cardiovascular and neurovascular health.

Features of Vaccine-Induced Thrombotic Syndrome Studied

No individual risk factors identified for VITT, but increased mortality seen for those with cerebral venous sinus thrombosis, low platelets.

Abelacimab Prevents VTE After Total Knee Arthroplasty

Single, postoperative IV dose of abelacimab superior to enoxaparin for preventing venous thromboembolism, with no increase in bleeding risk.

The flu vaccine for 2016-2017 was 48% effective overall

Prothrombotic Immune Thrombocytopenia Following COVID-19 Vaccination

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Lauren Dembeck, PhD

Researchers sought to describe the unexpected autoimmune prothrombotic disorder experienced after vaccination with the ChAdOx1 COVID-19 vaccine.

Andexanet alfa is the first anticoagulant reversal agent to receive global US FDA approval.

Racial/Ethnic Disparities Seen in Anticoagulant Initiation for A-Fib

Disparities seen among VA patients both for initiating any anticoagulant therapy and for initiating direct-acting oral anticoagulant use.

Thrombotic Events Linked With Higher Mortality Among Pediatric Patients Hospitalized With COVID-19, MIS-C

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Jonathan Goodman, MPhil

Researchers sought to determine the mortality rate for pediatric patients with COVID-19 or multisystem inflammatory syndrome in children who experience thrombotic events.

VTE Risk Up for Children With Inflammatory Bowel Disease

Venous thromboembolism occurred less often for those with Crohn disease versus ulcerative colitis

Guidelines for Management of Venous Thromboembolism in Latin America

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Vicki Moore, PhD

A panel convened to develop guidelines for management of venous thromboembolism in the Latin American region.

Ethnically Diverse Study Finds COVID-19 Increases Risk of Venous Thromboembolism

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Sheila Jacobs

Hospitalized patients with COVID-19 had a greater than 3-fold adjusted risk for venous thromboembolism compared with matched controls, the study found.

OAC Reduces Stroke Risk in AF or HFrEF Despite Greater Hemorrhage Risk

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Brandon May

In a meta-analysis, researchers sought to further clarify the role of oral anticoagulation for preventing ischemic stroke in patients with AF and HFrEF.

Direct and Indirect Platelet Activation Drives Thrombosis in Hyperhomocysteinemia

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Lauren Dembeck, PhD

Researchers sought to determine the mechanism through which hyperhomocysteinemia contributes to thrombosis, directly and indirectly activating platelets.

Disease Course, Risks Identified With Extrahepatic Portal Vein Thrombosis in Pediatric Patients

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Vicki Moore, PhD

Researchers sought to identify aspects of the disease course and risk factors involved with extrahepatic portal vein thrombosis (EHPVT) in pediatric patients.

Current clinical data can't confirm or deny the association between risk for VTE and testosterone.

Venous Thromboembolism and Lung Ultrasound Findings With COVID-19

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Vicki Moore, PhD

Researchers sought to determine the link between lung ultrasound findings and the development of VTE in patients with COVID-19.

Bullous Pemphigoid Linked to Preexisting Stroke, Malignancies

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Colby Stong

A novel study asks: Does a correlation exist between preexisting comorbidities and serum titers of anti-BP180 and 230 antibodies in patients with bullous pemphigoid (BP)?

Managing Systemic Autoimmune Diseases Associated With Thrombotic Microangiopathy

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Sheila Jacobs

Using data from the French National TMA registry, study authors evaluated the demographic and clinical characteristics of thrombotic microangiopathy in autoimmune diseases, and assessed therapeutic approaches.

Researchers compared the safety and effectiveness of apixaban and rivaroxaban in patients with VTE.

Venous Thromboembolism or Major Bleeding Seen Frequently in Patients With Glioblastoma

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Vicki Moore, PhD

Researchers sought to determine the rates of VTE and major bleeding in patients with glioblastoma.

Increased travel burden is associated with a decreased likelihood of receiving adjuvant chemotherapy

Association of COVID-19 With Venous Thromboembolism Events in Hospitalized Patients

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Lauren Dembeck, PhD

Researcher sought to determine the risk of developing VTE in patients with and without COVID-19 who were hospitalized.

CDKN2A Deletion Predicts Risk of Venous Thromboembolism in Patients With Glioblastoma

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Jonathan Goodman, MPhil

Researchers sought to determine whether CDKN2A deletion could predict a higher risk of VTE in patients with glioblastoma.

Researchers interviewed clinicians and patients to develop a conceptual model of congenital thrombotic thrombocytopenic purpura.

Analysis of the NEOCLOT Protocol for Patients With Catheter-Related Venous Thrombosis

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Vicki Moore, PhD

Researchers evaluated the NEOCLOT protocol for management of catheter-related venous thrombosis in neonates in the Netherlands.

More Clot Retrieval Attempts May Worsen Stroke Outcome

Number of clot retrieval attempts linked to infarct growth, which independently predicts unfavorable outcome in acute ischemic stroke.

Several novel treatment agents for myeloproliferative neoplasms are currently being studied in phase 1 or phase 2 trials.

Thromboses in Pediatric Patients With Myeloproliferative Neoplasms

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Vicki Moore, PhD

Researchers sought to determine the occurrence of thrombotic events in a cohort of pediatric patients with myeloproliferative neoplasms.

Intravenous Immune Globulin for Vaccine-Induced Thrombotic Thrombocytopenia

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Vicki Moore, PhD

Researchers described outcomes for 3 patients in Canada who were treated with high-dose IVIG for vaccine-induced immune thrombotic thrombocytopenia after receiving the ChAdOx1 nCoV-19 vaccine.

Anemia May Increase Risks of Ischemic Stroke and Poststroke Mortality

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Vicki Moore, PhD

Researchers sought to determine whether patients with anemia had an increased risk of ischemic stroke and poststroke mortality.

In a Canadian matched cohort study, intolerance drove patients with CP-CML to switch from generic im

Reduced Calf Muscle Pump Function Linked With Venous Thromboembolism Risk, Mortality

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Jonathan Goodman, MPhil

Researchers sought to determine whether patients with reduced calf muscle pump function may be at an increased risk for venous thromboembolism.

Women Are Under-Represented in Acute Stroke Trials

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Brandon May

This meta-analysis included patients with stroke and/or transient ischemic attacks to determine whether women are under-represented in clinical trials of acute stroke therapies.

Timely Endovascular Thrombectomy Imperative for Favorable Post-Stroke Outcomes

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Jessica Nye, PhD

A team of investigators evaluated the lifetime outcomes linked to the speed of endovascular thrombectomy success in patients with acute ischemic stroke.

Pradaxa Approved to Treat, Prevent VTE in Pediatric Patients

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Brian Park, PharmD

Pradaxa oral pellets are supplied in child-resistant packets in 20mg, 30mg, 40mg, 50mg, 110mg, and 150mg dosage strengths.

A central venous catheter insertion set.

Thrombotic Events Seen Frequently in Patients With Cancer and a Central Venous Catheter

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Vicki Moore, PhD

Researchers sought to determine the risk of thrombotic complications in patients with cancer who have a newly inserted central venous catheter.

Tinzaparin may effectively prevent VTE and major bleeding.

Novel Assay Using Platelet-Rich Plasma May Detect Hematologic Abnormalities Post-Surgery

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Jonathan Goodman, MPhil

Researchers sought to determine whether a novel CWA-small amount tissue factor-induced clotting factor IX assay could detect hemostatic abnormalities after surgery.

Preeclampsia May Be a Risk Factor for Later-Life Stroke

By

Rita Aghjayan

A team of investigators conducted a population-based cohort study to determine whether preeclampsia history affected the relative risk for incident stroke.

Researchers sought to determine methods for diagnosing and managing patients who develop coagulation disorders due to COVID-19 infection.

Diagnosis and Management of Coagulation Disorders Related to COVID-19

By

Caleb Rans, PharmD

Researchers sought to determine methods for diagnosing and managing patients who develop coagulation disorders due to COVID-19 infection.

Anticoagulation Ineffective for Patients With Isolated Distal Deep Vein Thrombosis

By

Patricia Chaney

Researchers sought to determine whether anticoagulation would be effective at preventing PE for patients with id-DVT.

Resection May Be Best Option in Patient Subset With Hepatocellular Carcinoma and PVTT

By

Jonathan Goodman, MPhil

Researchers sought to determine whether patients with HCC who develop PVTT would benefit from alternative treatments to systemic therapy.

Fostamatinib Shows Long-Term Safety and Efficacy in Immune Thrombocytopenia, Rheumatoid Arthritis

By

Ariela Katz

Researchers sought to determine the long-term safety and efficacy of fostamatinib for treating patients with immune thrombocytopenia and rheumatoid arthritis.

Hematology Advisor spoke with experts about the new ASH clinical practice guidelines for VTE.

Risk Factors for Venous Thromboembolism in Adolescent Girls Receiving Hormonal Therapy

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Vicki Moore, PhD

Researchers sought to identify and analyze risk factors for thrombosis in adolescent girls receiving hormonal therapy.

A geriatric doctor speaks to an elderly patient.

Thromboprophylaxis Reduces Thrombosis in Patients With POTS

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Patricia Chaney

Researchers sought to determine whether thromboprophylaxis may help treat patients with POTS to reduce CVC-related thrombosis.

Direct Oral Anticoagulant Therapy Shows Positive Impact on VTE in Pediatric Patients With Cancer

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Vicki Moore, PhD

Researchers sought to determine if there would be similar results for bleeding rates in pediatric patients with cancer and VTE who received either DOACs or LMWH.

Current State of Treatments for Cancer-Associated Venous Thromboembolism

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Vicki Moore, PhD

Wei Xiong, MD, PhD, sought to outline and clarify the current state of managing venous thromboembolism in patients with cancer.

Thromboembolism Risk May Be Linked With Immune Checkpoint Inhibitor Therapy

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Vicki Moore, PhD

Immune checkpoint inhibitor therapy may be linked to increased risk of thromboembolic events, particularly venous thromboembolism, in patients with cancer.

Direct-acting oral anticoagulants may be efficacious in treating cancer-associated VTE.

No Difference in Venous Thromboembolism Based on Venous Injury Treatment With Repair or Ligation

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Patricia Chaney

Researchers sought to determine whether there was a difference between venous repairs or ligation in rates of DVT or PE in patients with lower extremity venous injury.

Increased Risk for PSD in Elderly Women Following Ischemic Stroke

By

Melissa I. Alvarez

At the 2021 International Stroke Conference, researchers presented their findings on the differences in poststroke depression between elderly men and women.

Mechanical Thrombectomy: A Viable Option for Managing Posterior Circulation DMVOs

By

Brandon May

Researchers investigated the clinical and safety outcomes of mechanical thrombectomy for isolated posterior circulation DMVO stroke and compared them with standard medical treatment.