Better Guidelines for Diagnosing Pulmonary Embolism During Pregnancy Needed
Current guidelines to diagnosis pulmonary embolism in pregnant patients offer conflicting recommendations.
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Managing Neonatal Thrombocytopenia of Alloimmune Origin
A French working group developed a treatment algorithm for diagnosis and treatment of neonatal thrombocytopenia of suspected or confirmed alloimmune origin.
Apixaban May Reduce Risk for Venous Thromboembolism in Patients With Cancer
Significantly fewer patients receiving apixaban experienced thromboembolism and major bleeding compared with patients receiving placebo.
No Association Found Between Locations of Venous Thromboembolism and Occult Cancer
An analysis of 2300 patients found similar prevalence of abdominal, pelvic, and thoracic cancer in patients with deep vein thrombosis and pulmonary embolism.
Lack of Thromboprophylactic Benefit With Rivaroxaban in Ambulatory Patients With Cancer
Patients receiving rivaroxaban did not experience a statistically significant decrease in thrombotic events compared with patients receiving placebo.
Novel Risk Factors for Venous Thromboembolism in Pregnancy and Postpartum
Researchers assessed potential risk factors for venous thromboembolism during pregnancy and postpartum in more than 100,000 Japanese women.
Antithrombin Deficiency May Be Undertreated With Standard Heparin Therapy
Antifactor Xa activity after heparin spiking was lower in plasma samples from antithrombin-deficient patients compared with control samples.
Cablivi Approved for Acquired Thrombotic Thrombocytopenic Purpura
First FDA-approved therapy specifically indicated for the treatment of aTTP
A Serological Tool to Phenotypically Characterize Primary Antiphospholipid Syndrome
Researchers assessed the prevalence of various antiphosphatidylserine/prothrombin antibodies in patients with primary antiphospholipid syndrome.
Lower Platelet Transfusion Threshold in Neonates With Thrombocytopenia May Reduce Mortality
Researchers attempted to identify the appropriate platelet count transfusion threshold in preterm infants with severe thrombocytopenia.
Researchers Review Coagulation Risk Factors in Neonates and Children
The interactions between von Willebrand factors and its cleaving protease ADAMTS-13 recently emerged as risk factors for pediatric thromboembolism.
Statin Therapy May Reduce Thrombin Generation Potential in Patients With Thromboembolism
Statins may provide a therapeutic alternative to anticoagulant prophylaxis for venous thromboembolism.
Caplacizumab Cuts Time to Platelet Count Normalization in aTTP Patients
The HERCULES (NCT02553317) study included 145 patients with aTTP who were randomized to receive either caplacizumab 10mg or placebo in conjunction with plasma exchange and immunosuppression.
Upper Extremity Deep Vein Thrombosis May Be Linked to Post-Thrombotic Syndrome
Researchers conducted a systematic literature review to characterize the complications experienced by patients with upper extremity deep vein thrombosis.
Eltrombopag May Improve Quality of Life for Patients With Immune Thrombocytopenia
Changes in health-related quality of life in patients with persistent/chronic immune thrombocytopenia were evaluated using 4 different tools.
Anticoagulant Therapies in Patients With Iliofemoral Deep Vein Thrombosis
No differences were observed in patency rates or incidence of post-thrombotic syndrome in patients treated with rivaroxaban or a vitamin K antagonist.
Rivaroxaban May Decrease Risk of Major Bleeding in Patients With Venous Thromboembolism
Compared with warfarin, rivaroxaban was found to reduce the risk of overall, gastrointestinal, and intracranial bleeding.
Risk Factors Affecting Venous Thromboembolism in Older White and Black Women With Breast Cancer
Women with breast cancer were found to experience increased risk of developing VTE.
Patients With Splanchnic Vein Thrombosis May Have Increased Risk of Bleeding and Arterial Cardiovascular Events
Researchers analyzed 1915 patients with splanchnic vein thrombosis for risk of bleeding and arterial cardiovascular events.
Long-Term Outcomes After Approval of Anagrelide for Essential Thrombocythemia
A retrospective review uncovered significantly decreased OS and MFFS in patients with essential thrombocythemia after the approval of anagrelide.
Eliminating H Pylori Infection May Benefit Adults With Immune Thrombocytopenic Purpura
The role of H Pylori in the development of immune thrombocytopenic purpura is still unclear.
Low Occurrence of Venous Thromboembolism With Weight-Adjusted Prophylaxis After Bariatric Surgery
Researchers performed a retrospective review of 1279 patients treated with a standardized, weight-adjusted tinzaparin regimen.
Cryopreserved Platelets May Safely Reduce Bleeding in Patients With Thrombocytopenia
Bleeding scores improved in over half of the patients receiving cryopreserved platelets.
Direct-Acting Oral Anticoagulants May Be Efficacious in Treating Cancer-Associated Venous Thrombosis
Researchers evaluated 12 studies including 4720 patients for recurrent VTE risk and major bleeding.
Prophylactic Rituximab May Decrease Relapse in Immune Thrombotic Thrombocytopenic Purpura
Prophylactic rituximab may decrease relapse in immune thrombotic thrombocytopenic purpura by maintaining detectable levels of ADAMTS13 activity.
Pregnancy-Onset Immune Thrombocytopenic Purpura May Be Prognostic of Neonatal Thrombocytopenia
Patients with pregnancy-onset ITP were more likely to deliver babies with neonatal thrombocytopenia compared with patients diagnosed before pregnancy.
Baseline Thrombocytopenia Associated With Mortality Risk in VTE
Patients with VTE with moderate to severe thrombocytopenia at baseline were associated with increased risk for major bleeding events and all-cause mortality.
Baseline Thrombopoietin Levels May Help Predict Response to ITP Treatment
Results of the retrospective study require further confirmation.
Behcet Disease Should Be Considered a Causative Factor of Cerebral Venous Sinus Thrombosis
Behçet disease should be considered an initial causative factor of cerebral venous sinus thrombosis.
Outcomes of SLE-Associated Thrombotic Microangiopathy With Acquired ADAMTS13 Deficiency
Researchers investigated the characteristics and outcomes of patients with systemic lupus erythematosus-associated thrombotic microangiopathy based on their ADAMTS13 inhibitor profiles.
Promising Antibody Markers Identified for aPL-Related Pregnancy Complications
The aPS/PT antibodies might represent markers of aPL-related pregnancy complications, such as intrauterine grown restriction and preeclampsia.
VTE Increases Risk for Chronic Thromboembolic Pulmonary Hypertension
A number of risk factors were associated with chronic thromboembolic pulmonary hypertension, including, age >70 years, female gender, and pulmonary embolism at first venous thromboembolism.
Adding Rituximab to Prednisolone May Improve Long-Term Response in Immune Thrombocytopenia
The efficacy of rituximab plus prednisolone had not been evaluated prior to the current study.
Determining Elevated Thrombotic Risk in Systemic Lupus Erythematosus
Recent data from EULAR 2018 highlight the existence of thrombotic factors in systemic lupus erythematosus.
Oral Anticoagulant Effective in Recurrent VTE Prevention in Cancer Patients
At the end of 6 months, the rate of VTE recurrence was 4% among rivaroxaban patients vs 11% in the dalteparin arm (hazard ratio [HR] 0.43, 95% CI: 0.19 to 0.99).
Veno-Arterial Extracorporeal Membrane Oxygenation Improves Survival in Pulmonary Embolism
A protocolized study including initiation of VA-ECMO may reduce mortality in patients with massive PE.
Independent Predictors of VTE Identified in Systemic Sclerosis
Researchers evaluated the prevalence, risk factors, and effect of venous thromboembolism on survival in systemic sclerosis.
YEARS Criteria in Pulmonary Embolism Evaluation May Reduce Need for Imaging
D-dimer test adjustment based on pretest probability results may be a safe option to reduce the need for imaging during evaluation for pulmonary embolism.
Copeptin May Serve as Prognostic Biomarker for Pulmonary Embolism
Copeptin may be useful for identifying normotensive patients with pulmonary embolism who have a higher risk for an adverse outcome.
Deep Venous Thrombosis Ultrasound Protocol Recommendations
The Society of Radiologists in Ultrasound has endorsed recommendations regarding ultrasound imaging test protocols for patients with suspected deep venous thrombosis.
FDA Approves Fostamatinib for ITP After Insufficient Response to Previous Treatment
The US FDA granted approval to fostamatinib (Tavalisse), a kinase inhibitor, for the treatment of thrombocytopenia in patients with chronic IPT who have had an insufficient response to a previous treatment.
Pulmonary Embolism With Low Mortality Risk May Be Managed in Outpatient Setting
Observation in the emergency department followed by outpatient management with anticoagulation may be appropriate treatment for some patients with low-risk pulmonary embolism.
Safety and Validity of Pulmonary Embolism Rule-Out Criteria Evaluated
In patients at very low risk for pulmonary embolism, the pulmonary embolism rule-out criteria was noninferior to the conventional strategy of identifying thromboembolic events.
Raynaud Phenomenon, Migraine Linked to aPS/PT Antibodies in Primary Antiphospholipid Syndrome
In patients with primary antiphospholipid syndrome, the presence of phosphatidylserine/prothrombin complex antibodies is associated with Raynaud phenomenon and migraine.
Pulmonary Embolism Risk Prediction in Postpartum Women
Certain risk scores may not be reliable for predicting the presence of a pulmonary embolism in pregnant or postpartum women.
ITP Treatment Outcomes Not Improved With Intravenous vs Oral Corticosteroids
In this prospective study, researchers sought to compare the effectiveness of IV methylprednisolone vs oral prednisone in hospitalized patients with newly diagnosed ITP.
ITP Associated With Increased Risk of Cardiovascular Disease
Previous studies showed that there may be an association between ITP and CVD — especially among those who undergo splenectomy — but evidence is conflicting.
New Trial to Assess Dabigatran in Intermediate-Risk Pulmonary Embolism
A clinical trial is underway to assess the safety and efficacy of dabigatran in intermediate-risk pulmonary embolism after completing 72 hours of heparin therapy.
Thromboembolic Event Risk With Cisplatin vs Carboplatin in Lung Cancer
Platinum-based chemotherapy agents for lung cancer may increase the risk for thromboembolism.
High-Dose Dexamethasone Effective With Less Adverse Effects in ITP vs Corticosteroids
In this randomized trial, investigators sought to determine the effectiveness of high-dose dexamethasone vs conventional prednisone therapy in treatment-naïve patients with ITP. Results were presented at ASH 2017.
Oral Edoxaban Non-inferior to Dalteparin for Cancer-associated Venous Thromboembolism
Nearly 13% of patients in the edoxaban had first recurrent VTE or other major bleeding events during the 12-month follow-up compared with 13.5% of patients in the dalteparin arm.
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