ACCP Updates Guideline for Perioperative Management of Antithrombotic Therapy
New topics in the ACCP guideline include the perioperative management of patients receiving direct oral anticoagulants and P2Y12 inhibitor antiplatelet drugs.
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Incidence and Predictors of Thrombotic Events in Secondary Myelofibrosis
Researchers sought to characterize the incidence and risk factors for thrombotic events in patients with secondary myelofibrosis.
Heparin in Adult Patients with COVID-19 and Hypercoagulation Complications
Investigators sought to assess the effectiveness of heparin in patients hospitalized with COVID-19 and hypercoagulation.
Pregnant Patients With HIV May Be at Risk of Impaired Fibrinolysis
Researchers sought to determine whether patients with virologically suppressed HIV were more likely to have impaired markers of fibrinolysis.
Neutrophil-to-Lymphocyte Ratio May Predict Thrombotic Events in Polycythemia Vera
Researchers sought to determine whether neutrophil-to-lymphocyte ratio would be predictive of thrombotic events in patients with polycythemia vera.
Enoxaparin’s Effect on VTE and Major Bleeding After Bariatric Procedure
Investigators sought to determine the safety and efficacy of varying doses of enoxaparin regimens in patients receiving a bariatric procedure.
Risk of Arterial Thrombosis Higher With COVID-19 in Patients With Myeloproliferative Neoplasms
Researchers sought to determine whether there was a higher risk of developing thrombosis in patients with MPNs and COVID-19.
Tavneos Approved for ANCA-Associated Vasculitis
The approval was based on data from the phase 3 ADVOCATE trial, which evaluated Tavneos in 330 adults with newly diagnosed or relapsed ANCA-associated vasculitis.
Neuropsychiatric Symptoms and Stroke in Patients With Hereditary Thrombotic Thrombocytopenic Purpura
Researchers sought to determine rates of stroke, stroke-related disability, and presence of neuropsychiatric symptoms in patients with hTTP.
Coagulation Parameters Similar With Dabigatran Treatment in Adults and Children
Researchers sought to determine the patterns of coagulation times with concentration of dabigatran in adults and children with VTE.
Race, Income, and Rurality Tied to Certified Stroke Centers in the US
In an observational study, researchers examined certified stroke center care access between historically underserved and general communities.
Second-Line Azathioprine Potential Option for Immune Thrombotic Thrombocytopenic Purpura
Researchers sought to determine whether azathioprine should be evaluated as an option for second-line therapy in patients with of immune-related TTP.
Should Alteplase Be Used With Endovascular Thrombectomy for Ischemic Stroke?
Researchers sought to determine whether prespecified outcomes were different in endovascular thrombectomy with alteplase compared with EVT alone in patients hospitalized with acute ischemic stroke.
Flow Cytometry-Based Method of Diagnosis Developed for Vaccine-Induced Immune Thrombotic Thrombocytopenia
Researchers sought to determine whether an assay using flow cytometry may help to diagnose patients who have vaccine-induced immune thrombotic thrombocytopenia.
Enoxaparin Prophylaxis Not Effective in At-Risk Outpatients With COVID-19
Researchers sought to determine whether prophylaxis with enoxaparin would be effective in outpatients with COVID-19.
OVID Findings Do Not Support Routine Use of Anticoagulant in Outpatients With COVID-19
Researchers sought to determine whether thromboprophylaxis with enoxaparin would reduce early hospitalizations and deaths among outpatients with symptomatic COVID-19.
Link Found Between Anti-Endothelial Cell Antibodies and Thrombosis With Polycythemia Vera
Researchers sought to determine whether there was a link between anti-endothelial cell antibodies and thrombosis in patients with polycythemia vera.
No Recurrence of VTE 1 Year after COVID-19-Associated VTE Event
A study was conducted to determine outcomes in hospitalized patients with COVID-19 and VTE, during anticoagulation therapy and at 1-year follow-up.
Avatrombopag Plus MSCs Improved Platelet Recovery After Allo-HSCT
Researchers sought to determine whether avatrombopag with MSCs would improve platelet recovery in patients with prolonged thrombocytopenia after allo-HSCT.
Study Finds Racial Disparities in Cancer-Associated Thrombosis
Researchers sought to determine whether the incidence of CAT was different across designated racial groups.
Deep Vein Thrombosis, Pulmonary Embolism, and Bleeding Risk in COVID-19
Researchers sought to determine the risk for pulmonary embolism, deep vein thrombosis, and bleeding in patients recovering from COVID-19 infection.
Are Amyloid Fibrin Microclots Central to Long COVID?
Researchers sought to determine the factors that contribute to patients developing clots from Long COVID.
Migraine and Posterior Circulation Ischemic Stroke: Is There a Genetic Overlap?
Researchers sought to assess whether patients with migraine had a greater risk for PCiS than ACiS and if patients genetically predisposed to migraine showed an increased risk for PCiS or ACiS.
Khorana Score Unable to Stratify Patients With Certain Cancer Subtypes by Risk of Venous Thromboembolism
Researchers sought to determine whether the Khorana score would be able to risk-stratify patients according to the 6-month risk of incident VTE.
Fondaparinux Appears More Cost Effective Than Argatroban in Suspected Heparin-Induced Thrombocytopenia
Researchers sought to determine whether fondaparinux would be a more cost-effective treatment compared with argatroban in patients with suspected HIT.
Anticoagulation in Non-ICU Patients With COVID-19 at High Thrombosis Risk
What is the best current strategy for addressing patients with COVID-19 who are at high risk for thrombosis but are not in the ICU?
Thromboembolic Events Among Patients Hospitalized With COVID-19 Pneumonia
Researchers assessed outcomes and risk factors associated with thromboembolic events among patients with COVID-19 pneumonia.
Survivors of Medulloblastoma Have Greater Risk of Stroke, Severe Hearing Loss
Medulloblastoma survivors had an increased risk of long-term adverse outcomes.
Momelotinib Demonstrates Superiority Over Danazol in Thrombocytopenic Myelofibrosis
Researchers sought to compare the efficacy of momelotinib with danazol in patients with thrombocytopenic myelofibrosis who were symptomatic and anemic.
Antimicrobial Peptide LL‑37 Contributes to Thrombotic Complications in Patients With COVID‑19
Researchers sought to determine the role of LL-37 in patients with SARS-CoV-2 infection and whether it contributes to hypercoagulation.
Catheter-Directed Thrombolysis Appears Safe and Effective for Postpartum Deep Venous Thrombosis
Researchers sought to determine whether catheter-directed thrombolysis would be effective in patients with postpartum iliofemoral deep venous thrombosis.
Addressing Psychological Distress After Venous Thromboembolism
Researchers are seeking to address the psychological impact of patients who have survived VTE.
Rilzabrutinib Shows Promise in Immune Thrombocytopenia
Researchers sought to determine whether rilzabrutinib would be effective in treating immune thrombocytopenia.
Efgartigimod Looks Promising for Primary Immune Thrombocytopenia
The phase 3 ADVANCE trial evaluated the efficacy and safety of efgartigimod in 131 adults with primary ITP.
Racial Disparities Still Exist in Advanced Stroke Care, In-Hospital Mortality
Researchers sought to assess any recent changes in racial inequities trends in stroke treatment and in-hospital mortality, and whether racial inequities differed among patients living in rural areas.
Thromboprophylaxis Reduces Risk of VTE for Patients With Sickle Cell Disease and a Central Venous Access Device
Researchers sought to determine whether thromboprophylaxis would reduce venous thromboembolism risk in patients with SCD and a central venous access device.
Apixaban Compared With Warfarin for Thrombotic Antiphospholipid Syndrome
Researchers sought to determine whether patients with thrombotic antiphospholipid syndrome may be at greater risk of stroke when treated with apixaban instead of warfarin.
Adding Prednisone to Sirolimus May Improve Outcomes in KHE With KMP
Researchers sought to determine whether adding prednisone to sirolimus would improve outcomes in patients with Kasabach-Merritt phenomenon of kaposiform hemangioendothelioma.
OSA and Cognitive Impairment in Minor Ischemic Stroke
Is there a relationship between OSA and cognitive impairment in patients with minor ischemic stroke?
Recurrent Stroke Rate Among Young Adults With Embolic Stroke of Undetermined Source
In a prospective, longitudinal study, researchers determined the rates and factors associated with recurrent ischemic stroke, death, and new-onset atrial fibrillation among young adults.
Groups Issue Scientific Statement on Acute Stroke Care for Disability or Dementia
The AHA and the ASA released a joint scientific statement on the use of endovascular therapy or thrombolysis in adult patients with preexisting dementia or disability.
Venous Thromboembolism in IBD Not Linked to Increased Thrombophilia
Researchers investigated whether thrombophilia in patients with IBD significantly contributes to developing venous thromboembolic events.
Risk Factors for Thrombosis in Neonates in the Neonatal Intensive Care Unit
Researchers sought to determine the risk factors for both venous and arterial thrombosis in neonates admitted to neonatal intensive care units.
Risk for Blood Clots After COVID-19 Vaccination Explored
Two studies show increase in intracranial venous thrombosis, thrombocytopenia for those younger than 70 years and in CVST after ChAdOx1-S
Early Recognition Important for Implementing Interventions in Patients With Hereditary Thrombotic Thrombocytopenic Purpura
Researchers sought to determine the state of detection and initiation of prophylactic treatment for patients with hTTP.
Predicting Recurrent Venous Thromboembolism After Discontinuing Anticoagulants
A recent study sought to refine international risk classification guidelines on preventing VTE after discontinuation of anticoagulation therapy.
Thrombolysis vs Surgery for Treatment of Obstructive Prosthetic Valve Thrombosis
Investigators compared outcomes of thrombolytic therapy and surgery as first-line treatment for patients with obstructive prosthetic valve thrombosis.
Cost-Effectiveness of Eltrombopag for Patients With Immune Thrombocytopenia
Researchers sought to determine the cost-effectiveness of eltrombopag for patients with immune thrombocytopenia compared with intravenous immunoglobulin.
Fibrin Clot Structure and Dysregulated Fibrinolysis May Underlie Thrombosis Risk in Severe COVID-19
Researchers sought to determine the underlying reasons for thrombosis risk in patients with severe COVID-19.
BMI a Factor in Risk of Thromboembolic Events With Peripherally Inserted Central Catheters
A study sought to determine whether overweight/obesity is a factor in the development of thrombosis in cancer patients with peripherally inserted central catheters.
Interferon-Alpha and Hydroxyurea Show Efficacy in Polycythemia Vera and Essential Thrombocythemia
Researchers sought to determine whether interferon-alpha or hydroxyurea would be effective treatments for patients with essential thrombocythemia and polycythemia vera.
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