ACCP Updates Guideline for Perioperative Management of Antithrombotic Therapy
New topics in the ACCP guideline include the perioperative management of patients receiving direct oral anticoagulants and P2Y12 inhibitor antiplatelet drugs.
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Study of Mirasol®-Based Pathogen Reduction in Platelets Fails to Meet Primary Endpoint
Researchers sought to determine the efficacy of a Mirasol®-based pathogen-reduction strategy for platelets.
Risks of Intraventricular Hemorrhage and Death May Be Higher in Preterm Infants
Researchers sought to determine the risk of intraventricular hemorrhage and mortality in preterm infants with lower platelet counts.
High Incidence of Anticoagulation-Associated Abnormal Menstrual Bleeding in Women After Venous Thromboembolism
Researchers sought to determine whether there was a link between abnormal menstrual bleeding and treatment with anticoagulants for VTE.
Low-Quality Evidence Underlies Use of Intermittent Pneumatic Compression With Pharmacological Thromboprophylaxis for VTE
Researchers sought to determine whether the addition of IPC to thromboprophylaxis for prevention of VTE is based on sound evidence.
Vaccination Status Not Associated With Acute Thromboembolism Risk in COVID-19
Regardless of vaccination status, adults hospitalized for COVID-19 infection are at increased risk for acute thromboembolism
Pulmonary Embolism and Uterine Fibroid Rates Among Younger, Black Women
Researchers sought to examine characteristics of and outcomes for patients with venothromboembolism and concomitant fibroids or gynecologic cancers.
Most Patients With Cancer Unaware of Risk for Cancer-Associated Venous Thromboembolism
Researchers sought to determine whether patients with cancer were aware of their risk of developing cancer-associated venous thromboembolism.
Gab2 and MALT1 Influence Regulation of Thromboinflammation, Deep Vein Thrombosis
Researchers conducted an analysis of the Gab2-MALT1 pathway to determine whether it impacts the development of thromboinflammation and deep vein thrombosis.
Patterns Identified With Cerebral Venous Thrombosis in a Population-Based Study
Researchers sought to determine patters related to age and sex in outcomes for patients with CVT.
D-Dimer Levels Have Limited Value in Identifying Pulmonary Embolism in COVID-19
Researchers explored the use of D-dimer levels to rule out PTE in patients with COVID-19, as well as clinical associations between D-dimer levels and PTE.
Venous Thromboembolism Increasing in Inflammatory Bowel Disease Hospitalizations
Researchers assessed nationwide trends of venous thromboembolism-related hospitalizations among patients with inflammatory bowel disease.
Vaccination Status May Affect Venous Thromboembolism Risk in Ambulatory COVID-19
Researchers assessed the 30-day risk for VTE among ambulatory patients with COVID-19 and compared, via propensity-score matching, individuals without COVID-19 infection.
OAC in Patients With AF and COVID-19 Lowers Rates of Death, Thrombotic Events
Researchers assessed the relationship between oral anticoagulation for patients with COVID-19 and AF and incidence of in-hospital thrombotic events and death.
Tranexamic Acid Prophylaxis Does Not Improve Bleeding Risk for Thrombocytopenia in Hematologic Malignancies
Researchers sought to determine whether prophylactic tranexamic acid would improve bleeding outcomes in patients treated for hematologic malignancy at risk of thrombocytopenia.
Variable Dose Thromboprophylaxis May Increase Survival in Patients With COVID-19
Researched compared standard vs variable thromboprophylaxis strategies on the risk of mortality among patients hospitalized with COVID-19.
Lack of Treatment Consensus Highlights Unmet Need in Prenatal, Neonatal Alloimmune Thrombocytopenia
Researchers sought to describe contemporary management across international centers and evaluate outcomes among patients with FNAIT.
Can Pulmonary Embolism Severity Indices Predict COVID-19-Related Adverse Events?
Can the pulmonary embolism severity index assess the risk for adverse events among patients hospitalized for COVID-19 who are not diagnosed with PE or VTE?
Incidence and Predictors of Thrombotic Events in Secondary Myelofibrosis
Researchers sought to characterize the incidence and risk factors for thrombotic events in patients with secondary myelofibrosis.
Heparin in Adult Patients with COVID-19 and Hypercoagulation Complications
Investigators sought to assess the effectiveness of heparin in patients hospitalized with COVID-19 and hypercoagulation.
Pregnant Patients With HIV May Be at Risk of Impaired Fibrinolysis
Researchers sought to determine whether patients with virologically suppressed HIV were more likely to have impaired markers of fibrinolysis.
Neutrophil-to-Lymphocyte Ratio May Predict Thrombotic Events in Polycythemia Vera
Researchers sought to determine whether neutrophil-to-lymphocyte ratio would be predictive of thrombotic events in patients with polycythemia vera.
Enoxaparin’s Effect on VTE and Major Bleeding After Bariatric Procedure
Investigators sought to determine the safety and efficacy of varying doses of enoxaparin regimens in patients receiving a bariatric procedure.
Risk of Arterial Thrombosis Higher With COVID-19 in Patients With Myeloproliferative Neoplasms
Researchers sought to determine whether there was a higher risk of developing thrombosis in patients with MPNs and COVID-19.
Tavneos Approved for ANCA-Associated Vasculitis
The approval was based on data from the phase 3 ADVOCATE trial, which evaluated Tavneos in 330 adults with newly diagnosed or relapsed ANCA-associated vasculitis.
Neuropsychiatric Symptoms and Stroke in Patients With Hereditary Thrombotic Thrombocytopenic Purpura
Researchers sought to determine rates of stroke, stroke-related disability, and presence of neuropsychiatric symptoms in patients with hTTP.
Coagulation Parameters Similar With Dabigatran Treatment in Adults and Children
Researchers sought to determine the patterns of coagulation times with concentration of dabigatran in adults and children with VTE.
Race, Income, and Rurality Tied to Certified Stroke Centers in the US
In an observational study, researchers examined certified stroke center care access between historically underserved and general communities.
Second-Line Azathioprine Potential Option for Immune Thrombotic Thrombocytopenic Purpura
Researchers sought to determine whether azathioprine should be evaluated as an option for second-line therapy in patients with of immune-related TTP.
Should Alteplase Be Used With Endovascular Thrombectomy for Ischemic Stroke?
Researchers sought to determine whether prespecified outcomes were different in endovascular thrombectomy with alteplase compared with EVT alone in patients hospitalized with acute ischemic stroke.
Flow Cytometry-Based Method of Diagnosis Developed for Vaccine-Induced Immune Thrombotic Thrombocytopenia
Researchers sought to determine whether an assay using flow cytometry may help to diagnose patients who have vaccine-induced immune thrombotic thrombocytopenia.
Enoxaparin Prophylaxis Not Effective in At-Risk Outpatients With COVID-19
Researchers sought to determine whether prophylaxis with enoxaparin would be effective in outpatients with COVID-19.
OVID Findings Do Not Support Routine Use of Anticoagulant in Outpatients With COVID-19
Researchers sought to determine whether thromboprophylaxis with enoxaparin would reduce early hospitalizations and deaths among outpatients with symptomatic COVID-19.
Link Found Between Anti-Endothelial Cell Antibodies and Thrombosis With Polycythemia Vera
Researchers sought to determine whether there was a link between anti-endothelial cell antibodies and thrombosis in patients with polycythemia vera.
No Recurrence of VTE 1 Year after COVID-19-Associated VTE Event
A study was conducted to determine outcomes in hospitalized patients with COVID-19 and VTE, during anticoagulation therapy and at 1-year follow-up.
Avatrombopag Plus MSCs Improved Platelet Recovery After Allo-HSCT
Researchers sought to determine whether avatrombopag with MSCs would improve platelet recovery in patients with prolonged thrombocytopenia after allo-HSCT.
Study Finds Racial Disparities in Cancer-Associated Thrombosis
Researchers sought to determine whether the incidence of CAT was different across designated racial groups.
Deep Vein Thrombosis, Pulmonary Embolism, and Bleeding Risk in COVID-19
Researchers sought to determine the risk for pulmonary embolism, deep vein thrombosis, and bleeding in patients recovering from COVID-19 infection.
Are Amyloid Fibrin Microclots Central to Long COVID?
Researchers sought to determine the factors that contribute to patients developing clots from Long COVID.
Migraine and Posterior Circulation Ischemic Stroke: Is There a Genetic Overlap?
Researchers sought to assess whether patients with migraine had a greater risk for PCiS than ACiS and if patients genetically predisposed to migraine showed an increased risk for PCiS or ACiS.
Khorana Score Unable to Stratify Patients With Certain Cancer Subtypes by Risk of Venous Thromboembolism
Researchers sought to determine whether the Khorana score would be able to risk-stratify patients according to the 6-month risk of incident VTE.
Fondaparinux Appears More Cost Effective Than Argatroban in Suspected Heparin-Induced Thrombocytopenia
Researchers sought to determine whether fondaparinux would be a more cost-effective treatment compared with argatroban in patients with suspected HIT.
Anticoagulation in Non-ICU Patients With COVID-19 at High Thrombosis Risk
What is the best current strategy for addressing patients with COVID-19 who are at high risk for thrombosis but are not in the ICU?
Thromboembolic Events Among Patients Hospitalized With COVID-19 Pneumonia
Researchers assessed outcomes and risk factors associated with thromboembolic events among patients with COVID-19 pneumonia.
Survivors of Medulloblastoma Have Greater Risk of Stroke, Severe Hearing Loss
Medulloblastoma survivors had an increased risk of long-term adverse outcomes.
Momelotinib Demonstrates Superiority Over Danazol in Thrombocytopenic Myelofibrosis
Researchers sought to compare the efficacy of momelotinib with danazol in patients with thrombocytopenic myelofibrosis who were symptomatic and anemic.
Antimicrobial Peptide LL‑37 Contributes to Thrombotic Complications in Patients With COVID‑19
Researchers sought to determine the role of LL-37 in patients with SARS-CoV-2 infection and whether it contributes to hypercoagulation.
Catheter-Directed Thrombolysis Appears Safe and Effective for Postpartum Deep Venous Thrombosis
Researchers sought to determine whether catheter-directed thrombolysis would be effective in patients with postpartum iliofemoral deep venous thrombosis.
Addressing Psychological Distress After Venous Thromboembolism
Researchers are seeking to address the psychological impact of patients who have survived VTE.
Rilzabrutinib Shows Promise in Immune Thrombocytopenia
Researchers sought to determine whether rilzabrutinib would be effective in treating immune thrombocytopenia.
Efgartigimod Looks Promising for Primary Immune Thrombocytopenia
The phase 3 ADVANCE trial evaluated the efficacy and safety of efgartigimod in 131 adults with primary ITP.
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