Thrombotic Disorders

Therapeutic-Dose LMWH Cuts Thromboembolism, Deaths in COVID-19

Reduction in venous thromboembolism, arterial thromboembolism, and deaths seen in high-risk patients in non-ICU, but not ICU, settings.

Risk for NETosis and Thromboembolic Events in Patients With Myeloproliferative Neoplasms

By

Vicki Moore, PhD

Researchers sought to determine the risk for patients with MPNs to develop thromboembolisms, which may be associated with cell death related to a process called neutrophil extracellular trap formation.

VWF Associated With Thrombotic Complications in Patients With COVID-19

By

Patricia Chaney

Researchers sought to determine whether von Willebrand factor may be a potential target for therapies to address thrombotic complications in patients with COVID-19.

Sonothrombolysis Improves Odds of Complete Recanalization in Acute Ischemic Stroke

By

Brandon May

Researchers evaluated the safety and efficacy of sonothrombolysism, an ultrasound-enhanced thrombolysis, in patients with acute ischemic stroke with large vessel occlusion in randomized controlled clinical trials.

Characteristics and Risk Factors for Venous Thromboembolism With Intracerebral Hemorrhage

By

Vicki Moore, PhD

Researchers sought to determine risk factors for venous thromboembolism in patients with intracerebral hemorrhage.

Effect of Bundle Nursing on Thrombosis Risk in Patients With Non-Hodgkin Lymphoma

By

Jessica Nye, PhD

A single-institution study determined the effect of a novel nursing practice on incidence of PICC-UEDVT, outcomes, and satisfaction with care in patients with NHL.

Delayed Headache After Adenovirus Vector-Based COVID-19 Vaccine Is Associated With Cerebral Venous Thrombosis

By

Lauren Dembeck, PhD

Researchers sought to determine whether delayed onset of headache following vaccination with an adenovirus vector-based COVID-19 vaccine may be associated with development of CVT.

Incidence of Heparin-Induced Thrombocytopenia in Patients Hospitalized With COVID-19

By

Patricia Chaney

Researchers sought to determine the incidence of heparin-induced thrombocytopenia in patients hospitalized with COVID-19.

Peanut Consumption Linked to Reduced Stroke Risk in Japan

Association seen in men and women for higher peanut consumption with reduced risks of total stroke, ischemic stroke, cardiovascular disease.

Plasma Complement Component C5 Level and Venous Thromboembolism Risk

By

Vicki Moore, PhD

Researchers sought to determine if there was a link between plasma complement component C5 level and increased risk of venous thromboembolism.

Thrombopoietin Receptor Agonists Are Effective in Older Patients With Primary Immune Thrombocytopenia in the Real-World Setting

By

Lauren Dembeck, PhD

Researchers sought to determine whether thrombopoietin receptor agonists would be effective in older patients with primary immune thrombocytopenia in a real-world setting.

Study Identifies Characteristics Associated With Cerebral Venous Thrombosis in Patients With Myeloproliferative Neoplasms

By

Vicki Moore, PhD

Researchers characterized incidence and factors linked to cerebral venous thrombosis associated with myeloproliferative neoplasms.

Fluoxetine Does Not Decrease Symptoms of Clinical Depression in Patients After a Stroke

By

Jessica Nye, PhD

Researchers performed a secondary analysis of the AFFINITY trial that assessed the effects of fluoxetine treatment on depression symptoms in patients who recently had a stroke.

Dabigatran at 72 Hours Effective for Patients With Acute Intermediate-Risk Pulmonary Embolism

By

Vicki Moore, PhD

Researchers sought to determine whether early dabigatran would be effective and safe in patients with acute intermediate-risk pulmonary embolism.

Elevated Complement Factor Ba Predicts Transplant-Associated Thrombotic Microangiopathy

By

Lauren Dembeck, PhD

Researchers sought to determine whether Ba levels after allo-HSCT may serve as a prognostic biomarker of transplant-associated thrombotic microangiopathy.

Aspirin May Lower Risk of Thrombosis in Patients With COVID-19

By

Patricia Chaney

Researchers sought to determine whether low-dose aspirin may reduce thromboembolic events associated with COVID-19.

Early Central Venous Catheter Removal and Pulmonary Embolism Risk

By

Vicki Moore, PhD

Researchers sought to determine whether early central venous catheter removal would be linked to pulmonary embolism risk in patients with catheter-related upper extremity deep vein thrombosis.

SARS-CoV-2 Adenoviral Vector Vaccine-Induced Immune Thrombotic Thrombocytopenia: A Brief Case Report

By

Jessica Nye, PhD

Researchers sought to describe the first 3 patients in Canada who developed vaccine-induced immune thrombotic thrombocytopenia after receiving the adenoviral vector vaccine against COVID-19.

Vagus Nerve Stimulation System Approved for Post Stroke Rehabilitation Therapy

By

Brian Park, PharmD

The Vivistim System features an implantable pulse generator, which is placed just under the skin in the chest of the patient, and a lead wire.

Nomogram May Help Predict Deep Vein Thrombosis After Liver Surgery for Patients With Hepatocellular Carcinoma

By

Patricia Chaney

Researchers sought to determine whether a nomogram may be helpful to predict risk of DVT after laparoscopic hepatectomy in patients with HCC.

Thromboprophylaxis Is Safe and Effective in Patients With High-Risk Cancer

By

Lauren Dembeck, PhD

Intermediate anticoagulation doses appear to be safe and effective as thromboprophylaxis in patients with high thrombotic risk active cancer.

Effectiveness of Corticosteroids in the Treatment of Chemotherapy-Induced Thrombocytopenia

By

Lauren Dembeck, PhD

Researchers sought to determine whether corticosteroids would be an effective treatment for patients with chemotherapy-induced thrombocytopenia.

Patients With Cancer and COVID-19 Face Increased Risk of Thromboembolic Events

By

Jonathan Goodman, MPhil

Researchers sought to determine whether patients with cancer who had COVID-19 had an increased risk of experiencing thromboembolic events.

ASH Suggests Not Using Outpatient Thromboprophylaxis for COVID-19

For discharged patients without suspected or confirmed VTE or other indication for anticoagulation, panel suggests not using anticoagulants.

Prothrombic Immune Thrombocytopenia in Patients Following ChAdOx1 Vaccine

By

Vicki Moore, PhD

Researchers sought to identify the experiences of patients who developed prothrombotic immune thrombocytopenia after receiving the ChAdOx1 vaccine (AZD1222) against SARS-CoV-2.

AHA Presidential Statement: The Link Between Opioid Use, CVD, and Stroke

By

Inga Back, MPH

The AHA has issued a Presidential Advisory Statement outlining considerations for addressing the effects of opioids on cardiovascular and neurovascular health.

Features of Vaccine-Induced Thrombotic Syndrome Studied

No individual risk factors identified for VITT, but increased mortality seen for those with cerebral venous sinus thrombosis, low platelets.

Abelacimab Prevents VTE After Total Knee Arthroplasty

Single, postoperative IV dose of abelacimab superior to enoxaparin for preventing venous thromboembolism, with no increase in bleeding risk.

Prothrombotic Immune Thrombocytopenia Following COVID-19 Vaccination

By

Lauren Dembeck, PhD

Researchers sought to describe the unexpected autoimmune prothrombotic disorder experienced after vaccination with the ChAdOx1 COVID-19 vaccine.

Racial/Ethnic Disparities Seen in Anticoagulant Initiation for A-Fib

Disparities seen among VA patients both for initiating any anticoagulant therapy and for initiating direct-acting oral anticoagulant use.

Thrombotic Events Linked With Higher Mortality Among Pediatric Patients Hospitalized With COVID-19, MIS-C

By

Jonathan Goodman, MPhil

Researchers sought to determine the mortality rate for pediatric patients with COVID-19 or multisystem inflammatory syndrome in children who experience thrombotic events.

VTE Risk Up for Children With Inflammatory Bowel Disease

Venous thromboembolism occurred less often for those with Crohn disease versus ulcerative colitis

Guidelines for Management of Venous Thromboembolism in Latin America

By

Vicki Moore, PhD

A panel convened to develop guidelines for management of venous thromboembolism in the Latin American region.

Ethnically Diverse Study Finds COVID-19 Increases Risk of Venous Thromboembolism

By

Sheila Jacobs

Hospitalized patients with COVID-19 had a greater than 3-fold adjusted risk for venous thromboembolism compared with matched controls, the study found.

OAC Reduces Stroke Risk in AF or HFrEF Despite Greater Hemorrhage Risk

By

Brandon May

In a meta-analysis, researchers sought to further clarify the role of oral anticoagulation for preventing ischemic stroke in patients with AF and HFrEF.

Direct and Indirect Platelet Activation Drives Thrombosis in Hyperhomocysteinemia

By

Lauren Dembeck, PhD

Researchers sought to determine the mechanism through which hyperhomocysteinemia contributes to thrombosis, directly and indirectly activating platelets.

Disease Course, Risks Identified With Extrahepatic Portal Vein Thrombosis in Pediatric Patients

By

Vicki Moore, PhD

Researchers sought to identify aspects of the disease course and risk factors involved with extrahepatic portal vein thrombosis (EHPVT) in pediatric patients.

Venous Thromboembolism and Lung Ultrasound Findings With COVID-19

By

Vicki Moore, PhD

Researchers sought to determine the link between lung ultrasound findings and the development of VTE in patients with COVID-19.

Bullous Pemphigoid Linked to Preexisting Stroke, Malignancies

By

Colby Stong

A novel study asks: Does a correlation exist between preexisting comorbidities and serum titers of anti-BP180 and 230 antibodies in patients with bullous pemphigoid (BP)?

Managing Systemic Autoimmune Diseases Associated With Thrombotic Microangiopathy

By

Sheila Jacobs

Using data from the French National TMA registry, study authors evaluated the demographic and clinical characteristics of thrombotic microangiopathy in autoimmune diseases, and assessed therapeutic approaches.

Venous Thromboembolism or Major Bleeding Seen Frequently in Patients With Glioblastoma

By

Vicki Moore, PhD

Researchers sought to determine the rates of VTE and major bleeding in patients with glioblastoma.

Association of COVID-19 With Venous Thromboembolism Events in Hospitalized Patients

By

Lauren Dembeck, PhD

Researcher sought to determine the risk of developing VTE in patients with and without COVID-19 who were hospitalized.

CDKN2A Deletion Predicts Risk of Venous Thromboembolism in Patients With Glioblastoma

By

Jonathan Goodman, MPhil

Researchers sought to determine whether CDKN2A deletion could predict a higher risk of VTE in patients with glioblastoma.

Analysis of the NEOCLOT Protocol for Patients With Catheter-Related Venous Thrombosis

By

Vicki Moore, PhD

Researchers evaluated the NEOCLOT protocol for management of catheter-related venous thrombosis in neonates in the Netherlands.

More Clot Retrieval Attempts May Worsen Stroke Outcome

Number of clot retrieval attempts linked to infarct growth, which independently predicts unfavorable outcome in acute ischemic stroke.

Thromboses in Pediatric Patients With Myeloproliferative Neoplasms

By

Vicki Moore, PhD

Researchers sought to determine the occurrence of thrombotic events in a cohort of pediatric patients with myeloproliferative neoplasms.

Intravenous Immune Globulin for Vaccine-Induced Thrombotic Thrombocytopenia

By

Vicki Moore, PhD

Researchers described outcomes for 3 patients in Canada who were treated with high-dose IVIG for vaccine-induced immune thrombotic thrombocytopenia after receiving the ChAdOx1 nCoV-19 vaccine.

Anemia May Increase Risks of Ischemic Stroke and Poststroke Mortality

By

Vicki Moore, PhD

Researchers sought to determine whether patients with anemia had an increased risk of ischemic stroke and poststroke mortality.

Reduced Calf Muscle Pump Function Linked With Venous Thromboembolism Risk, Mortality

By

Jonathan Goodman, MPhil

Researchers sought to determine whether patients with reduced calf muscle pump function may be at an increased risk for venous thromboembolism.

Women Are Under-Represented in Acute Stroke Trials

By

Brandon May

This meta-analysis included patients with stroke and/or transient ischemic attacks to determine whether women are under-represented in clinical trials of acute stroke therapies.

Timely Endovascular Thrombectomy Imperative for Favorable Post-Stroke Outcomes

By

Jessica Nye, PhD

A team of investigators evaluated the lifetime outcomes linked to the speed of endovascular thrombectomy success in patients with acute ischemic stroke.