Thalassemias

Reducing Transfusion Burden and Addressing Unmet Needs in Beta Thalassemia

Lack of resources and poor awareness of thalassemia can make it difficult for patients with beta thalassemia to receive necessary blood transfusions.

White Matter Changes and Headache in Thalassemia

By

Sonali Gattani

Recurrent headache was reported by 61% of patients with thalassemia compared with 22.5% of healthy individuals in a control arm.

The Efficacy of Intrabone Gene Therapy for Transfusion-Dependent Beta Thalassemia

By

John Schieszer

Allogeneic HSC gene therapy may be an alternative to transplantation for patients with transfusion-dependent thalassemia.

Luspatercept May Improve Hemoglobin Levels in Patients With Beta Thalassemia

By

John Schieszer

A high percentage of patients with beta thalassemia demonstrated an increase in hemoglobin levels after receiving luspatercept.

New Iron Chelator May Improve Cardiac Function in Patients With Beta Thalassemia

By

Lauren Dembeck, PhD

A new oral iron chelator, deferasirox, may confer long-term benefits to patients with beta thalassemia major.

A Novel Health-Related Quality of Life Assessment Tool for Nontransfusion-Dependent Beta Thalassemia

By

Megan Garlapow, PhD

Modern tools for measuring health-related quality of life may not capture symptoms unique to patients with nontransfusion-dependent thalassemia.

Managing Atrial Fibrillation in Patients With Beta Thalassemia Major

By

Lauren Dembeck, PhD

Patients with beta thalassemia major may be at higher risk for atrial fibrillation, creating a need for attentive clinical management.

Peripheral Blood: An Alternative Source of Stem Cells in Thalassemia

By

Megan Garlapow, PhD

Accessing peripheral blood as a graft source is easier and less invasive than accessing bone marrow.

Serum Ferritin May Unreliably Predict Iron Overload in Patients with Thalassemia Major

By

Sonali Gattani

Iron overload that persists after HSCT can cause long-term organ damage.

Managing Medical Complications of Beta-Thalassemia in Adults: An Experience-Based Perspective

By

Lauren Dembeck, PhD

Mortality in beta-thalassemia has decreased due to medical advances, allowing physicians to observe and manage disease-related complications in adult patients.