Red blood cell alloantibodies were detected more than 4 times as frequently with flow cytometry compared with direct Coombs test.
Lack of resources and poor awareness of thalassemia can make it difficult for patients with beta thalassemia to receive necessary blood transfusions.
Recurrent headache was reported by 61% of patients with thalassemia compared with 22.5% of healthy individuals in a control arm.
Allogeneic HSC gene therapy may be an alternative to transplantation for patients with transfusion-dependent thalassemia.
A high percentage of patients with beta thalassemia demonstrated an increase in hemoglobin levels after receiving luspatercept.
A new oral iron chelator, deferasirox, may confer long-term benefits to patients with beta thalassemia major.
Modern tools for measuring health-related quality of life may not capture symptoms unique to patients with nontransfusion-dependent thalassemia.
Patients with beta thalassemia major may be at higher risk for atrial fibrillation, creating a need for attentive clinical management.
Accessing peripheral blood as a graft source is easier and less invasive than accessing bone marrow.
Iron overload that persists after HSCT can cause long-term organ damage.
Mortality in beta-thalassemia has decreased due to medical advances, allowing physicians to observe and manage disease-related complications in adult patients.