An overview of the diagnosis and management of MDS, including recent treatment, was discussed in a paper published in the American Journal of Hematology.
Researchers sought to determine whether TP53 mutations would be linked with more aggressive disease in patients with MDS or AML.
Researchers sought to determine whether elevated platelet-to-lymphocyte ratio and plasma C-reactive protein level would help predict prognosis for patients with MDS.
A head-to-head comparison of 7-day and 5-day treatment schedule of azacitidine in patients with higher risk myelodysplastic syndromes revealed trends in overall survival and time to transformation to leukemia.
Diagnosis, goals of care, and treatment options for MDS are discussed in a presentation at 2022 ONA Summit.
Researchers are trying to determine the optimal treatment strategy among patients with TP53-mutated AML or MDS.
Researchers sought to determine whether levels of apolipoprotein A1 would be prognostic for disease outcomes in patients with MDS.
Researchers sought to characterize features and outcomes specific to patients with MDS and MPNs with ring sideroblasts and thrombocytosis.
Researchers sought to identify features related to failure to reach allogeneic hematopoietic stem cell transplantation in patients with myelodysplastic syndromes.
Researchers sought to determine whether the tumor suppressor gene CADM1 would be a factor influencing MDS with del(11q).
Tamibarotene is an oral first-in-class selective retinoic acid receptor alpha (RARα) agonist.
Researchers sought to define the features and treatments for iron overload in patients with transfusion-dependent myelodysplastic syndrome.
Researchers sought to determine whether a machine learning-based model would be able to accurately predict the diagnoses of myeloid malignancies.
Researchers sought to determine whether nonablative chemotherapy followed by HLA-mismatched allogeneic T-cell infusion would be safe and effective in older patients with AML or MDS.
Researchers sought to determine the role of PARP1 in the physiological and pathological effects in MDS and AML.
As myeloproliferative neoplasms (MPN) are a particularly rare form of blood cancer without a clear cause, it may be difficult to understand how lifestyle factors can affect both MPN risk and symptom burden. What has research suggested about the ways certain lifestyle factors affect MPNs?
Researchers sought to determine the effects of TERT rare variants in patients with myelodysplastic syndrome.
Researchers sought to determine whether detecting MRD with mutational analysis and FCM may aid in predicting disease progression following myeloablative allo-HSCT in patients with MDS.
Researchers sought to determine whether allo-HSCT would negate poorer outcomes in patients with MDS who have myelofibrosis.
Researchers sought to determine whether APVO436 would have a favorable safety profile in treating patients with relapsed/refractory AML or MDS.
Researchers sought to determine how the bone marrow microenvironment contributes to the etiology of myelodysplastic syndrome.
Researchers sought to review the current understanding and available treatments of myelodysplastic syndromes as well as future perspectives.
As myeloproliferative neoplasms (MPNs) are a rare form of blood cancer, patients may not be aware of its effects. How do MPNs affect a patient’s quality of life, and what do your patients need to know?
Researchers seek to identify biomarkers that may be predictive of erythroid response in patients with lower-risk myelodysplastic syndromes without a chromosome 5q deletion.
Researchers sought to determine whether differences in treatment guidelines for MDS would account for nonadherence to expert guidance.
Researchers sought to identify inflammation-related genes that may be associated with leukemic transformation in patients with MDS with myelofibrosis.
Researchers sought to review the EU’s marketing authorization for luspatercept to treat select patients with MDS or transfusion-dependent beta thalassemia.
Researchers sought to determine whether
IRF4 expression is associated with an increased susceptibility to de novo AML and myelodysplastic syndrome.
Researchers found a high incidence of thromboembolic events in young patients with myeloproliferative neoplasms, especially polycythemia vera.
Researchers sought to determine whether pevonedistat plus azacitidine would result in a lower residual mutation load than seen with azacitidine alone in patients with MDS.
Researchers sought to determine whether there is a link between exposure to a soluble CD40 ligand (sCD40L) and expression of TNFα in bone marrow mononuclear cells from patients with MDS.
Researchers sought to determine what is the best method for detecting liver iron abundance in patients with MDS.
Researchers sought to determine whether an HSP90 inhibitor and a plant-derived coumarin would have antitumor effects in patients with MDS.
Researchers sought to determine what factors may help predict what patients with MDS or AML would respond to treatment with azacitidine.
Researchers evaluated the rates and significance of HFE variants in a population of patients with MDS.
Researchers sought to determine whether paroxysmal nocturnal hemoglobinuria clones might predict treatment responses for patients with MDS and aplastic anemia.
Researchers assessed if older patients with high-risk myelodysplastic syndrome experience significant overall survival benefit from hematopoietic transplantation.
A new study evaluated the prognostic value of the Fibrinogen-Albumin Ratio Index in certain conditions.
A team of researchers sought to determine whether morphologic dysplasia may serve as a biomarker of risk for transition to myelodysplastic syndrome in patients with clonal cytopenia of undetermined significance.
Observational, retrospective study revealed factors that may be linked to higher mortality risk in patients with MPN and COVID-19.
A team of investigators sought to evaluate outcomes following combination treatment with eprenetapopt and azacitadine in TP53-mutant myelodysplastic syndromes, as well as in oligoblastic acute myeloid leukemia.
A phase 3 trial suggests higher responses when epoetin alfa is added to lenalidomide in treatment of erythropoietin-refractory myelodysplastic syndromes.
Investigators estimated the risk for myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) related to PARP inhibition.
Among patients with myelodysplastic syndrome, long noncoding RNA
KIAA0125 may predict poorer overall survival and leukemia-free survival.
Researchers reviewed the challenges and future developments in ICI combination therapies for the treatment of patients with acute myeloid leukemia and myelodysplastic syndromes.
Although other flow cytometry–based prognostic scores have been proposed in the setting of MDS, their complexity has limited their clinical use.
There may be no relapse-free survival or overall survival benefits with posttransplant azaciditine in patients with high-risk AML or MDS.
Among some patients with myelodysplastic syndrome, gene expression signatures appear to be predictive of response and primary resistance to azacitidine.
With the exception of alloSCT and iron chelation therapy, many guideline treatments may not improve survival among patients with myelodysplastic syndrome.
Researchers studied survival in reduced-intensity conditioning HSCT vs non-HSCT approaches for older, transplantation-eligible patients with advanced MDS.
The first-in-class imetelstat demonstrated clinically meaningful red blood cell transfusion independence rates in lower-risk MDS, according to results of a phase 2 trial.