Two single-nucleotide polymorphisms (SNPs) are associated with progression-free survival (PFS) among patients with diffuse large B cell lymphoma (DLBCL) receiving R-CHOP [rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone], according to a poster presented at the 2017 Hematology/Oncology Pharmacy Association (HOPA) Annual Conference.1

For this retrospective study, researchers analyzed DNA samples from 166 patients with newly diagnosed DLBCL treated with R-CHOP to determine whether any of 11 SNPs was associated with a response to treatment.

Mean PFS was 957 days. Two SNPS (rs4880 and rs1870377) had an association with PFS: the CC mutation of rs4880 was linked to worse PFS, possibly due to increased resistance to cyclophosphamide and doxorubicin, and the AA allele of rs1870377 was linked to better PFS.

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The researchers concluded that while an association was found between PFS and these SNPs, further study is needed for confirmation.

Reference

  1. Zheng K, Hu Y, New-aaron M, Yee GC, Meza JL. Pharmacogenomics of R-CHOP in patients with diffuse large B-cell lymphoma. Poster presented at: 13th Hematology/Oncology Pharmacy Association Annual Conference; March 29-April 1, 2017; Anaheim, CA.

This article originally appeared on Cancer Therapy Advisor