A recent study found that children with chronic myeloid leukemia (CML) may show signs of acquired von Willebrand syndrome (AVWS). The results were reported in the British Journal of Haematology.1
In this retrospective analysis (ClinicalTrials.gov Identifier: NCT00445822), 156 pediatric patients below the age of 18 years upon a diagnosis of CML were evaluated for platelet counts and associated hematologic parameters.
The CML stage was chronic phase in 146 patients, blast phase in 7 patients, and accelerated phase in 3 patients.
Among patients with chronic phase CML, 55.5% had thrombocytosis. In total, 51% of patients exhibited thrombocytosis, which occurred to an extreme level (> 1000 x 109 platelets/L) in 16% of the patient population. The median platelet count overall was 483 x 109/L.
There were no reported incidences of thrombosis, but 12% of patients with thrombocytosis demonstrated mild bleeding. Bleeding symptoms appeared unrelated to higher platelet counts.