(HealthDay News) — High-titer COVID-19 convalescent plasma seems safe when given to high-risk children, but recipient plasma neutralization titers decline rapidly, according to a study recently published in JCI Insight.

Oren Gordon, M.D., Ph.D., from the Johns Hopkins University School of Medicine in Baltimore, and colleagues prospectively enrolled high-risk children to receive high-titer COVID-19 convalescent plasma. For up to two months after transfusion, the passive transfer of antibodies and endogenous antibody production were serially evaluated.

Overall, 14 high-risk children received high-titer COVID-19 convalescent plasma: nine within five days of symptom onset and five within four days after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exposure. The researchers found that no serious adverse events related to transfusion were reported. Antibodies to SARS-CoV-2 were transferred to the recipients, but by 14 to 21 days, the titers declined (half-life for spike protein immunoglobulin G, 15.1 days). Donor plasma had significant neutralization capacity; although this was transferred to the recipient, recipient plasma neutralization titers were 6.2 percent of donor titers as early as 30 minutes after transfusion.


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“Achieving higher neutralization titer in recipients will require the use of plasma with much higher neutralizing titers, such as that obtained from individuals who had COVID-19 and were subsequently vaccinated,” the authors write. “These data suggest that current use of convalescent plasma in high-risk children may only achieve low titers of neutralizing antibody.”

One author is cofounder of Pumas-AI and Vivpro Corp.

Abstract/Full Text