HealthDay News — Among pediatric cancer patients, overall morbidity of COVID-19 is low, according to a research letter published online May 13 in JAMA Pediatrics.

Farid Boulad, MD, from the Memorial Sloan Kettering Cancer Center in New York City, and colleagues performed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing among pediatric cancer patients presenting for outpatient or inpatient care who had been exposed to COVID-19 or who had symptoms of infection; asymptomatic patients prior to deep sedation, myelosuppressive chemotherapy, or hospital admission; and caregivers accompanying patients for admission or multiday chemotherapy. A total of 335 tests for SARS-CoV-2 were performed on pediatric patients and their caregivers between March 10 and April 12, 2020.

The researchers found that 11.2% of the 178 unique pediatric patients had positive test results. The rate of positivity for SARS-CoV-2 was 29.3% among patients specifically tested for positive screening or symptoms. In contrast, the rate of positivity was only 2.5% among 120 asymptomatic patients without known exposure. Only 3 of the 20 patients who tested positive for SARS-CoV-2 were female (15% compared with 43% of those who tested negative). One patient with COVID-19 required non-critical care hospitalization for COVID-19; 3 patients were admitted for concomitant fever and neutropenia, cancer morbidity, or planned chemotherapy. Overall, 13 of the 74 adult caregivers tested were positive for SARS-CoV-2.

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“Our results do not support the conjecture that children are a reservoir of unrecognized SARS-CoV-2 infection,” the authors write.

Abstract/Full Text