Long-term oral anticoagulation with vitamin K antagonists is recommended for most patients with myeloproliferative neoplasms experiencing thrombosis.
Although some red blood cell-related parameters used in the diagnosis of PV may be misleading in the setting of iron-deficiency, RBC count may be an effective biomarker for PV when combined with ESR.
This nonrandomized study enrolled more than 100 patients with essential thrombocythemia or polycythemia vera resistant to or intolerant of hydroxyurea to determine if interferon alfa-2a is effective in these patients.
An investigational gene therapy has been granted Orphan Drug designation from the Food and Drug Administration for the treatment of Gaucher disease.
Patients with viral respiratory infections exhibited poorer outcomes following transplantation compared with patients without infection.
Poverty was associated with lower rates of allogeneic hematopoietic stem cell transplantation, even after adjusting for race and rural residency.
Patients with blood cancers were more likely to enroll in hospice earlier if they included a hematologic oncologist in their first discussion about their goals of care.
Patients demonstrated similar rates of live births and thrombotic complications, but the most common complication was different for each group.
Researchers found a 1.12 ratio of blood product need to supply, and 61% of countries included in the analysis had an insufficient supply of blood products.
Red blood cell distribution width above the calculated cutoff of 13.8% was significantly associated with poorer overall survival.
Older patients with AF who have contraindications to oral anticoagulation because of high bleeding risk have increased mortality compared with untreated patients who have no contraindications.
In a retrospective service evaluation of patients with MPNs, researchers found that low-dose methotrexate eased symptom burden of comorbidities not related to the patient’s MPN.
Results of the PRISM-P trial compared the benefits parents of children with cancer derived from resilience training in a 1-on-1 setting vs group setting vs usual psychosocial care alone.
Patients who reinitated treatment less than a week after experiencing gastrointestinal bleeding experienced fewer ischemic events.
Several novel treatment agents for myeloproliferative neoplasms are currently being studied in phase 1 or phase 2 trials.
Researchers assessed patterns of genetic mutations and their prognostic effects in patients with primary and secondary myelofibrosis.
In this prospective study, researchers investigated the incidence of pulmonary hypertension among patients with MPNs. Their results led them to recommend systematic screening in this patient population.
An overview of the findings of an expert panel that examined the unmet clinical needs for patients with Ph-negative MPNs to assess for risks of thrombosis.
A report on oncofertility identifies the optimal multidisciplinary team for assuring that young patients with cancer can preserve their fertility and the options available to them for family building.
Due to conflicting literature, there is currently no consensus on the appropriate standard of care for managing polycythemia vera.
Certain malignancies, younger age at diagnosis, and multiple affected relatives were all associated with increased familial relative risks.
Of 5 patients with amyloid light-chain amyloidosis who received carfilzomib, all achieved very good partial response or better.
The longitudinal assessment option would allow physicians to engage with medical knowledge and resources at their own pace.
The FDA has approved Inrebic (fedratinib; Celgene) capsules to treat adult patients with intermediate-2 or high-risk primary or secondary (post-polycythemia vera or post-essential thrombocythemia) myelofibrosis.
Cumulative incidence of acute graft-versus-host disease within 100 days of transplant was 26% in the sirolimus group and 52% in the control group.
The use of levofloxacin as prophylaxis for the prevention of neutropenic fever and bloodstream infections was associated with less disruption of the gut microbiome in patients with hematologic malignancy.
An expanded treatment protocol study sought to validate the safety and efficacy of ruxolitinib, a JAK kinase inhibitor approved by the FDA for the treatment of polycythemia vera in patients who are intolerant of, or resistant to, hydroxyurea.
Researchers identified 3 prognostic factors predictive of all-cause mortality in multivariate analyses.
Oncology nurses discuss the importance of ongoing education on the treatments, symptoms, and available information on MPNs for patients, and oncology nurses.
Patients with secondary Evans syndrome demonstrated increased mortality compared with all other cohorts.
The Food and Drug Administration (FDA) has granted Fast Track designation to nipocalimab (M281) for the prevention of hemolytic disease of the fetus and newborn (HDFN).
Oncologists are changing the way they treat, perhaps too quickly and with too little evidence — but the behavior may signal a bigger problem with how research is reported.
Overall survival of 15 years or longer was reached by 30% of patients with amyloid light-chain amyloidosis who underwent autologous stem cell transplant.
Patients with between 0, 1, 2, or 3 controlled blood counts reported similar scores on the symptom severity survey used in the study.
According to a study published in Psycho‐Oncology, patients with newly diagnosed malignant lymphoma or multiple myeloma who reported depressive symptoms prior to the start of chemotherapy had poorer survival compared with patients who were not initially depressed. The prospective analysis was conducted at the Nagoya City University Hospital in Japan. Researchers sought to investigate the…
A decrease in gait speed by 0.1 m/s was associated with increases in mortality and utilization of emergency and acute care.
Determining the type of cell infected with Epstein-Barr virus (EBV) in peripheral blood mononuclear cells (PBMCs) proves to be a valuable tool for improving the differential diagnosis of hematologic disease with concurrent EBV infection, according to study results published in Open Forum Infectious Diseases. EBV is a herpesvirus that infects approximately 90% of the population…
A total of seven evidence based interdisciplinary recommendations for management of henoch-schönlein purpura have been formulated.
Hemolytic anemia and immune thrombocytopenic purpura were the most common complications of immune checkpoint inhibitor therapy.
Pediatric essential thrombocythemia is usually low risk; watching and waiting is a feasible management approach for asymptomatic patients.
Patients with atrial fibrillation and cancer may be at higher risk for thromboembolic events.
Busulfan plus melphalan may be a viable pretreatment conditioning regimen for patients undergoing autologous hematopoietic stem cell transplantation.
Patients who developed cerebrovascular disease following allogeneic hematopoietic stem cell transplantation experienced decreased survival.
Investigators estimated the effects of immunosuppression on poor outcomes in multiple cutaneous squamous cell carcinoma.
Twitter is increasingly being used by oncologists as a tool to communicate advancements in in the treatment of cancer. What could go wrong?
Though adoptive T-cell transfer has demonstrated clinical applicability, many barriers prevent it from becoming a standard of care following transplant.
No difference was observed in relapse risk or survival between patients receiving phenytoin and patients receiving alternative antiepileptic medications.
Mechanical circulatory support (MCS) devices can lead to hemostatic events, making it crucial to include a hematologist on a patient’s MCS management team.
Adhering to mucormycosis treatment guidelines may be difficult for physicians because of the complexity of the disease.
Researchers found no evidence that neutropenic and non-neutropenic patients with sepsis should be treated differently.
Current transfusion recommendations do not adequately inform transfusion in patients with hematologic malignancies, who are increasingly treated as outpatients.