How Doctors Can Cope With Psychological Distress During the Pandemic
When talking about work issues, Dr Bernstein recommends trying not to focus too much on how awful things are because it can be disheartening.
General Hematology
GENERAL HEMATOLOGY
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Siltuximab for Patients With Idiopathic Multicentric Castleman Disease
Researchers evaluated an approach to treatment guided by histopathologic subtype in patients with idiopathic multicentric Castleman disease.
FDA Requires Boxed Warning Update for Benzodiazepines
Benzodiazepines are widely used to treat a variety of conditions including anxiety disorders, insomnia and seizures.
Acute Medical Oncology Admissions During the COVID-19 Pandemic
Patients in Ireland logged shorter hospital stays and had fewer emergency department visits during the COVID-19 pandemic.
Germline Factors Affect Molecular Response to Treatment for Polycythemia Vera
Germline polymorphisms can affect response to treatment in people with polycythemia vera.
Tenapanor Under Review for Hyperphosphatemia in CKD
Tenapanor is a first-in-class oral medication that works by blocking the NHE3 transporter in the gastrointestinal tract.
FDA to Review Avacopan for ANCA-Associated Vasculitis
Avacopan is an orally-administered, small molecule designed to selectively block the complement 5a receptor on destructive inflammatory cells such as blood neutrophils.
Communicating With Patients in Oncology About Care During the COVID-19 Pandemic
How to explain adjustments to cancer care due to the COVID-19 pandemic and ease patients’ fears about the impact of those changes.
IT Asset Inventories Are a First Step in Securing Health Information
Practices need to know all of the components of their health information systems to determine potential vulnerabilities.
A New Hope for IL-18 Therapy
Engineered cytokine evades the tumor’s defenses and boosts the production of stem-like polyfunctional T cells.
COVID-19, SARS-CoV-2 Infection Phenotypes Vary With Different Tumor Subtypes
Among patients with cancer, tumor subtypes may influence varying susceptibility to SARS-CoV-2 and COVID-19 disease phenotypes.
Fostering Trust Between Parents of Children With Cancer and Physicians
Although most parents of children with cancer form trusting relationships with their children’s oncologists, poor outcomes may negatively affect this.
Are Preoperative 3D Reconstructions of Pediatric Tumors Helpful?
Researchers assessed the advantages and discrepancies of preoperative 3D reconstruction compared with 2D images and surgical findings in pediatric tumors.
Vadadustat Noninferior to Darbepoetin in CKD
Despite favorable efficacy data, the HIF-PHI failed to demonstrate noninferiority to the ESA in patients with CKD with respect to the primary MACE safety endpoint.
Glycemic Variability and Pediatric Hematopoietic Stem Cell Transplantation
Glycemic variability is suggested to be a risk factor for complications with hematopoietic stem cell transplantation in pediatric patients.
Label Mix-Up Prompts Recall of IV Amiodarone, Tranexamic Acid
Inadvertent administration may result in serious adverse events.
Three Additional Presentations of Vanco Ready Approved
The new doses of Vanco Ready include 150mL, 250mL, and 350mL premixed bags containing 750mg, 1.25g, and 1.75g of vancomycin, respectively.
Clonal Hematopoiesis in Hematologic Malignancies, Bone Marrow Failure Syndromes, and Stem Cell Clones
Recent studies have better elucidated the link between clonal hematopoiesis and hematologic malignancies.
Immune Selection in Younger, Female Patients May Affect Driver Mutations
Immune selection in younger and female patients may influence driver mutations that persist, possibly affecting response to immune checkpoint blockade.
Scientists Issue Call to Become “Antiracist” in Cancer Care and Research
Even with an “exponential growth” of URM students, “faculty diversity would remain static well into the next 50 years.”
Effects of ABO Blood Group on von Willebrand Factor Biology, Primary Hemostasis
ABO blood group has been associated with cardiovascular disease and thrombotic risk; however, influences on hemostasis are still not well understood.
Understanding the Association Between COVID-19, Thromboembolism, and Therapeutic Anticoagulation
In expanded research, investigators studied the effects of therapeutic and prophylactic anticoagulation treatment in hospitalized patients with COVID-19.
The Psychology of Collecting Debt: How to Get Patients to Pay Their Bills
By connecting on a personal level, medical practices may have better results in getting patients to settle their accounts.
Emergency Use Authorization Issued for COVID-19 Convalescent Plasma
The EUA was based on historical evidence indicating some effectiveness with convalescent plasma use in previous outbreaks of respiratory viruses, preclinical data, results from small clinical trials, and data from the National Expanded Access Treatment Protocol sponsored by the Mayo Clinic.
Hemophagocytic Lymphohistiocytosis: Pretransplant Analyses May Prevent Unnecessary HSCT
In a large prospective study, investigators assessed whether pretransplant analyses could prevent unnecessary HSCT in children with HLH.
The Twitter Effect on How Oncologists Conduct and Share Research
The social media platform can be useful as an education tool for oncologists to stay up to date on new research in oncology — but physicians still need to be mindful of the information sources.
Low-Molecular-Weight Heparin for Slow-Form Vascular Malformations Undergoing Sclerotherapy
Investigators characterized hematologic complications of sclerotherapy in patients with slow-form vascular malformations.
Possible Myeloid Progenitor Cells Involved in Langerhans Cell Histiocytosis
A progenitor population of cells may serve as a carrier of mutations involved in the development of both high-risk and low-risk Langerhans cell histiocytosis.
Trends in Opioid Use, Misuse Among Cancer Survivors in the United States
Investigators aimed to compare the prevalence and likelihood of opioid use and misuse among cancer survivors and those without cancer.
Hearing Loss Associated With Neurocognitive Deficits in Pediatric Cancer Survivors, Study Finds
A large cross-sectional cohort study investigated the relationship between hearing loss and measures of neurocognition in survivors of childhood cancers.
Pyruvate Kinase Deficiency: Current and Prospective Treatment Options
As PKD directly affects the catalysis of substrates and products involved in the production of ATP, the glycolytic pathway is compromised, thus leading to several cellular defects.
Development of a Tool to Predict Neurotoxicity Associated With CAR-T Therapy
The occurrence, severity, and need for treatment of cytokine release syndrome were key parameters in the assessment of CAR-T–related neurotoxicity risk.
Prevalence of Endotheliopathy in COVID-19–Associated Coagulopathy
A team of investigators sought to determine whether endotheliopathy is involved in COVID-19–associated coagulopathy pathogenesis.
MASCC Survey Identifies Research, Development Goals for Cancer Survivorship Care
A survey of MASCC clinician members identified 3 areas for further research and development to improve survivorship care plans for cancer survivors.
Reducing Time to Alkalinization Prior to HD-MTX Does Not Reduce Hospital Length of Stay
Adding acetazolamide reduced time to alkalinization, allowing for earlier administration of high-dose methotrexate; however, it did not reduce overall hospital length of stay.
Endogenous Topical Serum Preparations Retain Biological and Physiochemical Properties Following 6-Month Storage
Endogenous serum formulations may be used as a novel delivery system for skin regeneration in chronic diseases.
Protecting Practices From Ransomware
Hackers have penetrated healthcare providers’ computer systems to encrypt information and demand money for its release.
Daprodustat Noninferior to ESA in Hemodialysis Cases
In a phase 3 trial, mean hemoglobin was maintained within target range during 52 weeks of treatment with oral daprodustat.
How Patients Lose Their Own Voices: Disparities in Patient-Reported Outcome Capture in Clinical Trials
It remains important to interrogate how structural discrimination influences the collection of patient-reported outcomes.
Assessing Prevalence and Treatment of Cold Agglutinin Disease in Warmer and Colder Climates
Investigators aimed to improve the understanding of the epidemiologic, clinical, and laboratory findings of cold agglutinin disease.
Restructured Process Overcomes Barriers to Prior Authorization for Proton Therapy
This study examined the impact of a restructured prior authorization process on the delivery of PBT at a proton therapy center.
Characterization of NBEAL2 Genetic Variants in Gray Platelet Syndrome
In addition to well-described platelet defects in gray platelet syndrome, immune defects, such as abnormal cells also exist.
New Evidence Supports Update of ASCO Guidelines on Prevention, Treatment of CIPN
A literature search of new studies clarifies, refutes, and expands on previous recommendations for managing new and established CIPN in patients treated with cytotoxic agents.
DEA Warns of Extortion Scam Targeting Healthcare Providers
The DEA has issued a warning concerning an extortion scam involving calls from someone purporting to be a DEA agent attempting to extort money.
COVID-19 Vaccine Candidate Provides Protection in Animal Challenge Study
Vaccination with mRNA-1273, Moderna’s coronavirus disease 2019 (COVID-19) vaccine candidate, led to robust immune responses and protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in nonhuman primates.
Respiratory Sampling Strategies for Detecting SARS-CoV-2 Compared
Sputum sampling was found to be a valuable method for diagnosing and monitoring patients with coronavirus disease 2019 (COVID-19), according to a recent systematic review and meta-analysis published in EBioMedicine.
Prepare to E-Prescribe Controlled Substances
Beginning January 1, 2021, a federal law called the Every Prescription Conveyed Securely Act takes effect requiring that prescriptions for controlled substances covered under Medicare be prescribed electronically.
Pfizer, BioNTech Select COVID-19 Vaccine Candidate, Initiate Phase 2/3 Study
Pfizer and BioNTech have selected a coronavirus disease 2019 (COVID-19) vaccine candidate and have initiated their phase 2/3 safety and efficacy trial.
Fertility Preservation Counseling Before Chemotherapy May Be Infrequent
Clinicians are more likely to counsel younger and female patients on reproductive risks before initiating chemotherapy, despite available ASCO guidelines.
Cutaneous AEs Are Common in Patients With MPNs Treated With Hydroxyurea
Previously conducted retrospective studies may have underestimated the incidence of hydroxyurea-related skin toxicity in patients with MPNs.
Inolimomab BLA Submitted for Graft vs Host Disease
The BLA submission includes data from a phase 3 study comparing inolimomab to antithymocyte globulin in 100 adults with steroid-refractory aGVHD.
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