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General Hematology
GENERAL HEMATOLOGY
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Do Dietary Factors Influence Risk of Developing MPNs?
An analysis of data from the NIH-AARP Diet and Health Study evaluated the association between consumption of various foods and the development of MPN.
ACIP: COVID-19 Vaccine Should Be Offered to HCPs, LTC Residents First
The recommendation was made based on the number of confirmed COVID-19 cases among these 2 groups, as well as ethical and scientific considerations.
Authors at Gynecologic Oncology Meeting Fail to Disclose Industry Relationships
Most study authors at the 2019 Society of Gynecologic Oncology Annual Meeting failed to disclose industry relationships, a study found.
Management of AL Amyloidosis, Immunoglobulin Deposition Disease During the COVID-19 Pandemic
The management of AL amyloidosis and immunoglobulin disease during the COVID-19 pandemic should be individualized based on several patient-specific aspects.
FDA Authorizes COVID-19 Test That Provides Rapid Results at Home
This is the first time the Agency has authorized a COVID-19 diagnostic test that provides rapid results at home.
Conditioning With Alkylating Agents Prior to Transplant for Myelofibrosis
Patients with myelofibrosis conditioned with 2 alkylating agents may have better transplant outcomes compared with patients receiving 1 alkylating agent.
Integrative Medicine Therapies Effectively Increase Quality of Life for Patients With Myeloproliferative Neoplasms
An evaluation of more than 2 dozen types of integrative medicine therapies demonstrated that patients with MPNs who engaged in these activities had improved negative symptoms and quality of life.
Diagnostic Approach to Severe Reactive Hemophagocytic Lymphohistiocytosis
Researchers devised a comprehensive diagnostic approach to evaluating severe reactive hemophagocytic lymphohistiocytosis.
Interim Data Show COVID-19 Vaccine Candidate mRNA-1273 Near 95% Effective
The placebo-controlled COVE study is investigating the efficacy and safety of mRNA-1273 at the 100mcg dose (given intramuscularly in a 2-dose series, approximately 28 days apart) in more than 30,000 adults aged 18 years and older.
Prevalence of Pulmonary Hypertension in Patients With Myeloproliferative Neoplasms
A new meta-analysis indicates that the true prevalence of pulmonary hypertension linked to myeloproliferative neoplasms is not well understood.
Promising Early Results for Ruxolitinib-Decitabine Combination in MPN in Accelerated and Blast Phases
A small, single-arm, phase 2 study results demonstrate efficacy and safety of this combination therapy in patients with MPN-AP or MPN-BP.
Polycythemia Vera and Essential Thrombocythemia: Diagnosis, Risk-Stratification, Management Updates
Investigators summarized current literature surrounding the diagnosis and risk-stratification of PV and ET, and reviewed available and upcoming therapies.
COVID-19 Vaccine Candidate More Than 90% Effective, Say Pfizer, BioNTech
The trial will continue as planned and final analysis is expected when the number of confirmed COVID-19 cases reaches 164.
Survey Reveals Patient Concerns Around Type 1 Gaucher Disease
The use of patient-reported outcome measures specific to GD1 appears to capture health-related quality of life related issues that may otherwise be missed.
Assessment and Management of Patients with Polycythemia Vera
Some pointers from a review of assessment and management strategies for nurses caring for patients with polycythemia vera.
Long-Term Art Therapy Establishes Community Relationships Among Patients With Cancer
Researchers sought to determine the benefits of longer-term therapeutics for patients with cancer.
British Society of Haematology Issues Updated Guidelines for Irradiated Blood Components
The British Society of Hematology has updated their guidelines on the use of irradiated blood components.
Depression Common Among Patients With a Myeloproliferative Neoplasm
Using validated tools, investigators determined that patients with a MPN were likely to experience significant symptoms of depression.
Rivaroxaban sNDA Submitted for Symptomatic Peripheral Artery Disease
The application is supported by data from the double-blind, placebo-controlled phase 3 VOYAGER PAD trial.
Extensive Molecular Characterization Uncovers Actionable Alterations in Many High-Risk Pediatric Cancers
As part of the Zero Childhood Cancer Program, high-risk pediatric tumors were characterized by whole-genome sequencing, RNA sequencing, and methylation profiling.
Machine Learning Helped Predict Short-Term Cancer Mortality
Use of the algorithm could lead to improved use of supportive care.
Geriatric Assessment Instruments Underutilized Among Community Oncologists, Hematologists
Research presented at ASCO Quality Care Symposium revealed a need for better education regarding geriatric assessment tools among oncology clinicians.
COVID-19–Free Surgical Pathways Benefit Patients Undergoing Elective Cancer Surgery
Elective cancer surgery within COVID-19–free surgical pathways results in lower pulmonary complication, SARS-CoV-2 infection, and mortality rates.
Underrepresentation of Women in Clinical Trials Persists
Clinical trials leading to US FDA approvals of anticancer therapies continue to underrepresent women.
Hematologic Response, Free Light Chain Levels May Predict Overall Survival in AL Amyloidosis
AL amyloidosis patients with hematologic response and low serum free light chain levels may have longer OS.
FDA, EMA Call for Coordinated Submission of Plans to Study Pediatric Cancers
The FDA and EMA expressed the need for trial sponsors to coordinate their submissions of initial pediatric study plans and pediatric investigation plans for new oncology drugs.
Early Study Termination Muddles Benefit of Hydrocortisone in COVID-19
Patients with severe COVID-19 may benefit from a fixed-dose or shock-dependent dosing of hydrocortisone, but early study termination hindered definitive conclusions.
Most Coronavirus-Positive Cancer Patients Are Asymptomatic, Says Study
An analysis showed that outcomes of SARS-CoV-2 infections can be disproportionately mild in some patient cohorts.
FDA: More Data on Remestemcel-L for Graft-vs-Host Disease Needed
In the CRL, the FDA recommended that the Company conduct at least 1 additional randomized, clinical study.
Interferon Alpha and Pegylated Interferon Alpha Can Be Safe, Effective for Treatment of Essential Thrombocythemia and Polycythemia Vera
Interferon-alpha and pegylated interferon-alpha, as well as hydroxyurea and anagrelide, represent cytoreductive approaches to the treatment of patients with ET and PV.
SARS-CoV-2 Antibody Testing Linked to Increase in First-Time Blood Donors
Antibody testing after the early stages of the SARS-CoV-2 pandemic has significantly increased in the proportion of first-time blood donors.
Gene Expression in Patients With Severe Scleroderma May Predict Stem Cell Transplant Response
Researchers determined whether machine learning could predict stem cell transplant response in severe scleroderma.
Prevalence and Risks of Discordant Antibiotic Therapy for Bloodstream Infections
Researchers conducted a retrospective cohort analysis to assess the prevalence and effects of inappropriate empirical antibiotic therapy for bloodstream infections.
Risk of SARS-CoV-2 Contamination in Radiation Oncology Clinics
While several studies have investigated SARS-CoV-2 contamination in health care settings, patterns in oncology clinics with fewer COVID-19 cases is unclear.
Oral Chemotherapy Coordinator Improves Adherence, Adverse Effect Management
Implementing a role especially for helping patients manage their oral chemotherapy improved adherence, AE management, and other challenges patients experience.
Haegarda Approved for Pediatric Hereditary Angioedema
The expanded approval was based on data from the pivotal phase 3 COMPACT study and the COMPACT open-label extension study.
Cannabis Use May Decrease Efficacy of Immunotherapy
Cannabis use was associated with poorer outcomes with immune checkpoint inhibitors among patients with advanced cancers.
FDA Approves Nucala for Hypereosinophilic Syndrome
The FDA has approved Nucala (mepolizumab; GlaxoSmithKline) for the treatment of hypereosinophilic syndrome (HES) for 6 months or longer without another identifiable non-blood related cause of the disease in patients aged 12 years and older.
Siltuximab for Patients With Idiopathic Multicentric Castleman Disease
Researchers evaluated an approach to treatment guided by histopathologic subtype in patients with idiopathic multicentric Castleman disease.
How Doctors Can Cope With Psychological Distress During the Pandemic
When talking about work issues, Dr Bernstein recommends trying not to focus too much on how awful things are because it can be disheartening.
FDA Requires Boxed Warning Update for Benzodiazepines
Benzodiazepines are widely used to treat a variety of conditions including anxiety disorders, insomnia and seizures.
Acute Medical Oncology Admissions During the COVID-19 Pandemic
Patients in Ireland logged shorter hospital stays and had fewer emergency department visits during the COVID-19 pandemic.
Germline Factors Affect Molecular Response to Treatment for Polycythemia Vera
Germline polymorphisms can affect response to treatment in people with polycythemia vera.
Tenapanor Under Review for Hyperphosphatemia in CKD
Tenapanor is a first-in-class oral medication that works by blocking the NHE3 transporter in the gastrointestinal tract.
FDA to Review Avacopan for ANCA-Associated Vasculitis
Avacopan is an orally-administered, small molecule designed to selectively block the complement 5a receptor on destructive inflammatory cells such as blood neutrophils.
Communicating With Patients in Oncology About Care During the COVID-19 Pandemic
How to explain adjustments to cancer care due to the COVID-19 pandemic and ease patients’ fears about the impact of those changes.
IT Asset Inventories Are a First Step in Securing Health Information
Practices need to know all of the components of their health information systems to determine potential vulnerabilities.
A New Hope for IL-18 Therapy
Engineered cytokine evades the tumor’s defenses and boosts the production of stem-like polyfunctional T cells.
COVID-19, SARS-CoV-2 Infection Phenotypes Vary With Different Tumor Subtypes
Among patients with cancer, tumor subtypes may influence varying susceptibility to SARS-CoV-2 and COVID-19 disease phenotypes.
Fostering Trust Between Parents of Children With Cancer and Physicians
Although most parents of children with cancer form trusting relationships with their children’s oncologists, poor outcomes may negatively affect this.
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