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General Hematology
GENERAL HEMATOLOGY
FEATURE
LATEST NEWS
Update on Therapeutic Options for Myelofibrosis
A review of myelofibrosis, including an update on treatment options, was presented at the 2023 ONA Summit.
Patterns of COVID-19 Vaccination in Cancer Patients Who Already Had COVID-19
Several factors influenced the likelihood of COVID-19 vaccination among patients with cancer who already had COVID-19, a new study suggests.
No Advantage Seen With Low-Titer Group O Whole Blood Over Component Therapy in Emergency Transfusion
Researchers sought to determine whether use of low-titer group O whole blood in emergency transfusion would have a survival advantage over component therapy.
Leniolisib Improves Immune Dysfunction in Activated PI3Kδ Syndrome
Researchers sought to determine whether leniolisib would improve markers of immune dysfunction among patients with an inborn error of immunity caused by APDS.
Study Reveals “Suboptimal” MIPS Participation Among Oncologists
Oncologist participation in the merit-based incentive payment system (MIPS) is below national participation across all specialties.
Aspirin and Metformin Combo Linked to Higher Risk of Cancer Death
Among older patients with diabetes, metformin was associated with a reduced risk of cancer, but the combination of aspirin and metformin was associated with an increased risk of cancer death.
Editorial Board Members for Oncology Journals May Sit on Multiple Boards
Editorial board members for oncology-focused journals may sit on multiple editorial boards at the same time.
Healthcare Utilization, Health Status Associated With Neighborhood Disadvantage in Survivors of Blood/Marrow Transplant
Researchers sought to determine whether there was a link between neighborhood disadvantages and health status in survivors of blood or marrow transplants.
COVID-19 Sequelae in Cancer by Vaccination Status and Variant Era
COVID-19 vaccination may reduce the risk of COVID-19 sequelae in patients with cancer, according to researchers.
ASCO Grants Often Awarded to Same Institutions
More than one-third of ASCO grants were awarded to researchers at 4 institutions.
A Dedicated Clinic Decreases Time From Febrile Neutropenia Onset to Treatment
This report describes the results achieved with an outpatient care clinic designed to address febile neutropenia in patients with hematologic cancers.
Total Marrow Irradiation With Fludarabine-Melphalan Is a Feasible Conditioning Regimen for Second Allo-SCT
Researchers sought to determine whether IM-TMI combined with fludarabine and melphalan would be a feasible conditioning regimen for patients undergoing allo-SCT.
Cancer Patients May Fall Prey to Illegitimate Online Pharmacies
High drug prices and ongoing shortages may prompt cancer patients to buy treatments online and fall prey to illegitimate pharmacies.
Delirium Tied to Increased Risk of Death in Critically Ill With Cancer
Critically ill patients with cancer who develop delirium have a higher risk of dying in the hospital or intensive care unit, a study suggests.
Orca-T Improves Allo-HSCT Outcomes Compared With Historical Control
Researchers sought to determine whether Orca-T could improve relapse and survival outcomes compared with historical controls for patients receiving allo-HSCT.
Gaps in Understanding of Palliative Care Hinders Its Use Among Nurse Practitioners
Researchers investigated potential gaps in understanding of palliative care among nurse practitioners in oncology at a large US-based cancer center.
COVID-19 Pandemic-Era Financial Burden High in Survivors of Blood and Marrow Transplantation
Researchers sought to determine the medical costs for survivors of blood or marrow transplantation during a period of the COVID-19 pandemic.
Oncologists Report Negative Impact of Releasing Clinical Info to Patients Immediately
Most oncology providers surveyed said that immediately releasing clinical information to patients has had a negative impact on their practice and patients.
Clonal Hematopoiesis More Prevalent in Pediatric Cancer Survivors
Survivors of pediatric cancer have a higher rate of clonal hematopoiesis than their peers at any age, a study suggests.
Algorithm May Predict ED Visits, Hospitalizations in Cancer Patients
A new algorithm can help predict which cancer patients have a higher risk of visiting the emergency department or requiring hospitalization, according to researchers.
Cancer Patients Reported Symptoms of PTSD During First Year of COVID-19 Pandemic
Patients with cancer experienced symptoms of PTSD during the first year of the COVID-19 pandemic, a French study suggests.
Global Cost of Cancers Projected to Exceed $25 Trillion
From 2020 to 2050, the global economic cost of cancers is projected to be $25.2 trillion in international dollars.
Calcineurin Inhibitor-Free Prophylaxis Associated With Shorter Time to Immunosuppression Withdrawal, GVHD
Researchers assessed whether PTCy with sirolimus would reduce median time to immunosuppression withdrawal and a lower rate of chronic GVHD following allo-HCT.
Azithromycin May Promote Cancer Relapse After Allogeneic Stem Cell Transplantation
Researchers evaluated immune and metabolic function from samples of patients in the ALLOZITHRO trial to determine how azithromycin increases relapse risk after ASCT.
Improving End-of-Life Discussions With Cancer Patients
Timely discussions about end-of-life preferences can ensure patients with advanced cancer receive care that aligns with their goals, experts say.
Distinct Type of Myeloid Neoplasms Characterized by Germline DDX41 Mutations
Researchers conducted a retrospective study to comprehensively characterize DDX41 mutations in a multinational cohort of patients with MNs.
Allogeneic Transplant Reduces Morbidity in Patients With Inborn Errors of Immunity
Researchers sought to determine rates of progressive morbidity in patients with IEI who underwent alloSCT.
Biopsychosocial Screening Program Provides Benefits for Cancer Patients
A biopsychosocial screening program can provide clinical benefits for patients with cancer, a study suggests.
Stimufend, a Biosimilar to Neulasta, Now Available
Stimufend is a leukocyte growth factor.
Prevalence of VEXAS Syndrome Identified in U.S. Health System
Disease-causing UBA1 variants identified in one in 4,269 men older than 50 years and one in 26,238 women older than 50 years.
Itacitinib Is an Effective Treatment for Acute GVHD
Researchers sought to determine whether itacitinib would be an effective treatment for acute GVHD through a multicenter, phase 2 trial.
Bivalent COVID-19 Vaccine May Not Protect Cancer Patients From Current Variants
Pfizer-BioNTech’s bivalent COVID-19 vaccine may not protect cancer patients from the most common omicron subvariant in circulation now, a study suggests.
Immunopeptidome Divergence in Unmatched Donor HCTs May Predict Outcomes
Researchers sought to determine whether immunopeptidome divergence would impact survival in patients undergoing hematopoietic cell transplant.
Black and Hispanic Patients Were More Likely to Delay Cancer Pharmacotherapy During the COVID-19 Pandemic
Researchers sought to determine whether there were delays in or discontinuation of treatment for cancer among different populations during the COVID-19 pandemic.
Momelotinib Found Superior to Danazol for the Treatment of Myelofibrosis
Researchers sought to determine if momelotinib provided better improvements in anemia in patients with myelofibrosis, compared with treatment with danazol.
Aspirin Noninferior to LMWH for Death and Pulmonary Embolism After Traumatic Fracture
Researchers determined aspirin was noninferior to LMWH for rates of mortality and pulmonary embolism in patients with a limb fracture requiring surgery or a pelvic or acetabular fracture.
Female Representation on ASCO Panels Is Increasing, but All-Male Panels Persist
Though female representation on ASCO panels is increasing, women remain underrepresented on certain panels, and all-male panels still exist.
Vaccines Do Not Reduce the Risk of Severe COVID-19 Among Cancer Patients Receiving Certain Therapies
COVID-19 vaccines did not reduce the risk of severe COVID-19 among cancer patients who received radiation, CAR T-cell therapy, or HSCT.
Researchers Call for More Scrutiny of Oncology Trial Reports Written by Medical Writers
Oncology trial reports written by medical writers are more likely to have surrogate endpoints as the primary endpoint.
COG Guidelines Improve Parental Discharge Education for Children With Newly Diagnosed Cancer
A study evaluated implementation of Children’s Oncology Group recommendations for education delivery to parents of children with newly diagnosed cancer.
FDA Releases Draft Guidance With Updated Recommendations for Blood Donation Deferrals for At-Risk Groups
The FDA’s Center for Biologics Evaluation and Research released draft guidance on evaluating donor eligibility by risk-based questions to reduce the risk of HIV transmission by blood and blood products.
AYAs With Hematologic Malignancies Have Higher Risk of Early Death
The risk of early death in AYAs with cancer depends on the type of malignancy they have as well as multiple demographic factors, a study suggests.
AI Can Screen Cancer Patients for Trial Enrollment More Efficiently
Using artificial intelligence to screen cancer patients for clinical trials is effective and efficient, research suggests.
Many Cancer Patients Are Not Screened for Transportation Insecurity, Survey Suggests
Most NCCN member institutions support patients’ transportation needs, but there is a lack of routine screening for transportation insecurity, a survey suggests.
Aggregating Data Hides Cancer Disparities Affecting Asian and NHPI Patients in the US
Aggregated data can hide disparities in cancer incidence and outcomes among Asian and Native Hawaiian/Pacific Islander patients in the US.
Creative Arts Therapy May Help Children with Cancer Cope with Procedural Anxiety
A retrospective secondary analysis sought to determine the effects of creative arts interventions on pediatric patients’ anxiety during the first year of treatment.
Ibrutinib Failed to Improve Outcomes in Previously Untreated Chronic GVHD
Researchers sought to determine whether ibrutinib could improve outcomes in the frontline setting of cGVHD.
Cancer Patients Are Receiving Emergency Care for Potentially Preventable Conditions
Many cancer patients are seeking emergency care for conditions that could be prevented, a study suggests.
Childhood, Adolescent Cancers Linked to Higher Risk of Major Psychiatric Disorders
Compared with the general population, survivors of childhood and adolescent cancers have an increased risk of 6 major psychiatric disorders.
Geography and Race/Ethnicity Impact Access to Pediatric Cancer Care
New research has revealed disparities in access to cancer care among children, adolescents, and young adults in the United States.
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