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General Hematology
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Hematologic Abnormalities Common Among Patients With Pediatric Systemic Lupus Erythematosus
In a multicenter study, researchers evaluated the characteristics of hematologic involvement and assessed the association in patients with pediatric systemic lupus erythematosus.
Patient Response to Vaccination Is Low During and After Anti-CD20 Therapy
Researchers sought to determine the vaccine responsiveness in patients who had received anti-CD20 therapy than in healthy or disease-control populations.
Cognitive Decline May Be Slower With Blood-Brain Barrier Crossing Antihypertensive Drugs
Researchers assessed the ability of antihypertensive drugs to cross the blood-brain barrier.
Cryopreservation of Unrelated Donor SCTs Safe, Effective in Patients Who Underwent HSCT
Researchers sought to determine whether cryopreservation of unrelated donor hematopoietic stem cells would affect outcomes in patients who underwent HSCT since the COVID-19 pandemic.
Risk Factors Identified for All-Cause Mortality in Cancer Patients With COVID-19
Researchers assessed the risk for all-cause mortality in cancer patients with COVID-19.
More Diversity in Medicine, More Equity in Health Care Urgently Needed
The field of medicine has been plagued by the underrepresentation of African Americans, people of Hispanic heritage, and Native Americans, as well as institutional racism and sexism that have persisted for decades.
Tips on Managing Pediatric Anxiety in Primary Care
NP expert discusses screening and treatments for anxiety in children and adolescents in the primary care setting.
Plasma Selenium Predictive of Thyroid Dysfunction in Postpartum Women
Researchers investigated thyroid function in women 6 months postpartum relative to maternal iodine, selenium, and iron status.
Vaccine Expert Discusses EUA of COVID-19 Vaccine for Adolescents
The expanded EUA of the COVID-19 vaccine “will be the biggest positive change for adolescents since the beginning of the lockdown in March 2020.” — Mary Koslap-Petraco, DNP, PPCNP-BC, CPNP, FAANP
Organ Transplant and Poor Antibody Response to SARS-CoV-2 mRNA Vaccine
Johns Hopkins investigators sought to evaluate antibody responses to a second SARS-CoV-2 mRNA vaccine dose among organ transplant recipients.
Heparin and COVID-19: Case Studies Suggest Small Risk of Hematoma
Researchers sought to determine whether there was a risk of developing IPH in patients with COVID-19 treated with heparin.
Fully Vaccinated Travelers Can Soon Visit EU Countries
New measures for tourists and other travelers could take effect as early as next week.
NPs Role in Successful Cancer Survivorship Care
NP expert discusses the 5 principal components of survivorship care for patients with cancer.
Underdosing in Patients With Cancer and Obesity: A Thing of the Past?
New guidelines recommend using the full approved doses of immunotherapy and targeted therapies for patients with cancer and obesity.
Belumosudil Yields Clinically Meaningful Outcomes in Patients With Chronic Graft-Vs-Host Disease
Researchers sough to determine whether belumosudil would help treat patients with chronic GVHD.
Impact of Clostridioides difficile Infections in Hospitalized Pediatric Oncology Patients
A team of investigators sought to assess the impact of Clostridioides difficile infection on outcomes in pediatric patients with cancer.
The Power of Touch: How Physical Contact Can Reshape the Clinical Exam ─ Part II
We continue discussing the power of touch and how has it played into the history of clinical treatment as well as our current reality.
Higher Emotional Intelligence Tied to Higher Job Performance During COVID-19
Previous research has demonstrated relationships between stress, work performance, and emotional intelligence. The researchers in the current study sought to test that relationship in the context of the pandemic.
Expanding Medicaid Eligibility May Improve Survival in Patients With Cancer
Patients living in states with lower eligibility limits had worse survival rates, regardless of cancer stage at diagnosis.
The Power of Touch: How Physical Contact Can Reshape the Clinical Exam — Part 1
What is the power of touch and how has it played into the history of clinical treatment as well as our current reality?
Life After Medicine: Doctors on How They’ve Tackled Retirement
We speak to two doctors about life after hanging up their white coats.
ACP Releases Practice Advice for Short-Course Antibiotics in Common Infections
The American College of Physicians convened a panel to identify best practices for the use of short-course antibiotics in the management of common infections.
Four Factors That Promote Shared Understanding Between Nurses and Physicians in Oncology Care Units
An analysis of 33 video-recorded conversations helped to identify factors that lead to effective communication in oncology care settings.
Anti-T Cell Lymphocyte Globulin Shows Similar Long-Term Outcomes to Post-Transplant Cyclophosphamide for GVHD Prophylaxis
Researchers sought to determine if GVHD prophylaxis with ATLG would be the same as PTCy in terms of long-term outcomes.
FDA OKs Emergency Use of Monoclonal Antibody Sotrovimab for COVID-19
The EUA was granted based on an interim analysis from the phase 1/2/3 COMET-ICE trial, which evaluated sotrovimab in 583 non-hospitalized adults with mild to moderate COVID-19 at high risk of progression to severe disease.
BAFF May Be Promising Therapeutic Target in Graft-Vs-Host Disease
Researchers sought to determine whether targeting BAFF and BCR pathways may improve outcomes in patients with chronic GVHD risk.
Effect of Blood Eosinophil Counts on COPD Clinical Outcomes
Patients with COPD who exhibit low blood eosinophil counts had no change in exacerbations or survival compared with patients with typical counts.
Pfizer-BioNTech COVID-19 Vaccine: Updated Storage Conditions
The FDA has authorized undiluted, thawed vials of the Pfizer-BioNTech COVID-19 Vaccine to be stored in the refrigerator at 2°C to 8°C (35°F to 46°F) for up to 1 month.
Synthetic Sepiapterin Gets Orphan Drug Status for Hyperphenylalaninemia
PTC923 is an oral formulation of synthetic sepiapterin, a precursor to intracellular tetrahydrobiopterin.
HIPAA Needs to Keep Up With Information Technology
Core provisions of the HIPAA legislation have largely remained unchanged since their inception despite rapid evolution of technology to keep protected health information from hackers.
Low-Dose Anti-Thymoglobulin May Help Prophylaxis for Graft Vs Host Disease
Researchers sought to determine whether adding ATG would help improve prophylaxis for GVHD in patients with lymphoid malignancies.
Bempedoic Acid Decreases Lipid Levels Among Patients With Hyperlipidemia
In a review and meta-analysis, investigators evaluated the novel fatty acid inhibitor bempedoic acid as a possible treatment for hyperlipidemia.
Knowledge of Human Leukocyte Antigen Loss After Haploidentical Transplantation Helps Manage Patients With Hematologic Malignancies
Researchers sought to determine whether detecting HLA loss would be helpful in managing patients with hematologic malignancies who relapsed after haploidentical transplantation.
Most US Youth Willing to Get Vaccinated for COVID-19
The purpose of this study was to understand the potential barriers and facilitators to COVID-19 vaccination among youth.
Health Literacy, Demographics Affect Likelihood of Parental Consent to Child Participation in Clinical Trials
Researchers assessed the characteristics that most influence parents’ decision regarding allowing their child to participate in a clinical trial.
FDA: Consumer Electronics May Impact Implanted Medical Devices
The FDA is advising patients with implanted medical devices to consider keeping consumer electronics at least 6 inches away from the implanted medical device.
Strategies for Managing Uncertainty in Patient Care
For many health care professionals, successfully managing uncertainty means recognizing that surety is complicated and illusory and knowledge is iterative and provisional rather than definitive.
Pegcetacoplan Superior to Eculizumab for Patients With Paroxysmal Nocturnal Hemoglobinuria
Researchers sought to determine whether pegcetacoplan would be superior to eculizumab in treatment of low hemoglobin in patients with paroxysmal nocturnal hemoglobinuria
ACIP Recommends Pfizer-BioNTech COVID-19 Vaccine for Adolescents
The recommendation follows the Food and Drug Administration’s authorization for this patient population earlier this week.
Phase 3 Trial Aims To Evaluate Safety, Efficacy of Parsaclisib in Myelofibrosis
Researchers are conducting a phase 3 trial to investigate the safety and efficacy of parsaclisib and ruxolitinib vs placebo and ruxolitinib among patients with myelofibrosis who have displayed a suboptimal response to ruxolitinib only.
The Potential of Nurse Practitioners as Prescribers in Cancer Treatment
This discussion focused on the role of advanced nurse practitioner as cancer therapy prescribers.
FDA Expands Pfizer-BioNTech COVID-19 Vaccine EUA to Include Adolescents
The safety of the vaccine in this patient population was based on data from 2260 adolescent participants.
Risk Factors for Graft Rejection and Pediatric Hematopoietic Stem Cell Transplantation
Researchers sought to determine risk factors for graft rejection in pediatric patients receiving hematopoietic stem cell transplantation for bone marrow failure.
New DOAC Users Experience Fewer Risks for Ischemic Stroke, Major Bleeding vs New Warfarin Users
Study authors assessed the effectiveness and safety of DOACs compared with warfarin in patients with valvular atrial fibrillation.
Strategies for Minimizing Vaccination Pain in Children
Insufficient pain management during childhood immunizations may lead to increased fear of needles and later health care avoidance.
Bacterial Pneumonias, Bloodstream Infections in Hospitalized Patients With COVID-19
Clinicians should adhere to standard best practices for preventing and empirically treating secondary infections in patients hospitalized with COVID-19.
Rare Adverse Thrombotic Events After ChAdOx1 nCov-19 Vaccination
To better understand the development of a rare clotting, investigators conducted a PF4-heparin ELISA and a PF4 ELISA to identify platelet-activating antibodies.
Next Generation Sequencing May Expand Targeted Therapies for Vascular Anomalies
Researchers sought to determine whether next generation sequencing may be a helpful tool to detect actionable variants to provide targeted therapies for patients with vascular anomalies.
Globalization of Cancer Clinical Trials Widens Disparity in Black Patient Enrollment
The median disparity score was 0.19, with a score of 1 indicating no disparity between clinical trial enrollment and burden of disease.
Cancer Screening Plunged Sharply Early in the COVID-19 Pandemic
Investigators found the biggest declines in prostate, breast, and colorectal cancer screening rates among individuals in the Northeast US and those of higher socioeconomic status.
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