Review: COVID-19 Vasculitis or Novel Vasculitis Mimic?
In this interview, Richard Becker, MD, gives us an insight into COVID-19 vasculitis and its manifestations.
General Hematology
GENERAL HEMATOLOGY
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Prophylactic Anticoagulation Reduces Risk of 30-Day Mortality in COVID-19
Did patients with COVID-19 who were admitted to the hospital have a lower risk of 30-day mortality with early use of prophylactic anticoagulation?
Stem Cell Transplantation Increases Mortality Risk From COVID-19, Study Confirms
Patients who have undergone either autologous or allogeneic hematopoietic stem cell transplantation (HSCT) are at high risk for mortality in the event of a COVID-19 diagnosis.
Blood Types O and Rh-Negative Protective Against COVID-19
Investigators determined whether ABO and Rh blood groups were associated with risk for SARS-CoV-2 infection and severe COVID-19 illness.
COVID-19 Convalescent Plasma Shows Early Survival Benefit
Researchers assessed the efficacy of the COVID-19 convalescent plasma in offering survival benefit at 7 and 14 days for patients hospitalized with the disease.
Potential Impact of the COVID-19 Pandemic on Cancer Clinical Trial Participation
ACS Cancer Action Network’s Survivor Views panel reveals willingness and concerns of survivors and patients regarding cancer clinical trial participation during the pandemic.
Cultural Humility: A Way to Reduce Health Disparities in the BIPOC Community
This approach to communication is explained, along with strategies for practicing the approach when treating patients from these communities.
Prolonged Prothrombin Time Signals Disturbed Host Response in Sepsis
A team of investigators sought to assess the association between consumptive coagulopathy, as reflected by a prolonged prothrombin time, and host response aberrations in patients admitted to the intensive care unit with sepsis.
Polycythemia Vera: A Comprehensive Approach to Management
Review highlights current approaches to risk stratification, differential diagnosis, and the optimal use of current treatment options for polycythemia vera.
Study Confirms Stem Cell Transplantation Increases Mortality Risk From COVID-19
Patients who have undergone either autologous or allogeneic hematopoietic stem cell transplantation (HSCT) are at high risk for mortality in the event of a COVID-19 diagnosis.
Strategies for Patient Comfort, Position Holding, and Compliance During Radiotherapy Treatments
A systematic review of studies focused on strategies to improve patient comfort and compliance with radiotherapy treatment plans, finding that aromatherapy strategies show promise in this setting.
Female Doctors Are Especially Vulnerable to Online Harassment
Female physicians are twice as likely as male doctors to be sexually harassed on the internet and are often subject to personal attacks.
Implications of the von Willebrand Factor-ADAMTS13 Axis With COVID-19
A letter to the editor drew attention to the increased risk of thrombotic disorder for patients with severe COVID-19, which seems to occur by interacting with the von Willebrand Factor-ADAMTS13 axis.
5 Ways to Make Patients Feel More Comfortable in Office During Covid
As the COVID-19 pandemic continues, its toll has extended beyond physical and into the emotional realm. A recent study in JAMA Network Open suggested that the prevalence of depression symptoms in the United States was more than 3 times as great during the presence of COVID-19 as it was prior to the pandemic.¹ Americans are…
5 Ways to Help Spanish-Speaking Parents at Your Healthcare Center
Patients who speak Spanish primarily or exclusively have a unique set of struggles and barriers when getting medical care, whether as a patient or caregiver. A language barrier can be stressful and burdensome for parents trying to get help for their child. What can be done about this? A recent study from Academic Pediatrics examined…
Abatacept May Help Prevent Severe Acute Graft-vs-Host Disease
A team of investigators sought to determine the ability of abatacept to decrease the risk of severe acute graft-vs-host disease in patients undergoing unrelated donor allogeneic hematopoietic cell transplant.
American Cancer Society 2021 Statistics Report Shows Continuous Decline in Cancer Mortality Rate, Illuminates Disease-Specific Trends
The American Cancer Society’s annual report approximates the new cancer diagnoses and deaths expected in 2021 and identifies impactful patterns in oncology care.
FDA Updates EUA for COVID-19 Convalescent Plasma
The revision is based on new clinical trial data that showed no evidence of low titer convalescent plasma being effective in the treatment of hospitalized COVID-19 patients.
Acceptance of Industry Payments Declined Among Medical Oncologists After Inception of Open Payments Program
This study sought to identify trends in industry payments to medical oncologists between 2014 and 2019 to determine if the Open Payments program, which has published data on industry-physician financial interactions since 2013, was associated with changes in the frequency or value of payments.
Mortality Following Cancer Surgery Higher in Low-income Countries
A multicenter, prospective cohort study was conducted to compare mortality and complication rates associated with cancer surgery between low-income, middle-income, and high-income countries.
Intermediate-Dose Anticoagulation Associated with Lower In-Hospital COVID-19 Death
A team of investigators sought to determine the effect of intermediate-dose anticoagulation and aspirin on mortality in patients hospitalized with COVID-19.
Anticoagulation Continuation During TAVR: Assessing Bleeding, Complication Risks
The continuation of oral anticoagulation during TAVR did not increase bleeding or vascular complication rates.
New Analysis Does Not Support Eltrombopag With Immunosuppression in Severe Pediatric Aplastic Anemia
New data are reported from an ongoing, prospective, nonrandomized phase 1/2 study of eltrombopag added to immunosuppressive therapy for patients with treatment-naive severe aplastic anemia.
Comprehensive Assessment Aids Treatment Decision-Making in Older Adults With Hematologic Malignancies
A team of investigators conducted a cross-sectional analysis to assess the effect of a geriatric assessment tool on older patients with hematologic malignancies.
Addition of Elotuzumab to RVd Does Not Improve Outcomes in High-Risk Multiple Myeloma
Investigators compared elotuzumab plus lenalidomide, bortezomib, and dexamethasone (RVd) with RVd alone in the induction and maintenance therapy settings.
Controversy: Protecting People Who Use Drugs During COVID-19
Anna Lembke, MD, discusses how patients who use drugs are affected by the convergence of 2 public health emergencies – increasing overdose rates, and the COVID-19 pandemic – and addresses controversial solutions proposed by other investigators.
Proposed HIPAA Changes Promise to Improve Health Care Delivery
The Office for Civil Rights in the US Department of Health and Human Services announced proposed changes to strengthen patients’ rights to access their own health information, improve care coordination, and reduce regulatory burdens.
No Association Between Coronary Heart Disease, Myocardial Infarction and Sickle Cell Trait in African Americans
Investigators aimed to determine whether the sickle cell trait was associated with myocardial infarction or coronary heart disease among African American individuals.
NCCN Guidelines for Multiple Myeloma Updated to Include Three Selinexor Regimens
The National Comprehensive Cancer Network’s updated Clinical Practice Guidelines in Oncology for multiple myeloma newly include 3 new selinexor-containing regimens.
Platelet, Neutrophil Activation Linked to Venous Thromboembolism Risk in COVID-19 Patients
Researchers analyze platelet and neutrophil activation in COVID-19 patients and its association with venous thromboembolism.
Novel Therapy for Heparin Induced Thrombocytopenia Gets Orphan Drug Status
VLX-1005 is a first-in-class and selective small molecule inhibitor of 12-lipoxygenase, a key target within the arachidonic acid pathway.
Do Calcium Channel Blockers Help Reduce Iron Overload in β-Thalassemia?
A team of investigators conducted a systematic literature review and meta-analysis to determine the effectiveness of combined calcium channel blocker and chelation therapy for reducing iron overload in patients with thalassemia.
Potential Med Errors Prompt FDA Action on Vinca Alkaloid Labeling
Chemotherapy agents such as vincristine sulfate injection, vinblastine sulfate injection, and vinorelbine tartrate injection should only be prepared in IV infusion bags.
Low Iron Storage and Arrhythmogenic Susceptibility in Healthy Women of Childbearing Age
Low iron storage may increase arrhythmogenic susceptibility in healthy women of childbearing age.
First Treatment for Newly Diagnosed Light Chain Amyloidosis Approved
The approval was based on data from the open-label, active-controlled phase 3 ANDROMEDA study.
FDA: Update on Blood Donation During COVID-19 Pandemic
To date, there have been no reported cases of transfusion-transmitted coronavirus, including SARS-CoV-2.
Patients Receiving Radiation for Cancer Satisfied, Confident in Routine Care Through Telemedicine
A survey of patients with cancer treated in radiation clinics of a major New York metropolitan cancer center reported satisfaction with telemedicine care, compared with in-person visits.
FDA: SARS-CoV-2 Mutations May Impact Molecular Tests
The FDA is alerting clinical laboratory staff and health care providers regarding the risk of false negative results with any SARS-CoV-2 test if a mutation occurs in the part of the virus’ genome assessed by that test.
Clinical Management of Malignant Infantile Osteopetrosis
Investigators discussed their clinical approaches to the diagnosis and management of malignant infantile osteopetrosis, as well as the management of long-term posttrasnplant complications.
FDA Urges HCPs to Follow Authorized Dosing Schedules for COVID-19 Vaccines
Additional research from the vaccine manufacturers would be needed to support any changes to the dosing schedule.
Higher Pretransplant Vitamin E Levels Associated With Lower Risk for Acute GVHD
Among patients receiving allogeneic stem cell transplantation, high levels of vitamin E may be linked to less acute graft-vs-host disease.
Improvements Seen in Allogeneic Stem Cell Transplantation-Related Mortality
Experts assessed mortality rates linked to allogeneic stem cell transplantation in the past 40 years using data from the European Society for Blood and Marrow Transplantation registry.
Possible Effects of Social Distancing Must Be Considered in Cancer Research
Social shifts related to the COVID-19 pandemic may be uniquely consequential for health behaviors and decisions integral to effective cancer prevention and control.
Treatment Patterns at End of Life in Pediatric Inpatients With Cancer
Investigators assessed the patterns in medication utilization among pediatric inpatients with cancer in their last week of life.
Moderna Ups Production Estimates of COVID-19 Vaccine 2021
According to the Company, 18 million doses have thus far been supplied to the US government.
Comparing Adolescents’ Understanding of Cancer Prognosis With Health Care Providers, Caregivers
Investigators aimed to understand how well adolescents with cancer understand their prognosis compared with their health care providers and caregivers.
Increased Risk for Hospitalization, Death in Patients With Cancer and COVID-19
Patients with cancer, especially those of the African American population, who have COVID-19 infection are at a greater risk of hospitalization and death.
Address Possible Security Lapses as Your Practice Returns to Normal
To accommodate patients remotely during the COVID-19 pandemic, practices may have expanded personnel access to protected health information and relied on devices that might be vulnerable to cyber attacks.
Assessment of Hospital Readmissions in Patients Using an Oncology Service
A retrospective review of charts showed a high percentage of readmissions on an oncology service and 2 potential strategies for reducing this rate.
Distinguishing Neutropenia From Pseudoneutropenia Can Preserve Antineoplastic Therapy
Retrospective analysis demonstrates the value in distinguishing between these conditions to salvage chemotherapy and/or targeted therapy dose in patients with cancer.
Direct Oral Anticoagulants as Effective as Vitamin K Antagonists for Thromboembolic Events With Myeloproliferative Neoplasms
The efficacy and safety of direct oral anticoagulants and vitamin K antagonists in the treatment of ATEs/VTEs in patients with MPNs was compared.
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