According to the results of report published in the Medical Journal of the Islamic Republic of Iran, aerobic training, resistance training, and combined training each improved lipid profiles and self-reported quality of life (QoL) in individuals with moderate hemophilia A who were overweight; however, combined training appeared to be the most effective training method.

The comparative study was a randomized, controlled, assessor-blinded trial (Iranian Registry of Clinical Trials registration number: IRCT20180128038541N1) that evaluated the short-term effects of the 3 exercise training methods on QoL, measured by the 36-Item Short Form Health Survey (SF-36), and lipid profile, including total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), in individuals with moderate hemophilia A who were overweight (defined as body mass index [BMI] of 25-30 kg/m2).  Before and 6 weeks after training, waist-to-hip ratio (WHR), waist circumference (WC), QoL, and lipid profiles were measured.

A total of 60 participants, whose age ranged from 35 to 55 years, were randomized to 4 training groups (n=15 each): aerobic training, resistance training, combined training, and control. Training in the intervention groups comprised 45-minutes of exercises 3 days per week for 6 weeks.

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Compared with the control group, all intervention groups showed significantly decreased body weight, BMI, LDL-C, TC, WHR, and WC (all P <.05) and significantly increased HDL-C and SF-36 subscale scores (all P ≤.001).

Although no significant differences were observed among the intervention groups, a comparison of the mean differences from the control group after 6 weeks of training revealed that the decreases in all blood lipid parameters, notably TC, TG, and LDL-C, and increases HDL-L and SF-36 subscale scores were largest in the combined training group relative to the resistance training and aerobic training groups.

“Most importantly, the most significant changes induced in all blood lipid parameters by [combined training],” the authors wrote. “Therefore, [combined training] may be recommended as a possibly effective therapeutic modality to improve QOL and prevent cardiovascular complications in [patients with hemophilia].”


Parhampour B, Dadgoo M, Torkaman G, et al. Effects of short-term aerobic, resistance and combined exercises on the lipid profiles and quality of life in overweight individuals with moderate hemophilia A: a randomized controlled trial. Med J Islam Repub Iran. 2021;35:70. doi:10.47176/mjiri.35.70