Persistent anemia in the first year after critical illness is common among patients who are hospitalized; however, anemia recovery profiles are needed.
A retrospective analysis suggests that for patients with iron deficiency, intravenous ferumoxytol may be safe and effective when used on a single-dose basis.
Vaso-occlusive crises were linked to an increase in opioid prescriptions in patients with sickle cell disease.
Survey finds variation in practice patterns for obtaining MRI/MRA for stroke prevention and monitoring in patients with sickle cell anemia.
Autologous transplantation with gene-corrected hematopoietic stem cells show engraftment and proliferation in nonconditioned patients with Fanconi anemia.
A current meta-analysis of HIF-PHIs showed that these drugs improve the response rate of hemoglobin and decrease hepcidin levels.
Patients receiving chronic extracorporeal photopheresis therapy are at risk of developing iron deficiency anemia.
In a Japanese study, approximately 1 in 8 CKD patients with anemia failed to respond to darbepoetin alfa therapy.
But no change in opioid use observed for those receiving medical marijuana certification.
Investigators characterized ribosome biogenesis dynamics during erythropoiesis to study the role of ribosome biogenesis in normal erythroid development.
Transferrin saturation and ferritin concentrations improved significantly more in the ferric citrate than ferrous sulfate group over 12 weeks.
Low hemoglobin levels in patients with IgAN increase their risk for end-stage kidney disease, according to new research.
Investigators found sex and racial differences in the risk for end-stage kidney disease among patients with CKD anemia.
The American Society of Hematology released their evidence-based 2020 guidelines on the management of acute and chronic pain in sickle cell disease.
Investigators aimed to determine whether vaporized cannabis would reduce symptoms of chronic pain in adult patients with sickle cell disease.
Couples that are at high risk of having offspring with SCD should be offered pre‐implantation genetic diagnosis treatment to prevent disease transmission.
Investigators compared fixed dose and dose escalation administration of hydroxyurea in pediatric patients with sickle cell anemia.
Although the association between thrombocytosis in iron deficiency anemia is understood, researchers studied the risk for thrombotic complications.
Infection with the virus that causes COVID-19, coupled with use of erythropoiesis-stimulating agents may result in additive prothrombotic effects, according to the authors.
Investigators analyzed graft and survival outcomes among patients with SCD who received liver transplants.
In 2 Japanese trials of nondialysis patients, molidustat proved noninferior to darbepoetin alfa, an erythropoiesis-stimulating agent, in correcting and maintaining hemoglobin levels over 36 weeks.
For patients with SCD, anxiety significantly mediates the effect of sleep disturbances on executive functioning more than depression.
Investigators discuss surgical approaches and outcomes of total and partial splenectomy for the treatment of hereditary hemolytic anemia in children.
A report from the Sickle Cell Disease Implementation Consortium assessed patient-reported outcomes and clinical and psychosocial factors in SCD.
ASH published new clinical guidelines on the prevention, diagnosis, and treatment of CNS complications for children and adults with sickle cell disease.
The FDA has granted Priority Review for the Biologics License Application (BLA) for sutimlimab for the treatment of hemolysis in adult patients with cold agglutinin disease, a rare type of autoimmune hemolytic anemia.
Although SCD is often linked to microvasculature occlusion, some sequelae are caused by erythrocyte membrane weakening.
Children with Diamond-Blackfan anemia may benefit from HSCT when a matched sibling donor or matched unrelated donor is not available.
The studies compared the efficacy and safety of vadadustat to darbepoetin alfa in adult patients on dialysis with anemia due to CKD.
What factors influence transplant outcomes in patients with FA with marrow failure that develops into MDS and AL?
Parents of infants and young children with sickle cell disease were satisfied with the patient-centered medical home model experience in the newborn cohort clinic setting.
Although RPI has been a good tool for evaluating of adult bone marrow erythropoietic response to anemia, it is not an adequate indicator in the pediatric population.
Researchers found that individuals with sickle cell disease have lower HIV infection rates, slower progression to AIDS, and lower HIV-associated mortality.
Febrile neutropenia commonly causes morbidity and mortality in children with severe aplastic anemia but little is known about the spectrum of infections.
The Food and Drug Administration (FDA) has granted Orphan Drug designation to FT-4202 (FORMA Therapeutics) for the treatment of sickle cell disease (SCD).
A special commentary article explained that acute kidney injury can be a complication of vaso-occlusive episodes associated with sickle cell disease.
The FDA has approved Reblozyl® (luspatercept–aamt; Bristol-Myers Squibb and Acceleron) for the treatment of anemia in adults with lower-risk myelodysplastic syndromes.
The FDA has approved the New Drug Application for Triferic AVNU®.
Among those with baseline anemia, hemoglobin levels improved with canakinumab versus placebo.
The authors included 6423 patients with SCD in what is believed to be the first study of the incidence of bleeding events in this patient population.
Treatment with androgen deprivation therapy alone is associated with increased risks for anemia compared with radical prostatectomy alone, a study found.
Patients who received hydroxycarbamide therapy scored higher on several measures of neurocognition compared to patients who did not receive hydroxycarbamide.
Using data from a nationwide registry, researchers characterized the clinical profiles of patients with Diamond-Blackfan anemia.
Gender, alcohol consumption, and levels of C-reactive protein and fibrinogen were found to be associated with prevalence of nonanemic absolute iron deficiency.
Patients with sickle cell disease and vitamin D deficiency reported higher rates of emergency room visits and hospital admissions for pain crises.
A panel of researchers developed evidence-based guidelines to support clinical decision making regarding transfusion support for patients with sickle cell disease.
Patients with autoimmune hemolytic anemia who underwent splenectomy experienced increased cumulative incidences of thromboembolism and sepsis.
Younger women had lower thresholds of serum ferritin increase necessary for a red blood cell measurement increase compared with older women and men.
Researchers assessed the safety and efficacy of a pretransplant conditioning regimen in patients with aplastic anemia undergoing allogeneic transplantation.
Of astronauts who went on space missions of short, medium, and long duration, 7%, 10%, and 48%, respectively, were anemic upon return to Earth.
Thrombotic events and sepsis occurred more frequently in patients who underwent splenectomy and were additionally associated with increased mortality risk.