Among those with baseline anemia, hemoglobin levels improved with canakinumab versus placebo.
The authors included 6423 patients with SCD in what is believed to be the first study of the incidence of bleeding events in this patient population.
Treatment with androgen deprivation therapy alone is associated with increased risks for anemia compared with radical prostatectomy alone, a study found.
Patients who received hydroxycarbamide therapy scored higher on several measures of neurocognition compared to patients who did not receive hydroxycarbamide.
Using data from a nationwide registry, researchers characterized the clinical profiles of patients with Diamond-Blackfan anemia.
Gender, alcohol consumption, and levels of C-reactive protein and fibrinogen were found to be associated with prevalence of nonanemic absolute iron deficiency.
Patients with sickle cell disease and vitamin D deficiency reported higher rates of emergency room visits and hospital admissions for pain crises.
A panel of researchers developed evidence-based guidelines to support clinical decision making regarding transfusion support for patients with sickle cell disease.
Patients with autoimmune hemolytic anemia who underwent splenectomy experienced increased cumulative incidences of thromboembolism and sepsis.
Younger women had lower thresholds of serum ferritin increase necessary for a red blood cell measurement increase compared with older women and men.
Researchers assessed the safety and efficacy of a pretransplant conditioning regimen in patients with aplastic anemia undergoing allogeneic transplantation.
Of astronauts who went on space missions of short, medium, and long duration, 7%, 10%, and 48%, respectively, were anemic upon return to Earth.
Thrombotic events and sepsis occurred more frequently in patients who underwent splenectomy and were additionally associated with increased mortality risk.
Patients who underwent moderate-intensity endurance training experienced improvements in capillary density and number of capillaries around a fiber.
A multicenter, randomized, parallel group, double-blind, placebo-controlled trial found that canakinumab may be well tolerated by pediatric patients with sickle cell anemia.
Researchers found that the addition of eltrombopag to standard immunosuppression therapy did not provide therapeutic benefit to pediatric patients with SAA.
Patients younger than 10 years of age experienced an overall survival rate of 91% regardless of whether they received transplant from a sibling or unrelated donor.
Clinicians reported informing only 42% of families about hematopoietic cell transplantation, citing concerns about safety and cost.
The FDA has approved Adakveo (crizanlizumab-tmca; Novartis) to reduce the frequency of vaso-occlusive crisis (VOC) in patients aged ≥16 years with sickle cell disease.
Individuals with sickle cell disease were estimated to earn nearly $700,000 less over their lifetime compared with similar individuals without sickle cell disease.
The FDA has approved Reblozyl (luspatercept–aamt; Celgene and Acceleron) for the treatment of anemia in adult patients with beta thalassemia who require regular red blood cell transfusions.
Postoperative anemia was significantly associated with a composite end point of mortality and major ischemic outcomes within 90 days.
Researchers found similar incidences of late events in patients who were treated with and without granulocyte colony-stimulating factor.
Approximately two-thirds of patients who completed a screening questionnaire reported having at least 1 unmet socioeconomic need.
The FDA has approved Ultomiris (ravulizumab-cwvz; Alexion) for the treatment of atypical hemolytic uremic syndrome (aHUS) to inhibit complement-mediated thrombotic microangiopathy (TMA) in adult and pediatric patients aged 1 month and older.
More than two-thirds of patients receiving horse antithymocyte globulin plus cyclosporine achieved a very good partial response or better.
Children born to mothers diagnosed with iron-deficiency anemia prior to 30 weeks of gestation were more likely to have a neurodevelopmental disorder.
Nearly two-thirds of ischemic strokes occurred in patients who had not properly completed the STOP protocol.
Low and high hemoglobin levels were associated with increased risk for dementia, white matter hyperintensity volume, and structural connectivity.
In a study of chronic kidney disease patients undergoing vascular access surgery for hemodialysis, severe preoperative anemia was associated with worse outcomes.
Depressive symptoms, spirituality, and missed clinic appointments were all found to correlate with hospital admission in sickle cell disease.
Second-line treatment strategies for severe aplastic anemia include stem cell transplant, immunosuppressive therapy, and thrombopoietin mimetics.
The primary end point was time to readiness for discharge, defined as the difference between the readiness-for-discharge date and time and the start date and time of the first infusion of study drug.
Patients with secondary Evans syndrome demonstrated increased mortality compared with all other cohorts.
Study seeks to recruit up to 45 adults with severe sickle cell disease
Patients with chronic anemia demonstrated a decrease in brain white matter volume proportional to anemia severity.
The FDA has approved Accrufer (ferric maltol; Shield Therapeutics) for the treatment of iron deficiency in adults.
In separate studies, roxadustat showed superiority over placebo at increasing hemoglobin in patients with CKD anemia and demonstrated noninferiority to epoetin in treating anemia in dialysis patients.
Isomaltoside with derisomaltose yielded a more pronounced hematologic response but a similar safety profile compared with iron sucrose.
Priority Review shortens the FDA review time from 10 months to 6 months
Patients presenting at emergency departments were nearly 4 times as likely to be admitted to a hospital as patients presenting at a day hospital.
A study of anemic patients on peritoneal dialysis found that roxadustat maintained target hemoglobin levels even in those who received previous treatment with an erythropoiesis stimulating agent.
A recent study of patients with chronic kidney disease showed that each 1-km increase in the elevation where they live was associated with 33% decreased odds of anemia.
Transfusing red blood cells into cardiac surgery patients only when their hemoglobin levels fall to below 7.5 g/dL does not increase acute kidney injury risk.
Young patients with sickle cell disease underwent dosing schedules guided by analysis of pharmacokinetic data using a population pharmacokinetic model.
Voxelotor may be a safe and efficacious treatment for sickle cell disease, especially at a dosage of 1500 mg/d.
Patients who experienced an iron chelation response had lower transfusion burden and substantial decrease in ferritin values.
Patients demonstrated a 5-year overall survival rate of 86%, with all but 2 patients achieving neutrophil engraftment.
Patients with severe sickle cell disease were more than twice as likely to experience recurrent thromboembolism compared with patients with less severe disease.
Decreased lymphocyte counts and serum immunoglobulin levels were seen in patients irrespective of ribosomal protein genotype and steroid treatment.
Researchers assessed the predictive value of various laboratory parameters for iron overload in patients with congenital hemolytic anemias.