Anemia

Higher Doses of Zinc May Be Needed to Prevent Infection in Pediatric Sickle Cell Anemia

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Researchers assessed whether daily zinc supplementation prevents severe or invasive infection among children with sickle cell anemia.

Doctor compassionately listens to female patient

Predictive Factors Identified for Secondary Myeloid Neoplasms in Patients With Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria

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Vicki Moore, PhD

Researchers sought to identify factors that could be associated with secondary myeloid neoplasms in patients with aplastic anemia and PNH.

DMT for Sickle Cell Anemia Started in Childhood May Prevent Myocardial Fibrosis

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Andrea S. Blevins Primeau, PhD, MBA

Researchers sought to determine whether early initiation of DMT in childhood would prevent myocardial fibrosis in patients with sickle cell anemia.

Risk Factors Identified for Secondary Myeloid Neoplasms in Aplastic Anemia, PNH

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Andrea S. Blevins Primeau, PhD, MBA

Researchers sought to determine risk factors for developing secondary myeloid neoplasm in patients with severe aplastic anemia.

Novel Haploidentical Bone Marrow Transplantation Approach Effective in Relapsed/Refractory Severe Aplastic Anemia

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Lauren Dembeck, PhD

Researchers sought to determine whether a novel approach to haploidentical bone marrow transplantation would be effective in patients with aplastic anemia.

Haploidentical Transplant Effective in Relapsed/Refractory Aplastic Anemia

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Andrea S. Blevins Primeau, PhD, MBA

Researchers sought to determine outcomes of transplantation in relapsed/refractory severe anemia with the use of a haploidentical donor.

SCI Does Not Predict Cognitive Dysfunction in Sickle Cell Anemia

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Andrea S. Blevins Primeau, PhD, MBA

Researchers sought to determine whether silent cerebral infarctions were associated with cognitive performance or impairment among patients SCA.

The approval is based on evidence that the vaccine can prevent anogenital infections, with an ongoing trial looking at throat infection prevention in men likely to be critical for continued approval.

Second SARS-CoV-2 Vaccination Improves Antibody Responses in Patients With Aplastic Anemia, Paroxysmal Nocturnal Hemoglobinuria

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Lauren Dembeck, PhD

Researchers sought to determine whether patients with aplastic anemia and PNH would benefit from a second SARS-CoV-2 vaccination.

Canakinumab Misses Primary Endpoint, But Improved Other Parameters in Patients With Sickle Cell Anemia

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Andrea S. Blevins Primeau, PhD, MBA

Researchers sought to determine whether canakinumab would reduce daily sickle cell anemia-related pain in patients with SCA.

Adding Eltrombopag to Standard Immunosuppression Therapy Effective in Severe Aplastic Anemia

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Jonathan Goodman, MPhil

Researchers sought to determine whether adding eltrombopag to standard immunosuppression therapy would be effective for patients with severe aplastic anemia.

pediatrician and parent talk about patient

Adding Eltrombopag to Immunosuppression Does Not Improve Outcomes in Children With Severe Aplastic Anemia

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Vicki Moore, PhD

Researchers sought to determine whether adding eltrombopag to standard immunosuppressive therapy would improve outcomes in children with SAA.

Only factor VIII trough level and prophylactic treatment showed associations with joint health in univariate analysis.

Novel Genes May Be Therapeutic Targets in Patients With Sickle Cell Anemia

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Jonathan Goodman, MPhil

Researchers sought to determine regulatory mechanisms for fetal hemoglobin regulation may offer novel avenues for therapeutic intervention of SCA.

Young Athletes With Exertional Collapse Associated With Sickle Cell Trait

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Vicki Moore, PhD

Researchers sought to describe 3 cases involving young high school athletes with sickle cell trait who died from exertional collapse.

Eltrombopag Plus Immunosuppression May Not Prevent Relapse for Severe Aplastic Anemia

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Vicki Moore, PhD

Researchers sought to determine whether treatment with eltrombopag and immunosuppression would reduce risk of relapse for patients with severe aplastic anemia.

Mutational Analysis of Human Leukocyte Antigen Alleles and Aplastic Anemia

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Vicki Moore, PhD

Researchers sought to find possible relationships between mutations in human leukocyte antigen alleles and clinical features associated with aplastic anemia.

Eltrombopag Augments Immunosuppression in Severe Aplastic Anemia

Improvement seen in the rate, rapidity, strength of hematologic response in previously untreated patients with severe aplastic anemia

Analysis of Pulmonary Function in Children With Sickle Cell Anemia

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Vicki Moore, PhD

Researchers sought to determine the pulmonary function of pediatric patients with sickle cell anemia and whether it was impaired.

A young patient with cancer suffering from anemia.

Germline Diagnostic Findings More Common in Aplastic Anemia

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Patricia Chaney

Researchers sought to better understand germline predisposition to aplastic anemia and how it contributes to proper diagnosis of the disease.

Anemia May Increase Risks of Ischemic Stroke and Poststroke Mortality

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Vicki Moore, PhD

Researchers sought to determine whether patients with anemia had an increased risk of ischemic stroke and poststroke mortality.

Patients with anemia had worse in-hospital outcomes.

Baseline Blood Counts Best Predictor of Response in Severe Aplastic Anemia

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Patricia Chaney

Researchers sought to determine whether blood counts would be good predictors of response to immunosuppressive therapy plus eltrombopag for patients with severe aplastic anemia.

10 Things Your Patients Should Know About Anemia

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Tom Greenhalgh

Though anemia is the most common blood disorder in the US, are patients educated on how it affects the body and how they have to manage it? Here is what they should know about anemia, how it is caused, and who is at risk.

Hemolysis Risk in Patients With Paroxysmal Nocturnal Hemoglobinuria With COVID-19 Vaccination

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Vicki Moore, PhD

Researchers sought to determine whether there was a possible severe reaction following COVID-19 vaccination in patients with paroxysmal nocturnal hemoglobinuria.

LentiGlobin Gene Therapy Shows Positive Results in Patients With Sickle Cell Disease

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Ariela Katz

Researchers sought to determine whether LentiGlobin was safe and effective for treating a subset of patients with sickle cell disease.

Depiction of sickle cells in the bloodstream.

Cell-Free DNA May Be Involved in Disease Pathophysiology in Sickle Cell Disease

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Jonathan Goodman, MPhil

Researchers sought to determine whether cfDNA is not only a marker of, but makes a contribution to, pathophysiology of sickle cell disease.

Haplo-Identical Donors as an Alternative for Patients With Fanconi Anemia

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Patricia Chaney

Researchers sought to determine whether haplo-identical donors could be an alternative option for patients with Fanconi anemia undergoing HSCT.

Ticagrelor Well-Tolerated in Very Young Children With Sickle Cell Disease

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Patricia Chaney

Researchers sought to determine whether ticagrelor would be a safe and effective option for patients younger than 24 months with sickle cell disease.

Haplo-Identical Donors as an Alternative for Patients With Fanconi Anemia

By

Patricia Chaney

Researchers sought to determine whether haplo-identical donors could be an alternative option for patients with Fanconi anemia undergoing HSCT.

BCL11A Gene Therapy Shows Promise in Sickle Cell Disease

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Jonathan Goodman, MPhil

A single-center, open-label pilot study of 6 patients showed that the BCL11A gene is an effective target for HbF induction.

Metabolic Irregularities of Tryptophan and Serotonin Linked to Morbidity in Fanconi Anemia

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Vicki Moore, PhD

A new study explores disruption of tryptophan metabolism, manifesting as dysregulation of serotonin metabolism, in patients with Fanconi anemia.

BCL11A Inhibition to Induce Fetal Hemoglobin Shows Promise in Sickle Cell Disease

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Jonathan Goodman, MPhil

Among patients with sickle cell disease, inhibition of BCL11A via gene knockdown is an effect target to induce fetal hemoglobin.

IV Iron Products: Adverse Events, Associated Costs Compared

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Cassandra Pardini, PharmD

The comparative study aimed to analyze AEs as well as estimate the associated medical costs for 4 IV iron preparations.

Management of patients with sickle cell disease can vary widely.

Effects of Sickle Cell Disease on Daily Life, Symptoms, and Disease Management

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Patricia Chaney

Investigators aimed to understand patient-reported effects of sickle cell disease on health, wellbeing, and disease management.

Iron Deficiency Anemia: Vitamin C Supplementation May Not Be Necessary

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Jonathan Goodman, MPhil

For patients with iron deficiency anemia, oral iron supplementation use alone is comparable to oral supplementation with vitamin C.

Outcomes With Bone Marrow Transplantation for Sickle Cell Disease

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Vicki Moore, PhD

Bone marrow transplantation was associated with a relatively low rate of vaso-occlusive crises in patients with sickle cell disease.

Endari Label Updated With Benefit Statement, Instructions for Use

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Brian Park, PharmD

Endari (L-glutamine; Emmaus Medical) is an amino acid indicated to reduce the acute complications of sickle cell disease in adult and pediatric patients aged 5 years and older.

A patient lays on a scanner table, preparing for a MRI scan.

Neuroimaging Could Be Part of Fanconi Anemia Screening

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Patricia Chaney

Study results suggest that brain imaging may be a beneficial part of screening processes for patients with suspected Fanconi anemia.

VOC Events Increase Opioid Prescribing in Sickle Cell Disease

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Brandon May

Vaso-occlusive crises were linked to an increase in opioid prescriptions in patients with sickle cell disease.

Survey Finds Variation in Practice Patterns for Neuroimaging in Sickle Cell Anemia

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Patricia Chaney

Survey finds variation in practice patterns for obtaining MRI/MRA for stroke prevention and monitoring in patients with sickle cell anemia.

Gene-Corrected Hematopoietic Stem Cells Show Potential for Engraftment in Fanconi Anemia

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Patricia Chaney

Autologous transplantation with gene-corrected hematopoietic stem cells show engraftment and proliferation in nonconditioned patients with Fanconi anemia.

Patients Undergoing Extracorporeal Photopheresis Should Be Monitored for Iron Deficiency Anemia

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Patricia Chaney

Patients receiving chronic extracorporeal photopheresis therapy are at risk of developing iron deficiency anemia.

Diamond-Blackfan anemia is characterized by a failure of the bone marrow to produce red blood cells.

Erythroid Differentiation Regulation Via p53 Activation During Ribosome Biogenesis

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Lauren Dembeck, PhD

Investigators characterized ribosome biogenesis dynamics during erythropoiesis to study the role of ribosome biogenesis in normal erythroid development.

ASH 2020 Guidelines: Management of Acute and Chronic Pain in Sickle Cell Disease

By

Rita Aghjayan

The American Society of Hematology released their evidence-based 2020 guidelines on the management of acute and chronic pain in sickle cell disease.

african american woman vaping and exhaling cloud of smoke

Does Inhaled Cannabis Reduce Pain in Adults With Sickle Cell Disease?

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Lauren Dembeck, PhD

Investigators aimed to determine whether vaporized cannabis would reduce symptoms of chronic pain in adult patients with sickle cell disease.

Pre‐Implantation Genetic Diagnosis Effective for Sickle Cell Disease Transmission Prevention

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Jonathan Goodman, MPhil

Couples that are at high risk of having offspring with SCD should be offered pre‐implantation genetic diagnosis treatment to prevent disease transmission.