The following article features coverage from the 2021 Annual Meeting of the Society of Hematologic Oncology (SOHO). Click here to read more of Hematology Advisor‘s conference coverage.

More than one-quarter of patients who had chimeric antigen receptor (CAR) T-cell therapy for multiple myeloma in 2018 had a neuropsychiatric disorder (NPD), according to study results presented at the Annual Meeting of the Society of Hematologic Oncology (SOHO).

Researchers used data from the National Inpatient Sample (NIS) in the retrospective study of 200 patients aged ≥18 years who received investigational CAR-T therapy for multiple myeloma. They used International Classification of Diseases; Tenth Revision (ICD-10) procedure and diagnostic codes to identify patients with multiple myeloma; CAR-T procedures; and CAR-T acute complication. Regression models were used to assess the association of NPD with clinical variables.

Participants had a median age of 59 years, 65% were male, 71% were White, and 95% were hospitalized at an urban teaching hospital. The prevalence of NPD in the cohort was 27.5%, with anxiety the most frequently occurring disorder, followed by depression and insomnia. Patients with an NPD were more likely to have a Charlson comorbidity index (CCI) score ≥3 (54.5% vs 20.7%, respectively; P =.01), compared with those without an NPD. No differences were observed in the distribution of NPD for race, age, sex, insurance, or previous bone marrow transplantation.

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The study authors found an association between NPD and CCI ≥3 (odds ratio [OR] 4.60; 95% CI, 1.29-16.40) and between NPD and fever (OR 0.16; 95% CI, 0.04-0.70). No significant association was observed between NPD and neurotoxicity, in-hospital mortality, respiratory or renal failure, length of hospital stay, or hospital charges.

“Patients with multiple comorbidities were at higher risk, while patients with fever during CAR-T therapy were likely underdiagnosed with NPD,” the researchers commented.

Read more of Hematology Advisor’s coverage of SOHO 2021 by visiting the conference page.


Lawal O, Lupak O, Udo I, Emole J. Neuropsychiatric disorders in hospitalized patients undergoing chimeric antigen receptor T cell therapy for multiple myeloma. Paper presented at: Annual Meeting of the Society of Hematologic Oncology (SOHO); September 8-11, 2021. Abstract CT-423.