The following article features coverage from the American Society of Clinical Oncology 2020 meeting. Click here to read more of Hematology Advisor’s conference coverage.
Patients who received radiotherapy with immune checkpoint inhibitor (ICI) treatment may be at a greater risk for hematologic toxicity and pneumonitis, though further research is needed to confirm the connection, according to findings presented at the ASCO20 Virtual Scientific Program.
Previous research suggests that, when combined with ICI treatment, radiotherapy may promote T-cell and inflammatory responses, potentially improving the likelihood of an overall response to therapy. However, it is unknown whether radiotherapy exacerbates the risk of adverse events (AEs) among patients receiving ICIs.
A team of researchers evaluated pooled data from 66 prospective ICI trials to determine whether the addition of radiotherapy affected AE risk. All trials had been submitted to the US Food and Drug Administration (FDA) through the end of 2019.
Of 30,809 patients included in the analysis, participants were sorted based on whether they had received radiotherapy (7835 patients) or not (22,974 patients). In the radiotherapy and no radiotherapy groups, the mean ages were 60.5 and 61.5 years, 63.7% and 61.5% of patients were men, and 29.4% and 41.8% of patients had received 0 or 1 prior lines of therapy, respectively. The most common type of cancer in both groups was lung cancer (30.6% in the radiotherapy arm and 44.7% in the no radiotherapy arm).
The overall rate of AEs was similar in both groups; however, after propensity score matching, analyses suggested that all-grade neutropenia (9.7% with radiotherapy vs 5.8% without), thrombocytopenia (8.2% vs 3.7%, respectively), and fatigue (50.5% vs 48%, respectively) may be more common among those who undergo radiotherapy.
Endocrinopathies appeared to be less common with radiotherapy than without (10.7% vs 12%, respectively).
“Analysis to determine comparability of baseline demographic characteristics, comprehensive AE profile, and timing of [radiotherapy] is underway,” the authors wrote.
Anscher MS, Arora S, Weinstock C, et al. Impact of radiotherapy on risk of adverse events in patients receiving immunotherapy: a U.S. Food and Drug Administration pooled analysis. Presented at: ASCO20 Virtual Scientific Program. J Clin Oncol. 2020;38(suppl):abstr 3018.