New Treatment Options Needed for Immune Thrombocytopenia
Current treatment strategies for immune thrombocytopenic purpura are centered on immunomodulation and decreasing platelet destruction
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Depressive Symptoms May Be Associated With Survival in Patients With Hematologic Malignancies
According to a study published in Psycho‐Oncology, patients with newly diagnosed malignant lymphoma or multiple myeloma who reported depressive symptoms prior to the start of chemotherapy had poorer survival compared with patients who were not initially depressed. The prospective analysis was conducted at the Nagoya City University Hospital in Japan. Researchers sought to investigate the…
Prevalence of Gastrointestinal Bleeding in Patients With von Willebrand Disease
Risk for gastrointestinal bleeding in adult patients with von Willebrand disease (VWD) may be 2.5 times higher compared with adults without VWD, according to results from a retrospective study published in Thrombosis Research. The study included an identification of risk factors. Prevalence of gastrointestinal bleeding was determined by analyzing National Inpatient Sample (NIS) records of…
Slow-Release Iron Treatment Appears Safe and Efficacious in Patients With Iron Deficiency Anemia
Isomaltoside with derisomaltose yielded a more pronounced hematologic response but a similar safety profile compared with iron sucrose.
Crizanlizumab Granted Priority Review for Sickle Cell Pain Crises Prevention
Priority Review shortens the FDA review time from 10 months to 6 months
Extended Oral Anticoagulation Therapy for First Unprovoked Deep Vein Thrombosis
Continuing warfarin therapy for 18 months after an initial 6-month course decreased incidence of venous thrombosis and major bleeding.
Inhibitor Development Is Rare After 75 Days of Exposure to Factor VIII in Severe Hemophilia A
In previously untreated patients with severe hemophilia A, nearly all inhibitory antibodies (inhibitors) against factor VIII develop within 75 days of exposure, according to research published in Blood. Researchers followed 1038 previously untreated pediatric patients with severe hemophilia A who received treatment with factor VIII. Median age of the cohort at first exposure was 1.1…
Mode of Progression After Frontline Treatment Predicts Clinical Outcomes in Patients With CLL
Inferior survival for patients with chronic lymphocytic leukemia who progress with lymphadenopathy
Hospital Admission Rates in Children With Sickle Cell Disease Seeking Pain Management
Patients presenting at emergency departments were nearly 4 times as likely to be admitted to a hospital as patients presenting at a day hospital.
HIV-Induced Expression of PD-L1 on Regulatory B Cells May Promote AIDS-Related NHL
HIV-induced regulatory B cells may inhibit T cell function through multiple mechanisms, potentially driving lymphomagenesis.
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