There was a median bleeding score of 21 among patients with Glanzmann thrombasthenia, 9 in Bernard-Soulier syndrome, 10 in dense granule deficiency, 7 in ADP pathway defect, 8 in TxA2 pathway defect, 6 in isolated thrombocytopenia, and 8 in complex abnormalities.
Long-term survivors of childhood cancers with exercise intolerance may have emotional distress, less social role achievement, and worse HRQOL.
There are up to 80 ADCs in clinical development with close to 600 ongoing trials.
The management of CLL, including delays in work-up and treatment, and modifications to clinical trials, have been implemented across Italy in response to the COVID-19 pandemic.
Helsinn and MEI Pharma have discontinued a phase 3 study evaluating pracinostat, in combination with azacitidine, for frontline treatment of older patients with acute myeloid leukemia.
Prospective trials regarding sedentary lifestyles and all cause mortality using measurements more objective than self-reported activity are currently lacking.
At primary analysis, 40% of patients assigned to the venetoclax arm vs 31% of those assigned to placebo were alive.
The association between functional impairment and symptom burden was shown to be predictive of outcomes for older patients with advanced cancer.
Flow cytometry may provide an efficient, sensitive, and specific tool for the differential diagnosis of breast implant–associated ALCL, but a cell block may be able to answer additional questions about the disease.
Physicians should frame treatment options by their “harms and benefits,” not by their “risks and benefits.”
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