GENERAL HEMATOLOGY

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Mixed Evidence on the Role of Vitamin D in Hematopoietic Stem Cell Transplantation

Recent research suggests that vitamin D deficiency may negatively influence outcomes after hematopoietic stem cell transplantation.

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Novel Risk Score for Progression of Rhinovirus Infection in Hematopoietic Cell Transplantation Recipients

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The risk factors of human rhinovirus lower respiratory tract infection following hematopoietic cell transplantation are not well known.

Second Autologous Hematopoietic Cell Transplantation May Be Underutilized in Relapsed Multiple Myeloma

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Researchers emphasized the need for novel condition regimens and a standardized post-transplantation maintenance approach.

Identifying Risk Factors for Cytomegalovirus Antigenemia in Pediatric Patients

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Researchers assessed risk factors for cytomegalovirus antigenemia in pediatric patients.

Levofloxacin Prophylaxis May Help Prevent Infections After Autologous Stem Cell Transplant

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Patients undergoing autologous stem cell transplant are at increased risk for central line-associated bloodstream infections.

Outcomes of Induction Chemotherapy for Acute Myeloid Leukemia With Multilineage Dysplasia

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Results of a study on the influence of induction chemotherapy on transplant outcomes for patients with acute myeloid leukemia.

Empiric Linezolid May Be Ineffective for Vancomycin-Resistant Enterococcus After AlloHCT

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Patients with fever and neutropenia who had undergone allogeneic hematopoietic stem cell transplantation and experienced pre-engraftment bacteremia were assessed.

T-Cell Lymphopenia Is Associated With Platelet Donation Frequency

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Researchers assessed a possible association between plateletpheresis and lymphopenia when 2 platelet donors were found to have low CD4+ T-lymphocyte counts.

Allogeneic Hematopoietic Cell Transplantation for Sickle Cell Disease and Thalassemia

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Allogeneic hematopoietic cell transplantation was tolerated well by pediatric patients with sickle cell disease and transfusion-dependent thalassemia.

Mixed Evidence on the Role of Vitamin D in Hematopoietic Stem Cell Transplantation

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Recent research suggests that vitamin D deficiency may negatively influence outcomes after hematopoietic stem cell transplantation.

Thalidomide-Based Treatment May Be Viable for Patients With Multiple Myeloma

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Bortezomib-based induction therapy is the current standard of care for patients with multiple myeloma, but thalidomide is a promising contender.

Single-Allele Mismatch May Decrease Non-Relapse Mortality in Unrelated Bone Marrow Transplantation

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A single-allele mismatch was associated with decreased risk of non-relapse mortality and overall mortality compared with a single-antigen mismatch.

Cytarabine as a Chemotherapeutic Agent for Autologous Stem Cell Transplantation in Patients With Multiple Myeloma

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Intermediate-dose cytarabine has been demonstrated to have high efficacy as a chemomobilization agent.

Hemochromatosis Penetrance Decreased Over Time in French Cohort

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Though patients tended to be older at diagnosis, the severity of genetic hemochromatosis has decreased over time.

Incidence and Prognostic Value of Cytogenetic Abnormalities in Systemic Mastocytosis

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The prognostic value of karyotype in systemic mastocytosis, especially in the presence of adverse mutations, is unclear.

Peripheral Blood: An Alternative Source of Stem Cells in Thalassemia

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Accessing peripheral blood as a graft source is easier and less invasive than accessing bone marrow.

Intravenous Immunoglobulin Associated With Hemolytic Anemia in Kawasaki Disease

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Kawasaki is a rare hematologic disease that occurs in fewer than 20,000 patients in the United States annually.

Interferon Alfa Combination Therapy for the Treatment of Myeloproliferative Neoplasms

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Though IFN alfa-2 has been shown to be effective in treating MPNs, it is not the therapy of choice outside of Europe.

Ruxolitinib Plus Azacitidine May Benefit Patients With Myelofibrosis

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The combination of the 2 drugs seems to display synergistic effects.

Screening First-Degree Relatives of Multiple Myeloma Patients May Point to New Prevention Strategies

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Screening first-degree relatives of patients with MM may be a viable prevention strategy.

Alternate Dosing of Ruxolitinib May Alleviate Anemia in Myelofibrosis

By James Nam, PharmD

In a phase 2 study, researchers assessed the efficacy of using a dose-escalation approach to lessen the occurrence and severity of anemia in MF treated with ruxolitinib.

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