Managing Atrial Fibrillation in Patients With Beta Thalassemia Major


Patients with beta thalassemia major may be at higher risk for atrial fibrillation, creating a need for attentive clinical management.

Management of Venous Thrombosis in Unusual Sites


The incidence, pathophysiology, provoking factors, and recommended treatments for several types of unusual thrombosis were summarized in a review article.

Andexanet Alfa and the Role of Reversal Agents for Factor Xa Inhibitors


Andexanet alfa is the first anticoagulant reversal agent to receive global US FDA approval for patients with life-threatening or uncontrolled bleeding.

A New Genomic Dataset May be a Significant Step Forward in Combating Acute Myeloid Leukemia


A dataset comprising 672 tumor specimens collected from 562 patients describes both genetic and functional information about the biology of AML.

The Role of Viral Infections and Vaccines in the Pathogenesis of Antiphospholipid Syndrome

By Helen Fosam

Recent evidence links specific bacterial, viral infections, and vaccination to the development of APS, but these associations are not clear-cut.

Eculizumab May Be Safe in Pregnancy, But Data Are Limited


Eculizumab has been used to treat paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome.

Questions Remain Regarding Venous Thromboembolism Recurrence in Older Adults


Venous thromboembolism recurrence risk may not be any higher in older patients than in younger patients.

Interferon Alfa Combination Therapy for the Treatment of Myeloproliferative Neoplasms


Though IFN alfa-2 has been shown to be effective in treating MPNs, it is not the therapy of choice outside of Europe.

More Proactive Approaches May Be Warranted in Older Patients With Sickle Cell Disease


Complications in older patients with sickle cell disease are sometimes misattributed to their disease, possibly delaying appropriate diagnosis and treatment.

Should Infants Be Treated With von Willebrand Factor Concentrate After Complex Cardiac Surgery?


Researchers comment on the implications of treating newborns and infants with von Willebrand factor (VWF) concentrate.

Managing Medical Complications of Beta-Thalassemia in Adults: An Experience-Based Perspective


Mortality in beta-thalassemia has decreased due to medical advances, allowing physicians to observe and manage disease-related complications in adult patients.

Improved Reporting of Cardiovascular Events Needed in Chronic Myeloid Leukemia Clinical Trials


Second- and third-generation tyrosine kinase inhibitors are associated with a variety of cardiovascular events.

Synthetic or Plant-Based Cannabis for Symptom Relief in Patients With Cancer: Do We Have Any Evidence?

By Brooke Worster, MD

In clinical practice, most physicians and nurse practitioners do not feel comfortable enough with their medical knowledge of cannabis to offer it to patients.

Oncology Community Expresses Concern About Medicare Advantage Step-Therapy Policy

By Bryant Furlow

More than 90 medical societies have called on the US government to reverse a policy allowing step therapy under Medicare Advantage.

Fertility Preservation in Hodgkin's Lymphoma Patients That Undergo Targeted Molecular Therapies: An Important Step Forward From the Chemotherapy Era

[Cancer Management and Research] A review of fertility complications induced by chemotherapy and radiotherapy, as well as possible treatment options for HL patients with fertility problems.

Andrographolide Potentiates the Antitumor Effect of Topotecan in Acute Myeloid Leukemia Cells Through an Intrinsic Apoptotic Pathway

By Mohammad Hassan Hodroj, Achraf Jardaly, Sarah Abi Raad, et al.

[Cancer Management and Research] In this study, researchers explored the potential of andrographolide and topotecan, separately and together, in the in vitro treatment of the U937 acute myeloid leukemic cell line.

Management of Relapsed/Refractory Marginal Zone Lymphoma: Focus on Ibrutinib

By Nathan M. Denlinger, Narendranath Epperla, Basem M. William

[Cancer Management and Research] A review of marginal zone lymphomas, a common and varied group of hematologic malignancies, and their treatment, with a focus on the Bruton's tyrosine kinase ibrutinib.

Infections Complicating the Use of Monoclonal Antibodies for Malignancy

By David C. Helfgott, MD

In this review, David C. Helfgott, MD, editorial advisory board member for Infectious Disease Advisor, focuses on infectious complications from the use of monoclonal antibodies for malignancy.

Venetoclax Found Effective in Relapsed/Refractory Chronic Lymphocytic Leukemia

By John Schieszer, MA

A group of Australian researchers report study findings that demonstrate a significant improvement in PFS in patients with relapsed/refractory CLL treated with venetoclax plus rituximab compared with the standard care.

Taste Changes After Hematopoietic Stem Cell Transplant Affect QOL in Blood Cancers

By James Nam, PharmD

Slight changes in taste perceptions are noted in patients undergoing HSCT for hematologic cancers. In this study, researchers sought to determine how these changes affect quality of life and nutritional intake.