Indications for: NARCAN NASAL SPRAY

Reversal of known or suspected opioid overdose, including respiratory and/or CNS depression.

Adults and Children:

Give as single spray intranasally into one nostril. May give additional doses (using a new nasal spray) every 2–3mins in alternate nostrils if unresponsive or relapses into respiratory depression. 

NARCAN NASAL SPRAY Warnings/Precautions:

Not a substitute for emergency medical care. Seek immediate emergency medical assistance after the first dose. Known or suspected opioid dependence; abrupt reversal may precipitate acute withdrawal syndrome. Monitor patients with satisfactory response due to long duration of some narcotics. Post-op use in preexisting cardiac disorders; monitor. Have other resuscitative measures available. Elderly. Pregnancy; monitor for neonatal withdrawal symptoms. Nursing mothers.

NARCAN NASAL SPRAY Classification:

Opioid antagonist.


Caution with cardiotoxic drugs. Incomplete reversal of buprenorphine or pentazocine; may require higher naloxone dose.

Adverse Reactions:

Increased BP, musculoskeletal pain, headache, nasal effects (eg, dryness, edema, congestion, inflammation); opioid withdrawal.


Hepatic (glucuronide conjugation).

Drug Elimination:

Renal. Half-life: 2.08 hours.

Generic Drug Availability:


How Supplied:

Single-dose nasal spray—2