Colorectal disorders:

Indications for: LIALDA

For induction and maintenance of remission in adults with mildly to moderately active ulcerative colitis. To treat mildly to moderately active ulcerative colitis in pediatric patients weighing ≥24kg.

Adult Dosage:

Swallow whole with food. Induction: 2.4–4.8g once daily. Maintenance: 2.4g once daily.

Children Dosage:

<24kg: not established. Swallow whole with food. Take once daily. 24–35kg (Weeks 0 to 8): 2.4g; (after Week 8): 1.2g. >35–50kg (Weeks 0 to 8): 3.6g; (after Week 8): 2.4g. >50kg (Weeks 0 to 8): 4.8g; (after Week 8): 2.4g.

LIALDA Warnings/Precautions:

Sulfasalazine allergy. Upper GI tract obstruction (eg, pyloric stenosis) may delay onset of action. Discontinue if acute intolerance syndrome is suspected. Discontinue at the 1st signs/symptoms of severe cutaneous adverse reactions. Conditions predisposing to myocarditis or pericarditis. Atopic dermatitis or eczema: may have more severe photosensitivity reactions. Nephrolithiasis. Ensure adequate hydration. Renal or hepatic impairment. History of renal disease. Assess renal function prior to and periodically during therapy. Discontinue if renal function deteriorates while on therapy. Elderly (monitor CBCs, platelets). Pregnancy. Nursing mothers: monitor infants.

LIALDA Classification:

Aminosalicylate.

LIALDA Interactions:

Increased toxicity with nephrotoxic drugs (eg, NSAIDs). Increased risk for blood disorders, bone marrow failure, and associated complications with azathioprine or 6-mercaptopurine and/or other drugs known to cause myelotoxicity. May cause elevated test results when measuring urinary normetanephrine.

Adverse Reactions:

Headache, flatulence, abnormal LFTs, abdominal pain, diarrhea; children also: upper RTI, vomiting, anemia, viral infection; acute intolerance syndrome (cramping, bloody diarrhea, fever, headache, rash), renal impairment, hypersensitivity reactions, severe cutaneous adverse reactions (eg, SJS, TEN, DRESS, AGEP); rare: pancreatitis.

Metabolism:

Hepatic.

Drug Elimination:

Renal.

Generic Drug Availability:

YES

How Supplied:

Tabs—120

Pricing for LIALDA

1.2g tablet (Qty: 120)
Appx. price $282
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