Imaging agents:

Indications for: GLEOLAN

As an adjunct for the visualization of malignant tissue during surgery in patients with glioma (suspected WHO Grades III or IV on pre-op imaging).

Adult Dosage:

See full labeling. Administer 20mg/kg orally 3hrs (range 2–4hrs) prior to anesthesia.

Children Dosage:

Not established.

GLEOLAN Contraindications:

Porphyrin hypersensitivity. Acute or chronic porphyria.

GLEOLAN Warnings/Precautions:

Should only be used by trained neurosurgeons. Reduce exposure to sunlight or room lights for 48hrs after administration. Risk of misinterpretation (including false [–] and [+]). Have CPR equipment and personnel available to manage hypersensitivity reactions; monitor. Renal and hepatic impairment. Pregnancy. Nursing mothers: pump and discard breast milk for 24hrs after dose.

GLEOLAN Classification:

Optical imaging agent.

GLEOLAN Interactions:

Risk of phototoxic reactions with phototoxic drugs (eg, St. John’s wort, griseofulvin, thiazide diuretics, sulfonylureas, phenothiazines, sulfonamides, quinolones, tetracyclines, ALA-containing topical preps); avoid for 24hrs before and after Gleolan.

Adverse Reactions:

Pyrexia, hypotension, nausea, vomiting, chills, photosensitivity reaction, solar dermatitis, abnormal LFTs, diarrhea, neurologic events (eg, aphasia, hemiparesis, hemianopia, headache, seizure, hemiplegia, monoparesis, hypoesthesia), brain edema, elevated liver enzymes.

Generic Drug Availability:


How Supplied: