Imaging agents:
Indications for: GLEOLAN
As an adjunct for the visualization of malignant tissue during surgery in patients with glioma (suspected WHO Grades III or IV on pre-op imaging).
Adult Dosage:
See full labeling. Administer 20mg/kg orally 3hrs (range 2–4hrs) prior to anesthesia.
Children Dosage:
Not established.
GLEOLAN Contraindications:
Porphyrin hypersensitivity. Acute or chronic porphyria.
GLEOLAN Warnings/Precautions:
Should only be used by trained neurosurgeons. Reduce exposure to sunlight or room lights for 48hrs after administration. Risk of misinterpretation (including false [–] and [+]). Have CPR equipment and personnel available to manage hypersensitivity reactions; monitor. Renal and hepatic impairment. Pregnancy. Nursing mothers: pump and discard breast milk for 24hrs after dose.
GLEOLAN Classification:
Optical imaging agent.
GLEOLAN Interactions:
Risk of phototoxic reactions with phototoxic drugs (eg, St. John’s wort, griseofulvin, thiazide diuretics, sulfonylureas, phenothiazines, sulfonamides, quinolones, tetracyclines, ALA-containing topical preps); avoid for 24hrs before and after Gleolan.
Adverse Reactions:
Pyrexia, hypotension, nausea, vomiting, chills, photosensitivity reaction, solar dermatitis, abnormal LFTs, diarrhea, neurologic events (eg, aphasia, hemiparesis, hemianopia, headache, seizure, hemiplegia, monoparesis, hypoesthesia), brain edema, elevated liver enzymes.
Generic Drug Availability:
NO
How Supplied:
Pwd—50mL
