Indications for: FORANE
Induction and maintenance of general anesthesia.
Adults and Children:
See full labeling. Individualize. Induction: inspired concentrations of 1.5–3% isoflurane usually produce surgical anesthesia in 7–10 minutes. Maintenance: surgical levels of anesthesia may be sustained with a 1–2.5% concentration when nitrous oxide is used concomitantly. An additional 0.5–1% may be required when isoflurane is given using oxygen alone. If added relaxation is required, supplemental doses of muscle relaxants may be used.
In whom general anesthesia is contraindicated. Hypersensitivity to other halogenated agents. Genetic susceptibility to malignant hyperthermia. History of confirmed hepatitis due to a halogenated inhalational anesthetic or a history of unexplained moderate to severe hepatic dysfunction (eg, jaundice associated with fever and/or eosinophilia) after anesthesia with isoflurane or other halogenated inhalational anesthetics.
To be administered only by those experienced in general anesthesia. Have intubation, artificial ventilation, oxygen and circulatory resuscitation available. Monitor for perioperative hyperkalemia esp. in pediatric patients during post-op period and those with latent or overt neuromuscular disease (eg, Duchenne muscular dystrophy); cardiac arrhythmias and death may occur. Risk of malignant hyperthermia; discontinue all triggering agents if suspected (eg, volatile anesthetic agents, succinylcholine). Underlying hepatic conditions. Pediatric neurotoxicity risk with repeated or prolonged use. Pregnancy. Nursing mothers.
Caution with desiccated CO2 absorbents; replace before administration. Caution with drugs known to cause hepatic dysfunction. Hyperkalemia with succinylcholine. Potentiates effects of muscle relaxants, esp. nondepolarizing muscle relaxants. Marked hypotension with calcium antagonists. MAC reduced by concomitant nitrous oxide, opioids (eg, fentanyl). Concomitant beta blockers may exaggerate cardiovascular effects of inhalational anesthetics. Concomitant MAOIs may increase the risk of hemodynamic instability (during surgery, medical procedures).
Agitation, breath holding, chills/shivering, cough, delirium, laryngospasm, nausea, vomiting; respiratory depression, arrhythmias, elevated liver enzymes, hypotension; hepatic reactions (eg, post-op hepatic dysfunction, hepatitis with/without jaundice, hepatic necrosis or failure), hypersensitivity reactions, QTc prolongation.
Generic Drug Availability:
Bottles (100mL, 250mL)—6