Pituitary disorders:

Indications for: Desmopressin Acetate Spray

Central diabetes insipidus.

Limitations of Use:

Not indicated for nephrogenic diabetes insipidus, primary nocturnal enuresis, patients with conditions that compromise intranasal route of administration, or patients with an impaired level of consciousness.

Adult Dosage:

Individualize. 10–40mcg once daily into 1 nostril (or 40mcg divided into 2–3 daily doses). Use other forms for doses <10mcg or doses other than multiples of 10mcg. If switching from desmopressin acetate injection to nasal spray, use 10 times the amount of desmopressin acetate rounding down to the nearest 10mcg. If switching from desmopressin acetate tablets to nasal spray, individual dose titration is required.

Children Dosage:

<4yrs: not recommended. Individualize. ≥4yrs: initially 10mcg once daily into 1 nostril; may increase to 30mcg once daily (or in 2 divided doses, usually 20mcg in the AM and 10mcg in the PM). Use other forms for doses <10mcg. If switching from desmopressin acetate tablets to nasal spray, individual dose titration is required.

Desmopressin Acetate Spray Contraindications:

Moderate to severe renal impairment (CrCl <50mL/min). Hyponatremia, or history of.

Desmopressin Acetate Spray Warnings/Precautions:

Monitor fluid intake, urine volume and osmolality. Fluid/electrolyte imbalance (eg, cystic fibrosis). Habitual or psychogenic polydipsia. Coronary artery insufficiency. Hypertension. Inj: Predisposition to thrombosis. Nasal mucosal abnormalities (nasal forms). Young children. Elderly. Pregnancy. Nursing mothers.

Desmopressin Acetate Spray Classification:

Vasopressin (synthetic).

Desmopressin Acetate Spray Interactions:

Caution with other pressor agents, drugs that may increase the risk of water intoxication with hyponatremia (eg, tricyclic antidepressants, SSRIs, chlorpromazine, opiates, NSAIDs, lamotrigine, carbamazepine). Possible convulsions with oxybutynin, imipramine.

Adverse Reactions:

Headache, nausea, flushing, abdominal cramps, vulval pain, water intoxication, hyponatremia, nasal congestion or rhinitis (nasal forms), inj site reaction; rare: changes in BP, severe allergic reactions, seizures in children from plasma hypoosmolality, thrombotic events (inj).

Drug Elimination:

Renal. Half-life: 7.8 minutes (initial), 75.5 minutes (terminal).

How Supplied:

Tabs—100; Amp (1mL)—10; Multi-dose vial (10mL)—1; Nasal spray—Contact generic supplier