Musculoskeletal pain:

Indications for: Chlorzoxazone

As adjunct to rest, physical therapy, and other measures in acute, painful musculoskeletal conditions.

Adult Dosage:

250–500mg 3–4 times daily. Painful musculoskeletal conditions: initially 500mg 3–4 times daily. May increase to 750mg 3–4 times daily if inadequate response. May reduce dose based on improvement.

Children Dosage:

Not recommended.

Chlorzoxazone Contraindications:

Known drug intolerance.

Chlorzoxazone Warnings/Precautions:

Monitor for hepatotoxicity; discontinue if hepatic dysfunction or abnormal liver enzymes develop. Known allergies or history of. Discontinue if sensitivity reaction occurs. Pregnancy.

Chlorzoxazone Classification:

Muscle relaxant (central).

Chlorzoxazone Interactions:

Additive effects with concomitant alcohol, other CNS depressants.

Adverse Reactions:

Drowsiness, dizziness, lightheadedness, malaise, overstimulation; rare: skin rash, petechiae, ecchymosis, fatal hepatocellular toxicity.


Formerly known under the brand name Lorzone, Paraflex, Parafon Forte DSC.

How Supplied:

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