Multiple sclerosis:

Indications for: AMPYRA

To improve walking in patients with multiple sclerosis (demonstrated by an increase in walking speed).

Adult Dosage:

Swallow whole. ≥18yrs: max 10mg every 12hrs.

Children Dosage:

<18yrs: not established.

AMPYRA Contraindications:

History of seizures. Moderate or severe renal impairment (CrCl ≤50mL/min). Hypersensitivity to 4-aminopyridine.

AMPYRA Warnings/Precautions:

Assess renal function before initiation; monitor at least annually. Mild renal impairment (CrCl 51–80mL/min): increased risk of seizures. Discontinue if signs/symptoms of anaphylaxis occurs. Pregnancy. Nursing mothers.

AMPYRA Classification:

Potassium channel blocker.

AMPYRA Interactions:

Discontinue other forms of 4-aminopyridine prior to initiating. Concomitant OCT2 inhibitors (eg, cimetidine) may potentiate the risk of seizures.

Adverse Reactions:

UTI, insomnia, dizziness, headache, nausea, asthenia, back pain, balance disorder, MS relapse, paresthesia, nasopharyngitis, constipation, dyspepsia, throat pain; seizures (possible at higher doses), severe allergic reactions.

Generic Drug Availability:


How Supplied:


Pricing for AMPYRA

10mg tablet (Qty: 60)
Appx. price $61