Bacterial infections:
Indications for: Amoxicillin/Clavulanic Acid Ext-Rel
Susceptible infections including community-acquired pneumonia and acute bacterial sinusitis (see full labeling).
Adult Dosage:
Take with meals. May split scored tabs; do not reduce dose. Two amoxicillin/clavulanic acid 500mg tabs are not equivalent to one ext-rel tab. ≥16yrs: 2 tabs every 12 hrs. Sinusitis: treat for 10 days. CAP: treat for 7–10 days.
Children Dosage:
<16yrs: not recommended.
Amoxicillin/Clavulanic Acid Ext-Rel Contraindications:
History of amoxicillin/clavulanic acid-associated cholestatic jaundice/hepatic dysfunction. Ext-rel: Severe renal impairment (CrCl <30mL/min) or hemodialysis.
Amoxicillin/Clavulanic Acid Ext-Rel Warnings/Precautions:
Cephalosporin, imipenem, or other allergy: not recommended. Monitor blood, renal, and hepatic function in long-term use. Monitor closely if skin rash develops; discontinue if lesions progress. Hepatic dysfunction. Mononucleosis. Elderly (consider monitoring renal function). Labor & delivery. Pregnancy (Cat.B). Nursing mothers.
See Also:
Amoxicillin/Clavulanic Acid Ext-Rel Classification:
Broad-spectrum penicillin + β-lactamase inhibitor.
Amoxicillin/Clavulanic Acid Ext-Rel Interactions:
May cause false (+) glucose test with Clinitest, Benedict's or Fehling's soln. Probenecid potentiates amoxicillin. May potentiate oral anticoagulants (monitor). May antagonize oral contraceptives.
Adverse Reactions:
Diarrhea, nausea, abdominal pain, rash, urticaria, vomiting, vaginitis; anaphylaxis, severe cutaneous adverse reactions (eg, SJS, TEN, DRESS, AGEP).
How Supplied:
Ext-rel tabs—contact supplier; Tabs 875mg—20; Susp 125mg/5mL, 250mg/5mL—75mL, 100mL, 150mL; Chew tabs—contact supplier; Susp ES-600 600mg/5mL—50mL, 75mL, 100mL, 125mL, 150mL, 200mL
