Indications for: AKYNZEO INJECTION

Prevention of acute and delayed nausea and vomiting due to initial and repeat courses of highly emetogenic chemotherapy.

Limitations of Use:

Not studied for prevention of nausea and vomiting associated with anthracycline plus cyclophosphamide chemotherapy.

Adult Dosage:

Infuse over 30mins. ≥18yrs: Highly emetogenic chemotherapy (including cisplatin-based): 1 vial approx. 30mins prior to chemotherapy with oral dexamethasone 12mg given 30mins before chemotherapy on Day 1, then 8mg orally once daily on Days 2–4.

Children Dosage:

<18yrs: not established.

AKYNZEO INJECTION Warnings/Precautions:

Monitor for symptoms of serotonin syndrome; discontinue and treat if occurs. Severe hepatic or renal impairment, ESRD: avoid. Elderly. Pregnancy. Nursing mothers.


Substance P/NK1 receptor antagonist + 5-HT3 receptor antagonist.


Increased risk of serotonin syndrome with concomitant other serotonergic drugs (eg, SSRIs, SNRIs, MAOIs, mirtazapine, fentanyl, lithium, tramadol, IV methylene blue). May potentiate CYP3A4 substrates (eg, dexamethasone [use reduced dose], midazolam, alprazolam, triazolam, docetaxel, paclitaxel, etoposide, irinotecan, cyclophosphamide, ifosfamide, imatinib, vinorelbine, vinblastine, vincristine); caution and monitor. Avoid concomitant strong CYP3A4 inducers (eg, rifampin). Potentiated by strong CYP3A4 inhibitors (eg, ketoconazole). Concomitant warfarin: monitor INR and adjust dose as needed. Inj: incompatible with divalent cation-containing solutions, Lactated Ringer's Injection, Hartmann's Solution.

Adverse Reactions:

Headache, asthenia, dyspepsia, fatigue, constipation, erythema; hypersensitivity reactions.

Generic Drug Availability:


How Supplied:

Tabs—1, 4; Single-dose vials (pwd or soln)—1